STRINGSTRING
SHB SHB SOCS5 SOCS5 ZAP70 ZAP70 SOCS4 SOCS4 MATK MATK PIK3R3 PIK3R3 BLK BLK STAP2 STAP2 JAK1 JAK1 SOCS3 SOCS3 CRKL CRKL JAK2 JAK2 GRB10 GRB10 SHF SHF SH2D5 SH2D5 VAV3 VAV3 ENSPPAP00000006969 ENSPPAP00000006969 SH2D3C SH2D3C GRAP2 GRAP2 SOCS7 SOCS7 SHD SHD PTPN6 PTPN6 TNS3 TNS3 PTK6 PTK6 GRB2 GRB2 PIK3R2 PIK3R2 TNS4 TNS4 CSK CSK SHC3 SHC3 NCK1 NCK1 GRAPL GRAPL BCAR3 BCAR3 SH2D4A SH2D4A FGR FGR STAT6 STAT6 CRK CRK SH2D2A SH2D2A TEC TEC LYN LYN INPPL1 INPPL1 ABL2 ABL2 SHC2 SHC2 DAPP1 DAPP1 STAT5A STAT5A PIK3R1 PIK3R1 SHC4 SHC4 SLA SLA STAT2 STAT2 SOCS2 SOCS2 TNS1 TNS1 SH2B3 SH2B3 STAT3 STAT3 SRC SRC BLNK BLNK BMX BMX GRAP GRAP STAT5B STAT5B STAT1 STAT1 PLCG2 PLCG2 CISH CISH FER FER SH2D1A SH2D1A RIN3 RIN3 TYK2 TYK2 YES1 YES1 BTK BTK STAT4 STAT4 CLNK CLNK HCK HCK SH2D3A SH2D3A NCK2 NCK2 SYK SYK FRK FRK SH2D6 SH2D6 ENSPPAP00000029143 ENSPPAP00000029143 VAV2 VAV2 TXK TXK RIN2 RIN2 SUPT6H SUPT6H SLA2 SLA2 VAV1 VAV1 SH3BP2 SH3BP2 ABL1 ABL1 STAP1 STAP1 FYN FYN SH2B1 SH2B1 ENSPPAP00000025160 ENSPPAP00000025160 PTPN11 PTPN11 LCP2 LCP2 TNS2 TNS2 FES FES ENSPPAP00000024034 ENSPPAP00000024034 RIN1 RIN1 GRB14 GRB14 SOCS6 SOCS6 SRMS SRMS GRB7 GRB7 HSH2D HSH2D PLCG1 PLCG1 CHN2 CHN2 ITK ITK RASA1 RASA1 LCK LCK INPP5D INPP5D SHE SHE SHC1 SHC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SHBSH2 domain-containing protein. (285 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
MATKTyrosine-protein kinase. (514 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
BLKTyrosine-protein kinase. (505 aa)
STAP2Signal transducing adaptor family member 2. (407 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
JAK2Tyrosine-protein kinase. (1143 aa)
GRB10Growth factor receptor bound protein 10. (594 aa)
SHFSrc homology 2 domain containing F. (423 aa)
SH2D5SH2 domain containing 5. (423 aa)
VAV3Vav guanine nucleotide exchange factor 3. (917 aa)
ENSPPAP00000006969Uncharacterized protein. (584 aa)
SH2D3CSH2 domain containing 3C. (860 aa)
GRAP2GRB2 related adaptor protein 2. (330 aa)
SOCS7Suppressor of cytokine signaling 7. (518 aa)
SHDSrc homology 2 domain containing transforming protein D. (340 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (603 aa)
TNS3Tensin 3. (1445 aa)
PTK6Tyrosine-protein kinase. (451 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R2Uncharacterized protein. (663 aa)
TNS4Tensin 4. (715 aa)
CSKTyrosine-protein kinase. (450 aa)
SHC3SHC adaptor protein 3. (501 aa)
NCK1Cytoplasmic protein. (377 aa)
GRAPLGRB2 related adaptor protein like. (100 aa)
BCAR3BCAR3 adaptor protein, NSP family member. (826 aa)
SH2D4ASH2 domain containing 4A. (454 aa)
FGRTyrosine-protein kinase. (529 aa)
STAT6Signal transducer and activator of transcription. (852 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
SH2D2ASH2 domain containing 2A. (398 aa)
TECTyrosine-protein kinase. (631 aa)
LYNTyrosine-protein kinase. (526 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1253 aa)
ABL2Tyrosine-protein kinase. (1131 aa)
SHC2Uncharacterized protein. (539 aa)
DAPP1Dual adaptor of phosphotyrosine and 3-phosphoinositides 1. (280 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
SHC4SHC adaptor protein 4. (630 aa)
SLASrc like adaptor. (293 aa)
STAT2Signal transducer and activator of transcription. (853 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
TNS1Tensin 1. (1740 aa)
SH2B3SH2 domain-containing protein. (373 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
SRCTyrosine-protein kinase. (458 aa)
BLNKB cell linker. (417 aa)
BMXTyrosine-protein kinase. (679 aa)
GRAPUncharacterized protein. (158 aa)
STAT5BSignal transducer and activator of transcription. (789 aa)
STAT1Signal transducer and activator of transcription. (759 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
CISHCytokine inducible SH2 containing protein. (275 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (798 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (128 aa)
RIN3Ras and Rab interactor 3. (982 aa)
TYK2Tyrosine-protein kinase. (1190 aa)
YES1Tyrosine-protein kinase. (548 aa)
BTKTyrosine-protein kinase. (693 aa)
STAT4Signal transducer and activator of transcription. (742 aa)
CLNKCytokine dependent hematopoietic cell linker. (443 aa)
HCKTyrosine-protein kinase. (526 aa)
SH2D3ASH2 domain containing 3A. (576 aa)
NCK2Cytoplasmic protein. (380 aa)
SYKTyrosine-protein kinase. (635 aa)
FRKTyrosine-protein kinase. (505 aa)
SH2D6SH2 domain-containing protein. (143 aa)
ENSPPAP00000029143Uncharacterized protein. (511 aa)
VAV2Vav guanine nucleotide exchange factor 2. (810 aa)
TXKTyrosine-protein kinase. (527 aa)
RIN2Ras and Rab interactor 2. (943 aa)
SUPT6HTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1726 aa)
SLA2Src like adaptor 2. (261 aa)
VAV1Vav guanine nucleotide exchange factor 1. (828 aa)
SH3BP2SH3 domain binding protein 2. (589 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
STAP1Signal transducing adaptor family member 1. (295 aa)
FYNTyrosine-protein kinase. (537 aa)
SH2B1SH2B adaptor protein 1. (756 aa)
ENSPPAP00000025160Tyrosine-protein kinase. (483 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
TNS2Tensin 2. (1419 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (827 aa)
ENSPPAP00000024034Uncharacterized protein. (541 aa)
RIN1Ras and Rab interactor 1. (783 aa)
GRB14Growth factor receptor bound protein 14. (530 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
SRMSTyrosine-protein kinase. (491 aa)
GRB7Growth factor receptor bound protein 7. (555 aa)
HSH2DHematopoietic SH2 domain containing. (352 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1248 aa)
CHN2Chimaerin; GTPase-activating protein for p21-rac. (468 aa)
ITKTyrosine-protein kinase. (620 aa)
RASA1RAS p21 protein activator 1. (1047 aa)
LCKTyrosine-protein kinase. (524 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1189 aa)
SHESrc homology 2 domain containing E. (483 aa)
SHC1SHC adaptor protein 1. (584 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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