(30 nodes) Ras guanine-nucleotide exchange factors catalytic domain network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PLCE1	Phosphoinositide phospholipase C. (2276 aa)
	RASGEF1B	RasGEF domain family member 1B. (560 aa)
	RGL2	Ral guanine nucleotide dissociation stimulator like 2. (777 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
	RALGPS2	Ral GEF with PH domain and SH3 binding motif 2. (583 aa)
	RASGRF2	Ras protein specific guanine nucleotide releasing factor 2. (1237 aa)
	RASGRP4	RAS guanyl releasing protein 4. (699 aa)
	BCAR3	BCAR3 adaptor protein, NSP family member. (826 aa)
	RGL4	Ras-GEF domain-containing protein. (588 aa)
	RAPGEF6	Uncharacterized protein. (1609 aa)
	RASGEF1A	RasGEF domain family member 1A. (489 aa)
	RASGRF1	Ras protein specific guanine nucleotide releasing factor 1. (1270 aa)
	RALGPS1	Ral GEF with PH domain and SH3 binding motif 1. (557 aa)
	SH2D3C	SH2 domain containing 3C. (860 aa)
	RAPGEF2	Rap guanine nucleotide exchange factor 2. (1611 aa)
	RAPGEF3	Rap guanine nucleotide exchange factor 3. (905 aa)
	RASGEF1C	Ras-GEF domain-containing protein. (315 aa)
	RALGDS	Uncharacterized protein. (913 aa)
	RAPGEF5	Rap guanine nucleotide exchange factor 5. (721 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1325 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (1095 aa)
	RGL3	Ral guanine nucleotide dissociation stimulator like 3. (699 aa)
	RAPGEFL1	Rap guanine nucleotide exchange factor like 1. (603 aa)
	RASGRP2	RAS guanyl releasing protein 2. (610 aa)
	RASGRP1	RAS guanyl releasing protein 1. (843 aa)
	KNDC1	Kinase non-catalytic C-lobe domain containing 1. (1754 aa)
	RAPGEF4	Rap guanine nucleotide exchange factor 4. (923 aa)
	SH2D3A	SH2 domain containing 3A. (576 aa)
	RGL1	Ral guanine nucleotide dissociation stimulator like 1. (803 aa)
	RASGRP3	RAS guanyl releasing protein 3. (690 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCAR3	SH2D3C	ENSPPAP00000011880	ENSPPAP00000007438	BCAR3 adaptor protein, NSP family member.	SH2 domain containing 3C.	0.461
RALGDS	RGL4	ENSPPAP00000037463	ENSPPAP00000012225	Uncharacterized protein.	Ras-GEF domain-containing protein.	0.903
RAPGEF1	SOS1	ENSPPAP00000035151	ENSPPAP00000008514	Rap guanine nucleotide exchange factor 1.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.550
RAPGEF1	SOS2	ENSPPAP00000035151	ENSPPAP00000035804	Rap guanine nucleotide exchange factor 1.	SOS Ras/Rho guanine nucleotide exchange factor 2.	0.409
RAPGEF2	RAPGEF6	ENSPPAP00000014306	ENSPPAP00000006205	Rap guanine nucleotide exchange factor 2.	Uncharacterized protein.	0.901
RAPGEF2	RASGRF1	ENSPPAP00000014306	ENSPPAP00000006704	Rap guanine nucleotide exchange factor 2.	Ras protein specific guanine nucleotide releasing factor 1.	0.400
RAPGEF2	RASGRF2	ENSPPAP00000014306	ENSPPAP00000041875	Rap guanine nucleotide exchange factor 2.	Ras protein specific guanine nucleotide releasing factor 2.	0.406
RAPGEF3	RAPGEF4	ENSPPAP00000041160	ENSPPAP00000030207	Rap guanine nucleotide exchange factor 3.	Rap guanine nucleotide exchange factor 4.	0.949
RAPGEF4	RAPGEF3	ENSPPAP00000030207	ENSPPAP00000041160	Rap guanine nucleotide exchange factor 4.	Rap guanine nucleotide exchange factor 3.	0.949
RAPGEF5	RAPGEFL1	ENSPPAP00000036954	ENSPPAP00000034157	Rap guanine nucleotide exchange factor 5.	Rap guanine nucleotide exchange factor like 1.	0.461
RAPGEF6	RAPGEF2	ENSPPAP00000006205	ENSPPAP00000014306	Uncharacterized protein.	Rap guanine nucleotide exchange factor 2.	0.901
RAPGEFL1	RAPGEF5	ENSPPAP00000034157	ENSPPAP00000036954	Rap guanine nucleotide exchange factor like 1.	Rap guanine nucleotide exchange factor 5.	0.461
RASGEF1A	RASGRP1	ENSPPAP00000000242	ENSPPAP00000032843	RasGEF domain family member 1A.	RAS guanyl releasing protein 1.	0.631
RASGEF1A	RASGRP2	ENSPPAP00000000242	ENSPPAP00000033552	RasGEF domain family member 1A.	RAS guanyl releasing protein 2.	0.693
RASGEF1A	RASGRP4	ENSPPAP00000000242	ENSPPAP00000042502	RasGEF domain family member 1A.	RAS guanyl releasing protein 4.	0.737
RASGEF1A	SOS1	ENSPPAP00000000242	ENSPPAP00000008514	RasGEF domain family member 1A.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.529
RASGRF1	RAPGEF2	ENSPPAP00000006704	ENSPPAP00000014306	Ras protein specific guanine nucleotide releasing factor 1.	Rap guanine nucleotide exchange factor 2.	0.400
RASGRF1	RASGRF2	ENSPPAP00000006704	ENSPPAP00000041875	Ras protein specific guanine nucleotide releasing factor 1.	Ras protein specific guanine nucleotide releasing factor 2.	0.991
RASGRF2	RAPGEF2	ENSPPAP00000041875	ENSPPAP00000014306	Ras protein specific guanine nucleotide releasing factor 2.	Rap guanine nucleotide exchange factor 2.	0.406
RASGRF2	RASGRF1	ENSPPAP00000041875	ENSPPAP00000006704	Ras protein specific guanine nucleotide releasing factor 2.	Ras protein specific guanine nucleotide releasing factor 1.	0.991