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FGFR1 FGFR1 AATK AATK MAP3K20 MAP3K20 ZAP70 ZAP70 MATK MATK EPHA2 EPHA2 ROR1 ROR1 BLK BLK JAK1 JAK1 FLT3 FLT3 ARAF ARAF EPHA6 EPHA6 JAK2 JAK2 BMPR1B BMPR1B EPHB1 EPHB1 GUCY2C GUCY2C DDR1 DDR1 ANKK1 ANKK1 MUSK MUSK IGF1R IGF1R MAP3K9 MAP3K9 MAP3K7 MAP3K7 IRAK4 IRAK4 RYK RYK PTK6 PTK6 INSR INSR CSK CSK MAP3K11 MAP3K11 FGR FGR ILK ILK EPHA7 EPHA7 NEK7 NEK7 TEC TEC ENSPPAP00000014225 ENSPPAP00000014225 MERTK MERTK LYN LYN NPR2 NPR2 TNK1 TNK1 DDR2 DDR2 ENSPPAP00000015671 ENSPPAP00000015671 LCK LCK MST1R MST1R ITK ITK KSR1 KSR1 PDGFRA PDGFRA EPHA3 EPHA3 SRMS SRMS LMTK2 LMTK2 EPHB6 EPHB6 TEX14 TEX14 KIT KIT EPHB2 EPHB2 INSRR INSRR LTK LTK MAP3K13 MAP3K13 KSR2 KSR2 DSTYK DSTYK RET RET EPHA1 EPHA1 EPHB4 EPHB4 FGFR3 FGFR3 EPHB3 EPHB3 TEK TEK ROR2 ROR2 NTRK1 NTRK1 FGFR2 FGFR2 RAF1 RAF1 STYK1 STYK1 FES FES ERBB3 ERBB3 NPR1 NPR1 ACVRL1 ACVRL1 ENSPPAP00000025160 ENSPPAP00000025160 FYN FYN NRBP1 NRBP1 ACVR1C ACVR1C EPHA5 EPHA5 BRAF BRAF ENSPPAP00000026051 ENSPPAP00000026051 ABL1 ABL1 POMK POMK ENSPPAP00000026690 ENSPPAP00000026690 TIE1 TIE1 FGFR4 FGFR4 ACVR1 ACVR1 PRKD2 PRKD2 TXK TXK PDGFRB PDGFRB FRK FRK SYK SYK AXL AXL NTRK2 NTRK2 HCK HCK MET MET PTK2B PTK2B ENSPPAP00000030502 ENSPPAP00000030502 GUCY2D GUCY2D FPGT-TNNI3K FPGT-TNNI3K BTK BTK YES1 YES1 TYK2 TYK2 TESK1 TESK1 PTK7 PTK7 TYRO3 TYRO3 FER FER BMPR1A BMPR1A ROS1 ROS1 BMX BMX LIMK1 LIMK1 MAP3K12 MAP3K12 SRC SRC EPHA8 EPHA8 JAK3 JAK3 ERBB2 ERBB2 ERBB4 ERBB4 CSF1R CSF1R EPHA10 EPHA10 FLT4 FLT4 MLKL MLKL NTRK3 NTRK3 KDR KDR GUCY2F GUCY2F PTK2 PTK2 ALK ALK TGFBR2 TGFBR2 ABL2 ABL2 RIPK2 RIPK2 MAP3K10 MAP3K10 EPHA4 EPHA4 EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGFR1Fibroblast growth factor receptor. (812 aa)
AATKApoptosis associated tyrosine kinase; Belongs to the globin family. (1374 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (803 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
MATKTyrosine-protein kinase. (514 aa)
EPHA2EPH receptor A2. (976 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
BLKTyrosine-protein kinase. (505 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (978 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
EPHA6EPH receptor A6. (980 aa)
JAK2Tyrosine-protein kinase. (1143 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
EPHB1EPH receptor B1. (984 aa)
GUCY2CGuanylate cyclase. (1052 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (920 aa)
ANKK1Ankyrin repeat and kinase domain containing 1. (689 aa)
MUSKMuscle associated receptor tyrosine kinase. (879 aa)
IGF1RTyrosine-protein kinase receptor. (1389 aa)
MAP3K9Mitogen-activated protein kinase kinase kinase 9. (1117 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
RYKUncharacterized protein. (475 aa)
PTK6Tyrosine-protein kinase. (451 aa)
INSRTyrosine-protein kinase receptor. (1362 aa)
CSKTyrosine-protein kinase. (450 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase 11. (833 aa)
FGRTyrosine-protein kinase. (529 aa)
ILKIntegrin linked kinase. (533 aa)
EPHA7EPH receptor A7. (974 aa)
NEK7NIMA related kinase 7; Belongs to the protein kinase superfamily. (302 aa)
TECTyrosine-protein kinase. (631 aa)
ENSPPAP00000014225Protein kinase domain-containing protein. (433 aa)
MERTKMER proto-oncogene, tyrosine kinase. (966 aa)
LYNTyrosine-protein kinase. (526 aa)
NPR2Guanylate cyclase. (1047 aa)
TNK1Tyrosine kinase non receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (666 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
ENSPPAP00000015671Protein kinase domain-containing protein. (414 aa)
LCKTyrosine-protein kinase. (524 aa)
MST1RMacrophage stimulating 1 receptor. (1400 aa)
ITKTyrosine-protein kinase. (620 aa)
KSR1Kinase suppressor of ras 1. (856 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
EPHA3EPH receptor A3. (983 aa)
