STRINGSTRING
RFC3 RFC3 SPATA5L1 SPATA5L1 RFC5 RFC5 ABCC11 ABCC11 ORC4 ORC4 AK9 AK9 ABCB9 ABCB9 PSMC5 PSMC5 ATAD1 ATAD1 SPATA5 SPATA5 DNAH8 DNAH8 DNAH11 DNAH11 ATAD2 ATAD2 ENSPPAP00000040268 ENSPPAP00000040268 KATNA1 KATNA1 ABCA2 ABCA2 PSMC3 PSMC3 RFC1 RFC1 RAD51 RAD51 TOR2A TOR2A PEX1 PEX1 LOC100985670 LOC100985670 ABCF3 ABCF3 TOR4A TOR4A ABCD4 ABCD4 RFC4 RFC4 ABCC2 ABCC2 VCP VCP RAD51B RAD51B CLPX CLPX CFTR CFTR ABCA1 ABCA1 ENSPPAP00000035076 ENSPPAP00000035076 DYNC2H1 DYNC2H1 RUVBL1 RUVBL1 YME1L1 YME1L1 ABCA8 ABCA8 NAIP NAIP ABCB5 ABCB5 ABCD3 ABCD3 DMC1 DMC1 DNAH7 DNAH7 ABCA7 ABCA7 ABCD1 ABCD1 DNAH2 DNAH2 CDC6 CDC6 RUVBL2 RUVBL2 DNAH5 DNAH5 ABCB4 ABCB4 LONP1 LONP1 ENSPPAP00000029830 ENSPPAP00000029830 ABCC3 ABCC3 HELZ2 HELZ2 ENSPPAP00000029035 ENSPPAP00000029035 ATP5F1B ATP5F1B ORC1 ORC1 PEX6 PEX6 SPAST SPAST ABCF1 ABCF1 DNAH3 DNAH3 ABCB1 ABCB1 NAV3 NAV3 DYNC1H1 DYNC1H1 ABCA4 ABCA4 LOC100972859 LOC100972859 DNAH6 DNAH6 MCM7 MCM7 WRNIP1 WRNIP1 ABCC9 ABCC9 TAP2 TAP2 NAV2 NAV2 MCM8 MCM8 PSMC6 PSMC6 VPS4B VPS4B DNAH12 DNAH12 DNAH14 DNAH14 KATNAL1 KATNAL1 ATAD2B ATAD2B FIGN FIGN NAV1 NAV1 LONP2 LONP2 ABCB11 ABCB11 ENSPPAP00000019086 ENSPPAP00000019086 ABCB8 ABCB8 ATAD3C ATAD3C ABCA6 ABCA6 PSMC4 PSMC4 ABCB7 ABCB7 ABCB6 ABCB6 NSF NSF SRPRA SRPRA SPG7 SPG7 ASCC3 ASCC3 NVL NVL ABCD2 ABCD2 ATAD5 ATAD5 NTPCR NTPCR ABCA10 ABCA10 ABCA3 ABCA3 LOC100979126 LOC100979126 PSMC1 PSMC1 ABCC5 ABCC5 TAP1 TAP1 BCS1L BCS1L NUBP1 NUBP1 ABCC12 ABCC12 LOC100970330 LOC100970330 MCM3 MCM3 CHTF18 CHTF18 DNAH10 DNAH10 LOC100969990 LOC100969990 PSMC2 PSMC2 ENSPPAP00000008466 ENSPPAP00000008466 IGHMBP2 IGHMBP2 MCM9 MCM9 ABCG1 ABCG1 ABCA9 ABCA9 ABCA12 ABCA12 ABCA5 ABCA5 ABCG5 ABCG5 ABCC8 ABCC8 ABCG4 ABCG4 RAD51D RAD51D ABCG2 ABCG2 FIGNL2 FIGNL2 GPN1 GPN1 KATNAL2 KATNAL2 SRP54 SRP54 CLPB CLPB RNF213 RNF213 ABCC4 ABCC4 ABCF2 ABCF2 ABCB10 ABCB10 ABCE1 ABCE1 MDN1 MDN1 ABCG8 ABCG8 VWA8 VWA8 AFG3L2 AFG3L2 ABCA13 ABCA13 ABCC10 ABCC10 ENSPPAP00000000083 ENSPPAP00000000083
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RFC3Replication factor C subunit 3. (356 aa)
SPATA5L1Spermatogenesis associated 5 like 1; Belongs to the AAA ATPase family. (669 aa)
RFC5Replication factor C subunit 5. (354 aa)
ABCC11ATP binding cassette subfamily C member 11. (1385 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
AK9Adenylate kinase 9. (1910 aa)
ABCB9ATP binding cassette subfamily B member 9. (766 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
ATAD1ATPase family AAA domain containing 1; Belongs to the AAA ATPase family. (363 aa)
SPATA5Spermatogenesis associated 5. (744 aa)
DNAH8Dynein axonemal heavy chain 8. (4707 aa)
DNAH11Dynein axonemal heavy chain 11. (4491 aa)
ATAD2ATPase family AAA domain containing 2. (1387 aa)
ENSPPAP00000040268Uncharacterized protein. (374 aa)
KATNA1Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal p [...] (491 aa)
ABCA2ATP binding cassette subfamily A member 2. (2446 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
RFC1Replication factor C subunit 1. (1148 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa)
TOR2ATorsin. (321 aa)
PEX1Peroxisomal biogenesis factor 1. (1283 aa)
LOC100985670Uncharacterized protein. (1248 aa)
ABCF3ATP binding cassette subfamily F member 3. (709 aa)
TOR4ATorsin family 4 member A. (359 aa)
ABCD4ATP binding cassette subfamily D member 4. (606 aa)
