(56 nodes) Short-chain dehydrogenase/reductase SDR network (Pan paniscus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PECR	Peroxisomal trans-2-enoyl-CoA reductase. (321 aa)
	DHRS13	Dehydrogenase/reductase 13. (316 aa)
	DHRS9	Dehydrogenase/reductase 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (338 aa)
	DHRS3	Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
	HSD11B1	Hydroxysteroid 11-beta dehydrogenase 1. (292 aa)
	DHRS7B	Dehydrogenase/reductase 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (325 aa)
	HSD17B13	Hydroxysteroid 17-beta dehydrogenase 13; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (300 aa)
	HSD17B1	Hydroxysteroid 17-beta dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (351 aa)
	HSD17B4	Hydroxysteroid 17-beta dehydrogenase 4. (761 aa)
	RDH12	Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (316 aa)
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	HSD17B12	Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)
	LOC100976049	Uncharacterized protein. (280 aa)
	HSD17B3	Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
	SPR	Sepiapterin reductase. (261 aa)
	HPGD	15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
	BDH2	3-hydroxybutyrate dehydrogenase 2. (245 aa)
	HSDL1	Hydroxysteroid dehydrogenase like 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (330 aa)
	HSD17B14	Hydroxysteroid 17-beta dehydrogenase 14. (270 aa)
	WWOX	WW domain containing oxidoreductase. (414 aa)
	DHRS1	Dehydrogenase/reductase 1. (313 aa)
	ENSPPAP00000030022	Uncharacterized protein. (100 aa)
	HSD17B2	Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (387 aa)
	DHRS4	Dehydrogenase/reductase 4. (270 aa)
	CBR4	Carbonyl reductase 4. (237 aa)
	RDH11	Retinol dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (318 aa)
	DCXR	Dicarbonyl and L-xylulose reductase. (244 aa)
	QDPR	Quinoid dihydropteridine reductase. (244 aa)
	DECR1	2,4-dienoyl-CoA reductase 1. (335 aa)
	DECR2	2,4-dienoyl-CoA reductase 2. (250 aa)
	HSD11B2	Hydroxysteroid 11-beta dehydrogenase 2. (379 aa)
	LOC100984876	Uncharacterized protein. (372 aa)
	RDH8	Retinol dehydrogenase 8; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (329 aa)
	BDH1	3-hydroxybutyrate dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (343 aa)
	RDH14	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (290 aa)
	HSD17B10	Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa)
	SDR16C5	Short chain dehydrogenase/reductase family 16C member 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (328 aa)
	CBR1	Carbonyl reductase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa)
	HSD17B8	Hydroxysteroid 17-beta dehydrogenase 8. (261 aa)
	KDSR	3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (296 aa)
	DHRS11	Dehydrogenase/reductase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (234 aa)
	DHRS12	Dehydrogenase/reductase 12. (328 aa)
	DHRSX	Dehydrogenase/reductase X-linked. (293 aa)
	DHRS7C	Dehydrogenase/reductase 7C; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)
	HSD17B6	Hydroxysteroid 17-beta dehydrogenase 6; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
	HSD17B7	Hydroxysteroid 17-beta dehydrogenase 7. (335 aa)
	ENSPPAP00000009028	Uncharacterized protein. (217 aa)
	DHRS7	Dehydrogenase/reductase 7; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (339 aa)
	RDH13	Retinol dehydrogenase 13; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (331 aa)
	HSD11B1L	Hydroxysteroid 11-beta dehydrogenase 1 like. (334 aa)
	RDH5	Retinol dehydrogenase 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (318 aa)
	CBR3	Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa)
	HSD17B11	Hydroxysteroid 17-beta dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (300 aa)
	RDH16	Retinol dehydrogenase 16; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
	SDR9C7	Short chain dehydrogenase/reductase family 9C member 7; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (313 aa)
	HSDL2	Hydroxysteroid dehydrogenase like 2. (419 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDH1	BDH2	ENSPPAP00000020349	ENSPPAP00000032941	3-hydroxybutyrate dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	3-hydroxybutyrate dehydrogenase 2.	0.960
BDH1	DECR2	ENSPPAP00000020349	ENSPPAP00000025432	3-hydroxybutyrate dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	2,4-dienoyl-CoA reductase 2.	0.402
BDH1	ENSPPAP00000030022	ENSPPAP00000020349	ENSPPAP00000030022	3-hydroxybutyrate dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Uncharacterized protein.	0.553
BDH1	HSD11B1	ENSPPAP00000020349	ENSPPAP00000041108	3-hydroxybutyrate dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Hydroxysteroid 11-beta dehydrogenase 1.	0.500
BDH2	BDH1	ENSPPAP00000032941	ENSPPAP00000020349	3-hydroxybutyrate dehydrogenase 2.	3-hydroxybutyrate dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.960
BDH2	CBR4	ENSPPAP00000032941	ENSPPAP00000028845	3-hydroxybutyrate dehydrogenase 2.	Carbonyl reductase 4.	0.413
BDH2	HSD17B3	ENSPPAP00000032941	ENSPPAP00000034904	3-hydroxybutyrate dehydrogenase 2.	Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.517
BDH2	HSD17B8	ENSPPAP00000032941	ENSPPAP00000018302	3-hydroxybutyrate dehydrogenase 2.	Hydroxysteroid 17-beta dehydrogenase 8.	0.404
CBR1	CBR3	ENSPPAP00000018365	ENSPPAP00000003368	Carbonyl reductase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.973
CBR1	SPR	ENSPPAP00000018365	ENSPPAP00000034663	Carbonyl reductase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Sepiapterin reductase.	0.953
CBR3	CBR1	ENSPPAP00000003368	ENSPPAP00000018365	Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Carbonyl reductase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.973
CBR3	CBR4	ENSPPAP00000003368	ENSPPAP00000028845	Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Carbonyl reductase 4.	0.459
CBR3	HSD17B2	ENSPPAP00000003368	ENSPPAP00000029894	Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.475
CBR4	BDH2	ENSPPAP00000028845	ENSPPAP00000032941	Carbonyl reductase 4.	3-hydroxybutyrate dehydrogenase 2.	0.413
CBR4	CBR3	ENSPPAP00000028845	ENSPPAP00000003368	Carbonyl reductase 4.	Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.459
CBR4	DHRS4	ENSPPAP00000028845	ENSPPAP00000029435	Carbonyl reductase 4.	Dehydrogenase/reductase 4.	0.451
CBR4	ENSPPAP00000009028	ENSPPAP00000028845	ENSPPAP00000009028	Carbonyl reductase 4.	Uncharacterized protein.	0.466
CBR4	HSD17B3	ENSPPAP00000028845	ENSPPAP00000034904	Carbonyl reductase 4.	Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.408
CBR4	HSD17B8	ENSPPAP00000028845	ENSPPAP00000018302	Carbonyl reductase 4.	Hydroxysteroid 17-beta dehydrogenase 8.	0.999
CBR4	HSDL2	ENSPPAP00000028845	ENSPPAP00000001088	Carbonyl reductase 4.	Hydroxysteroid dehydrogenase like 2.	0.430