(21 nodes) Methylosome network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPPAP00000042728	Uncharacterized protein. (325 aa)
	SNRPF	Sm domain-containing protein. (127 aa)
	ERH	Enhancer of rudimentary homolog; May have a role in the cell cycle. (103 aa)
	ENSPPAP00000027407	Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (78 aa)
	ENSPPAP00000007658	Uncharacterized protein. (191 aa)
	SNRPG	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (96 aa)
	WDR77	WD repeat domain 77. (352 aa)
	SNRPD2	Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (118 aa)
	ENSPPAP00000028920	Sm domain-containing protein. (74 aa)
	ENSPPAP00000036002	Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (67 aa)
	ENSPPAP00000029044	Sm domain-containing protein. (78 aa)
	ENSPPAP00000029046	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (70 aa)
	SNRPE	Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (92 aa)
	ENSPPAP00000037569	Uncharacterized protein. (134 aa)
	ENSPPAP00000041319	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (68 aa)
	ENSPPAP00000026938	Enhancer of rudimentary homolog; May have a role in the cell cycle. (112 aa)
	SNRPB	Small nuclear ribonucleoprotein-associated protein. (231 aa)
	CLNS1A	Chloride nucleotide-sensitive channel 1A. (237 aa)
	ENSPPAP00000025338	Uncharacterized protein. (56 aa)
	PRMT1	Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
	PRMT5	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (620 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLNS1A	ENSPPAP00000025338	ENSPPAP00000025628	ENSPPAP00000025338	Chloride nucleotide-sensitive channel 1A.	Uncharacterized protein.	0.542
CLNS1A	ENSPPAP00000027407	ENSPPAP00000025628	ENSPPAP00000027407	Chloride nucleotide-sensitive channel 1A.	Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development.	0.542
CLNS1A	ENSPPAP00000028920	ENSPPAP00000025628	ENSPPAP00000028920	Chloride nucleotide-sensitive channel 1A.	Sm domain-containing protein.	0.523
CLNS1A	ENSPPAP00000029044	ENSPPAP00000025628	ENSPPAP00000029044	Chloride nucleotide-sensitive channel 1A.	Sm domain-containing protein.	0.617
CLNS1A	ENSPPAP00000029046	ENSPPAP00000025628	ENSPPAP00000029046	Chloride nucleotide-sensitive channel 1A.	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.	0.498
CLNS1A	ENSPPAP00000036002	ENSPPAP00000025628	ENSPPAP00000036002	Chloride nucleotide-sensitive channel 1A.	Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development.	0.542
CLNS1A	ENSPPAP00000041319	ENSPPAP00000025628	ENSPPAP00000041319	Chloride nucleotide-sensitive channel 1A.	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.	0.498
CLNS1A	PRMT1	ENSPPAP00000025628	ENSPPAP00000023756	Chloride nucleotide-sensitive channel 1A.	Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.455
CLNS1A	PRMT5	ENSPPAP00000025628	ENSPPAP00000017972	Chloride nucleotide-sensitive channel 1A.	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily.	0.983
CLNS1A	SNRPB	ENSPPAP00000025628	ENSPPAP00000026459	Chloride nucleotide-sensitive channel 1A.	Small nuclear ribonucleoprotein-associated protein.	0.531
CLNS1A	SNRPD2	ENSPPAP00000025628	ENSPPAP00000030062	Chloride nucleotide-sensitive channel 1A.	Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome.	0.838
CLNS1A	SNRPE	ENSPPAP00000025628	ENSPPAP00000036605	Chloride nucleotide-sensitive channel 1A.	Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development.	0.542
CLNS1A	SNRPF	ENSPPAP00000025628	ENSPPAP00000000818	Chloride nucleotide-sensitive channel 1A.	Sm domain-containing protein.	0.700
CLNS1A	SNRPG	ENSPPAP00000025628	ENSPPAP00000012562	Chloride nucleotide-sensitive channel 1A.	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.	0.563
CLNS1A	WDR77	ENSPPAP00000025628	ENSPPAP00000031861	Chloride nucleotide-sensitive channel 1A.	WD repeat domain 77.	0.980
ENSPPAP00000007658	ENSPPAP00000025338	ENSPPAP00000007658	ENSPPAP00000025338	Uncharacterized protein.	Uncharacterized protein.	0.542
ENSPPAP00000007658	ENSPPAP00000027407	ENSPPAP00000007658	ENSPPAP00000027407	Uncharacterized protein.	Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development.	0.542
ENSPPAP00000007658	ENSPPAP00000028920	ENSPPAP00000007658	ENSPPAP00000028920	Uncharacterized protein.	Sm domain-containing protein.	0.523
ENSPPAP00000007658	ENSPPAP00000029044	ENSPPAP00000007658	ENSPPAP00000029044	Uncharacterized protein.	Sm domain-containing protein.	0.617
ENSPPAP00000007658	ENSPPAP00000029046	ENSPPAP00000007658	ENSPPAP00000029046	Uncharacterized protein.	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.	0.498