RFC4Replication factor C subunit 4. (363 aa)
ABCC2ATP binding cassette subfamily C member 2. (1537 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
RAD51BRAD51 paralog B. (359 aa)
CLPXCaseinolytic mitochondrial matrix peptidase chaperone subunit. (633 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1480 aa)
ABCA1ATP binding cassette subfamily A member 1. (2264 aa)
ENSPPAP00000035076AAA domain-containing protein. (543 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4314 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
YME1L1YME1 like 1 ATPase. (773 aa)
ABCA8ATP binding cassette subfamily A member 8. (1621 aa)
NAIPNLR family apoptosis inhibitory protein. (1403 aa)
ABCB5ATP binding cassette subfamily B member 5. (1244 aa)
ABCD3ATP binding cassette subfamily D member 3. (659 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa)
DNAH7Dynein axonemal heavy chain 7. (3940 aa)
ABCA7ATP binding cassette subfamily A member 7. (2146 aa)
ABCD1ATP binding cassette subfamily D member 1. (745 aa)
DNAH2Dynein axonemal heavy chain 2. (4427 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
DNAH5Dynein axonemal heavy chain 5. (4446 aa)
ABCB4ATP binding cassette subfamily B member 4. (1279 aa)
LONP1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...] (943 aa)
ENSPPAP00000029830AAA domain-containing protein. (395 aa)
ABCC3ATP binding cassette subfamily C member 3. (1544 aa)
HELZ2Helicase with zinc finger 2. (2649 aa)
ENSPPAP00000029035AAA domain-containing protein. (392 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (529 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (859 aa)
PEX6Peroxisomal biogenesis factor 6. (952 aa)
SPASTSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (602 aa)
ABCF1ATP binding cassette subfamily F member 1. (829 aa)
DNAH3Dynein axonemal heavy chain 3. (4116 aa)
ABCB1ATP binding cassette subfamily B member 1. (1220 aa)
NAV3Neuron navigator 3. (2385 aa)
DYNC1H1Dynein cytoplasmic 1 heavy chain 1. (4581 aa)
ABCA4ATP binding cassette subfamily A member 4. (2159 aa)
LOC100972859ABC transporter domain-containing protein. (192 aa)
DNAH6Dynein axonemal heavy chain 6. (4083 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
WRNIP1WRN helicase interacting protein 1. (572 aa)
ABCC9ATP binding cassette subfamily C member 9. (1549 aa)
TAP2Transporter 2, ATP binding cassette subfamily B member. (724 aa)
NAV2Neuron navigator 2. (2488 aa)
MCM8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (843 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (411 aa)
VPS4BVacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (446 aa)
DNAH12Uncharacterized protein. (3960 aa)
DNAH14Uncharacterized protein. (4161 aa)
KATNAL1Katanin p60 ATPase-containing subunit A-like 1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neur [...] (490 aa)
ATAD2BATPase family AAA domain containing 2B. (1458 aa)
FIGNFidgetin, microtubule severing factor; Belongs to the AAA ATPase family. (759 aa)
NAV1Neuron navigator 1. (1848 aa)
LONP2Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. (852 aa)
ABCB11ATP binding cassette subfamily B member 11. (1321 aa)
ENSPPAP00000019086Uncharacterized protein. (529 aa)
ABCB8ATP binding cassette subfamily B member 8. (735 aa)
ATAD3CATPase family AAA domain containing 3C. (401 aa)