SRMSTyrosine-protein kinase. (491 aa)
LMTK2Lemur tyrosine kinase 2. (1503 aa)
EPHB6EPH receptor B6. (1021 aa)
TEX14Testis expressed 14, intercellular bridge forming factor. (1491 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
EPHB2EPH receptor B2. (1039 aa)
INSRRTyrosine-protein kinase receptor. (1297 aa)
LTKTyrosine-protein kinase receptor. (864 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (986 aa)
KSR2Kinase suppressor of ras 2. (950 aa)
DSTYKDual serine/threonine and tyrosine protein kinase. (929 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1116 aa)
EPHA1EPH receptor A1. (965 aa)
EPHB4EPH receptor B4. (987 aa)
FGFR3Fibroblast growth factor receptor. (780 aa)
EPHB3EPH receptor B3. (1031 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (982 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
FGFR2Fibroblast growth factor receptor. (822 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
STYK1Serine/threonine/tyrosine kinase 1. (422 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (827 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1344 aa)
NPR1Guanylate cyclase. (1060 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
ENSPPAP00000025160Tyrosine-protein kinase. (483 aa)
FYNTyrosine-protein kinase. (537 aa)
NRBP1Nuclear receptor binding protein 1. (543 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
EPHA5Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (370 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (766 aa)
ENSPPAP00000026051Protein kinase domain-containing protein. (337 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
POMKProtein O-mannose kinase. (350 aa)
ENSPPAP00000026690Protein kinase domain-containing protein. (1250 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
FGFR4Fibroblast growth factor receptor. (802 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (826 aa)
TXKTyrosine-protein kinase. (527 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
FRKTyrosine-protein kinase. (505 aa)
SYKTyrosine-protein kinase. (635 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
HCKTyrosine-protein kinase. (526 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1413 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ENSPPAP00000030502Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (849 aa)
GUCY2DGuanylate cyclase. (981 aa)
FPGT-TNNI3KFPGT-TNNI3K readthrough. (949 aa)
BTKTyrosine-protein kinase. (693 aa)
YES1Tyrosine-protein kinase. (548 aa)
TYK2Tyrosine-protein kinase. (1190 aa)
TESK1Testis associated actin remodelling kinase 1. (625 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
TYRO3TYRO3 protein tyrosine kinase. (890 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (798 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ROS1Tyrosine-protein kinase receptor. (2347 aa)
BMXTyrosine-protein kinase. (679 aa)
LIMK1LIM domain kinase 1. (677 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (893 aa)
SRCTyrosine-protein kinase. (458 aa)
EPHA8EPH receptor A8. (997 aa)
JAK3Tyrosine-protein kinase. (1090 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
ERBB4Receptor protein-tyrosine kinase. (1386 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
EPHA10EPH receptor A10. (918 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1321 aa)
MLKLMixed lineage kinase domain like pseudokinase. (471 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
GUCY2FGuanylate cyclase. (1108 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1113 aa)
ALKTyrosine-protein kinase receptor. (1312 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (570 aa)
ABL2Tyrosine-protein kinase. (1131 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase 10. (793 aa)
EPHA4EPH receptor A4. (986 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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