(76 nodes) Phagocytic vesicle network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RAB9B	RAB9B, member RAS oncogene family. (201 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (472 aa)
	HLA-C	Major histocompatibility complex, class I, C; Belongs to the MHC class I family. (397 aa)
	CALR	Calreticulin. (417 aa)
	INPP5B	Inositol polyphosphate-5-phosphatase B. (997 aa)
	RAB23	RAB23, member RAS oncogene family. (237 aa)
	PLA2G5	Phospholipase A(2). (138 aa)
	VAMP3	V-SNARE coiled-coil homology domain-containing protein. (116 aa)
	LOC100986336	TIR domain-containing protein. (1033 aa)
	CORO6	Coronin; Belongs to the WD repeat coronin family. (472 aa)
	LTF	Lactotransferrin; Belongs to the transferrin family. (711 aa)
	ITGB5	Integrin beta; Belongs to the integrin beta chain family. (803 aa)
	OCRL	OCRL inositol polyphosphate-5-phosphatase. (887 aa)
	MPEG1	Macrophage expressed 1. (716 aa)
	RAB31	RAB31, member RAS oncogene family. (183 aa)
	RAB9A	RAB9A, member RAS oncogene family. (201 aa)
	TLR2	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
	SNAP23	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
	TLR7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
	RAB32	RAB32, member RAS oncogene family. (220 aa)
	PIP4P1	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (284 aa)
	RAB11B	Uncharacterized protein. (221 aa)
	GNLY	Granulysin. (173 aa)
	TCIRG1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
	CTSS	Cathepsin S; Belongs to the peptidase C1 family. (331 aa)
	RAB22A	RAB22A, member RAS oncogene family. (194 aa)
	RAC2	Rac family small GTPase 2. (192 aa)
	PDIA3	Protein disulfide-isomerase. (505 aa)
	HLA-G	Major histocompatibility complex, class I, G; Belongs to the MHC class I family. (355 aa)
	UNC93B1	Unc-93 homolog B1, TLR signaling regulator. (561 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (461 aa)
	RAB14	RAB14, member RAS oncogene family. (212 aa)
	ATP6V0A4	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (782 aa)
	ENSPPAP00000018513	ATPase_AAA_core domain-containing protein. (340 aa)
	ATP6V0E2	ATPase H+ transporting V0 subunit e2. (213 aa)
	VAMP7	Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (260 aa)
	LOC100993063	MACPF domain-containing protein. (701 aa)
	RAB20	RAB20, member RAS oncogene family. (234 aa)
	ANXA3	Annexin. (323 aa)
	ENSPPAP00000021549	Uncharacterized protein. (160 aa)
	HVCN1	Hydrogen voltage gated channel 1. (274 aa)
	ATP6V0A1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (838 aa)
	PIP4P2	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (243 aa)
	LAMP1	Lysosomal associated membrane protein 1. (465 aa)
	SLC11A1	Solute carrier family 11 member 1. (550 aa)
	GABARAPL1	Uncharacterized protein. (117 aa)
	ANXA11	Annexin. (542 aa)
	ATP6V0A2	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
	RAB38	RAB38, member RAS oncogene family. (211 aa)
	ATP6V0E1	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
	RAB34	RAB34, member RAS oncogene family. (268 aa)
	RAB7B	RAB7B, member RAS oncogene family. (199 aa)
	RAB8B	RAB8B, member RAS oncogene family. (207 aa)
	SYK	Tyrosine-protein kinase. (635 aa)
	ZDHHC5	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (715 aa)
	APPL1	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (709 aa)
	NCF2	Neutrophil cytosolic factor 2. (526 aa)
	FMNL1	Formin like 1. (1018 aa)
	ENSPPAP00000031464	Thioredoxin domain-containing protein. (484 aa)
	PIKFYVE	Phosphoinositide kinase, FYVE-type zinc finger containing. (2098 aa)
	SYT11	Synaptotagmin 11. (431 aa)
	MPO	Myeloperoxidase. (745 aa)
	ATP6V0B	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (261 aa)
	RAB11FIP1	RAB11 family interacting protein 1. (1159 aa)
	ABCA1	ATP binding cassette subfamily A member 1. (2264 aa)
	RAB8A	RAB8A, member RAS oncogene family. (207 aa)
	CLEC4E	C-type lectin domain-containing protein. (174 aa)
	ATP6V0C	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (647 aa)
	SYT7	Uncharacterized protein. (686 aa)
	PLD4	Phospholipase D family member 4. (515 aa)
	ATP7A	ATPase copper transporting alpha. (1500 aa)
	CLCN3	Chloride channel protein. (811 aa)
	RAB39A	RAB39A, member RAS oncogene family. (217 aa)
	ADAM8	ADAM metallopeptidase domain 8. (816 aa)
	ATAD1	ATPase family AAA domain containing 1; Belongs to the AAA ATPase family. (363 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	CD36	ENSPPAP00000035173	ENSPPAP00000001139	ATP binding cassette subfamily A member 1.	CD36 molecule; Belongs to the CD36 family.	0.635
ANXA11	ANXA3	ENSPPAP00000025677	ENSPPAP00000020650	Annexin.	Annexin.	0.429
ANXA3	ANXA11	ENSPPAP00000020650	ENSPPAP00000025677	Annexin.	Annexin.	0.429
APPL1	APPL2	ENSPPAP00000029773	ENSPPAP00000038121	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.980
APPL1	ENSPPAP00000021549	ENSPPAP00000029773	ENSPPAP00000021549	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Uncharacterized protein.	0.758
APPL1	INPP5B	ENSPPAP00000029773	ENSPPAP00000001903	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Inositol polyphosphate-5-phosphatase B.	0.518
APPL1	OCRL	ENSPPAP00000029773	ENSPPAP00000005460	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	OCRL inositol polyphosphate-5-phosphatase.	0.788
APPL1	RAB11B	ENSPPAP00000029773	ENSPPAP00000010776	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Uncharacterized protein.	0.556
APPL1	RAB20	ENSPPAP00000029773	ENSPPAP00000020436	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	RAB20, member RAS oncogene family.	0.758
APPL1	RAB22A	ENSPPAP00000029773	ENSPPAP00000015395	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	RAB22A, member RAS oncogene family.	0.758
APPL1	RAB31	ENSPPAP00000029773	ENSPPAP00000005824	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	RAB31, member RAS oncogene family.	0.758
APPL2	APPL1	ENSPPAP00000038121	ENSPPAP00000029773	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.980
APPL2	ENSPPAP00000021549	ENSPPAP00000038121	ENSPPAP00000021549	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Uncharacterized protein.	0.758
APPL2	RAB11B	ENSPPAP00000038121	ENSPPAP00000010776	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Uncharacterized protein.	0.556
APPL2	RAB20	ENSPPAP00000038121	ENSPPAP00000020436	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	RAB20, member RAS oncogene family.	0.758
APPL2	RAB22A	ENSPPAP00000038121	ENSPPAP00000015395	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	RAB22A, member RAS oncogene family.	0.758
APPL2	RAB31	ENSPPAP00000038121	ENSPPAP00000005824	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	RAB31, member RAS oncogene family.	0.758
ATP6V0A1	ATP6V0A2	ENSPPAP00000023033	ENSPPAP00000027494	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.992
ATP6V0A1	ATP6V0A4	ENSPPAP00000023033	ENSPPAP00000018029	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.985
ATP6V0A1	ATP6V0B	ENSPPAP00000023033	ENSPPAP00000033740	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family.	0.997