ABCA6ATP binding cassette subfamily A member 6. (1617 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (421 aa)
ABCB7ATP binding cassette subfamily B member 7. (753 aa)
ABCB6ATP binding cassette subfamily B member 6 (Langereis blood group). (854 aa)
NSFN-ethylmaleimide sensitive factor, vesicle fusing ATPase. (744 aa)
SRPRASRP receptor subunit alpha. (638 aa)
SPG7SPG7 matrix AAA peptidase subunit, paraplegin. (795 aa)
ASCC3Activating signal cointegrator 1 complex subunit 3. (2202 aa)
NVLNuclear VCP like. (848 aa)
ABCD2ATP binding cassette subfamily D member 2. (740 aa)
ATAD5ATPase family AAA domain containing 5. (1832 aa)
NTPCRAAA domain-containing protein. (228 aa)
ABCA10ATP binding cassette subfamily A member 10. (1503 aa)
ABCA3ATP binding cassette subfamily A member 3. (1704 aa)
LOC100979126Uncharacterized protein; Belongs to the AAA ATPase family. (462 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
ABCC5ATP binding cassette subfamily C member 5. (1437 aa)
TAP1Transporter 1, ATP binding cassette subfamily B member. (808 aa)
BCS1LBCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone; Belongs to the AAA ATPase family. (419 aa)
NUBP1Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (320 aa)
ABCC12ATP binding cassette subfamily C member 12. (1359 aa)
LOC100970330Uncharacterized protein. (441 aa)
MCM3DNA helicase; Belongs to the MCM family. (840 aa)
CHTF18Chromosome transmission fidelity factor 18. (1047 aa)
DNAH10Dynein axonemal heavy chain 10. (4531 aa)
LOC100969990Uncharacterized protein. (659 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (432 aa)
ENSPPAP00000008466AAA domain-containing protein. (374 aa)
IGHMBP2Immunoglobulin mu DNA binding protein 2. (997 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1143 aa)
ABCG1ABC transporter domain-containing protein. (807 aa)
ABCA9ATP binding cassette subfamily A member 9. (1624 aa)
ABCA12ATP binding cassette subfamily A member 12. (2595 aa)
ABCA5ATP binding cassette subfamily A member 5. (1631 aa)
ABCG5ATP binding cassette subfamily G member 5. (651 aa)
ABCC8ATP binding cassette subfamily C member 8. (1582 aa)
ABCG4ATP binding cassette subfamily G member 4. (646 aa)
RAD51DRAD51 paralog D. (348 aa)
ABCG2ATP binding cassette subfamily G member 2 (Junior blood group). (655 aa)
FIGNL2Fidgetin like 2. (633 aa)
GPN1GPN-loop GTPase; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. (388 aa)
KATNAL2Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. (538 aa)
SRP54Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
CLPBClpB homolog, mitochondrial AAA ATPase chaperonin. (704 aa)
RNF213Ring finger protein 213. (5256 aa)
ABCC4ATP binding cassette subfamily C member 4. (1336 aa)
ABCF2Uncharacterized protein. (634 aa)
ABCB10ATP binding cassette subfamily B member 10. (609 aa)
ABCE1ATP binding cassette subfamily E member 1. (599 aa)
MDN1Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (5596 aa)
ABCG8ATP binding cassette subfamily G member 8. (673 aa)
VWA8Von Willebrand factor A domain containing 8. (1905 aa)
AFG3L2AFG3 like matrix AAA peptidase subunit 2. (797 aa)
ABCA13ATP binding cassette subfamily A member 13. (5032 aa)
ABCC10ATP binding cassette subfamily C member 10. (1496 aa)
ENSPPAP00000000083AAA domain-containing protein. (340 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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