(39 nodes) PTB/PI domain network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TNS4	Tensin 4. (715 aa)
	ANKS1A	Ankyrin repeat and sterile alpha motif domain containing 1A. (1130 aa)
	FAM43A	Family with sequence similarity 43 member A. (424 aa)
	MAPK8IP1	Mitogen-activated protein kinase 8 interacting protein 1. (713 aa)
	RABGAP1	RAB GTPase activating protein 1. (1062 aa)
	SH2D5	SH2 domain containing 5. (423 aa)
	NUMB	NUMB endocytic adaptor protein. (651 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1. (295 aa)
	APBA3	Amyloid beta precursor protein binding family A member 3. (575 aa)
	ANKS1B	Ankyrin repeat and sterile alpha motif domain containing 1B. (1167 aa)
	GULP1	GULP PTB domain containing engulfment adaptor 1. (304 aa)
	TNS3	Tensin 3. (1445 aa)
	SHC3	SHC adaptor protein 3. (501 aa)
	DAB2	DAB adaptor protein 2. (752 aa)
	MAPK8IP2	Mitogen-activated protein kinase 8 interacting protein 2. (692 aa)
	SHC1	SHC adaptor protein 1. (584 aa)
	DAB1	DAB adaptor protein 1. (588 aa)
	APBA2	Amyloid beta precursor protein binding family A member 2. (751 aa)
	CCM2	CCM2 scaffold protein. (530 aa)
	ENSPPAP00000021339	PID domain-containing protein. (181 aa)
	RGS12	Regulator of G protein signaling 12. (1446 aa)
	EPS8L2	EPS8 like 2. (716 aa)
	TNS2	Tensin 2. (1419 aa)
	NUMBL	NUMB like endocytic adaptor protein. (613 aa)
	APBB1	Amyloid beta precursor protein binding family B member 1. (772 aa)
	APBA1	Amyloid beta precursor protein binding family A member 1. (791 aa)
	APBB2	Amyloid beta precursor protein binding family B member 2. (738 aa)
	TBC1D1	TBC1 domain family member 1. (1168 aa)
	APPL1	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (709 aa)
	EPS8	Epidermal growth factor receptor pathway substrate 8. (822 aa)
	APBB3	Amyloid beta precursor protein binding family B member 3. (493 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	RABGAP1L	RAB GTPase activating protein 1 like. (815 aa)
	TNS1	Tensin 1. (1740 aa)
	NOS1AP	Nitric oxide synthase 1 adaptor protein. (506 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (647 aa)
	SHC4	SHC adaptor protein 4. (630 aa)
	TBC1D4	TBC1 domain family member 4. (1176 aa)
	SHC2	Uncharacterized protein. (539 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APBA1	APBB1	ENSPPAP00000028551	ENSPPAP00000025296	Amyloid beta precursor protein binding family A member 1.	Amyloid beta precursor protein binding family B member 1.	0.635
APBA1	APBB2	ENSPPAP00000028551	ENSPPAP00000029073	Amyloid beta precursor protein binding family A member 1.	Amyloid beta precursor protein binding family B member 2.	0.625
APBA2	APBB1	ENSPPAP00000017525	ENSPPAP00000025296	Amyloid beta precursor protein binding family A member 2.	Amyloid beta precursor protein binding family B member 1.	0.587
APBA2	APBB2	ENSPPAP00000017525	ENSPPAP00000029073	Amyloid beta precursor protein binding family A member 2.	Amyloid beta precursor protein binding family B member 2.	0.656
APBB1	APBA1	ENSPPAP00000025296	ENSPPAP00000028551	Amyloid beta precursor protein binding family B member 1.	Amyloid beta precursor protein binding family A member 1.	0.635
APBB1	APBA2	ENSPPAP00000025296	ENSPPAP00000017525	Amyloid beta precursor protein binding family B member 1.	Amyloid beta precursor protein binding family A member 2.	0.587
APBB1	APBB2	ENSPPAP00000025296	ENSPPAP00000029073	Amyloid beta precursor protein binding family B member 1.	Amyloid beta precursor protein binding family B member 2.	0.792
APBB1	DAB1	ENSPPAP00000025296	ENSPPAP00000017402	Amyloid beta precursor protein binding family B member 1.	DAB adaptor protein 1.	0.423
APBB1	MAPK8IP1	ENSPPAP00000025296	ENSPPAP00000002400	Amyloid beta precursor protein binding family B member 1.	Mitogen-activated protein kinase 8 interacting protein 1.	0.559
APBB2	APBA1	ENSPPAP00000029073	ENSPPAP00000028551	Amyloid beta precursor protein binding family B member 2.	Amyloid beta precursor protein binding family A member 1.	0.625
APBB2	APBA2	ENSPPAP00000029073	ENSPPAP00000017525	Amyloid beta precursor protein binding family B member 2.	Amyloid beta precursor protein binding family A member 2.	0.656
APBB2	APBB1	ENSPPAP00000029073	ENSPPAP00000025296	Amyloid beta precursor protein binding family B member 2.	Amyloid beta precursor protein binding family B member 1.	0.792
APPL1	APPL2	ENSPPAP00000029773	ENSPPAP00000038121	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.980
APPL1	GULP1	ENSPPAP00000029773	ENSPPAP00000008082	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	GULP PTB domain containing engulfment adaptor 1.	0.683
APPL1	LDLRAP1	ENSPPAP00000029773	ENSPPAP00000006982	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Low density lipoprotein receptor adaptor protein 1.	0.672
APPL2	APPL1	ENSPPAP00000038121	ENSPPAP00000029773	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.980
APPL2	GULP1	ENSPPAP00000038121	ENSPPAP00000008082	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	GULP PTB domain containing engulfment adaptor 1.	0.672
APPL2	LDLRAP1	ENSPPAP00000038121	ENSPPAP00000006982	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Low density lipoprotein receptor adaptor protein 1.	0.672
CCM2	ITGB1BP1	ENSPPAP00000021268	ENSPPAP00000032940	CCM2 scaffold protein.	Integrin subunit beta 1 binding protein 1.	0.923
DAB1	APBB1	ENSPPAP00000017402	ENSPPAP00000025296	DAB adaptor protein 1.	Amyloid beta precursor protein binding family B member 1.	0.423