(17 nodes) Tumour necrosis factor domain network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CD70	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (193 aa)
	TNFSF9	TNF superfamily member 9; Belongs to the tumor necrosis factor family. (253 aa)
	TNFSF8	TNF superfamily member 8; Belongs to the tumor necrosis factor family. (234 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
	TNFSF10	Tumor necrosis factor ligand superfamily member. (281 aa)
	LTB	Lymphotoxin beta; Belongs to the tumor necrosis factor family. (243 aa)
	LTA	Lymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa)
	TNFSF12	TNF superfamily member 12; Belongs to the tumor necrosis factor family. (236 aa)
	TNFSF14	TNF superfamily member 14; Belongs to the tumor necrosis factor family. (240 aa)
	EDA	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (223 aa)
	TNFSF11	Tumor necrosis factor ligand superfamily member. (317 aa)
	TNFSF4	TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
	FASLG	Fas ligand; Belongs to the tumor necrosis factor family. (280 aa)
	TNFSF15	TNF superfamily member 15. (251 aa)
	TNFSF13	TNF superfamily member 13; Belongs to the tumor necrosis factor family. (250 aa)
	TNFSF13B	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (285 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD40LG	CD70	ENSPPAP00000039865	ENSPPAP00000012314	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.787
CD40LG	FASLG	ENSPPAP00000039865	ENSPPAP00000010640	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Fas ligand; Belongs to the tumor necrosis factor family.	0.635
CD40LG	LTA	ENSPPAP00000039865	ENSPPAP00000032511	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Lymphotoxin alpha; Belongs to the tumor necrosis factor family.	0.696
CD40LG	LTB	ENSPPAP00000039865	ENSPPAP00000033459	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Lymphotoxin beta; Belongs to the tumor necrosis factor family.	0.670
CD40LG	TNF	ENSPPAP00000039865	ENSPPAP00000004174	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.804
CD40LG	TNFSF11	ENSPPAP00000039865	ENSPPAP00000023648	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Tumor necrosis factor ligand superfamily member.	0.546
CD40LG	TNFSF12	ENSPPAP00000039865	ENSPPAP00000028766	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	TNF superfamily member 12; Belongs to the tumor necrosis factor family.	0.693
CD40LG	TNFSF13B	ENSPPAP00000039865	ENSPPAP00000006211	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	TNF superfamily member 13b; Belongs to the tumor necrosis factor family.	0.846
CD40LG	TNFSF14	ENSPPAP00000039865	ENSPPAP00000028415	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	TNF superfamily member 14; Belongs to the tumor necrosis factor family.	0.633
CD40LG	TNFSF15	ENSPPAP00000039865	ENSPPAP00000009134	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	TNF superfamily member 15.	0.509
CD40LG	TNFSF4	ENSPPAP00000039865	ENSPPAP00000017916	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	TNF superfamily member 4; Belongs to the tumor necrosis factor family.	0.741
CD40LG	TNFSF8	ENSPPAP00000039865	ENSPPAP00000041068	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	TNF superfamily member 8; Belongs to the tumor necrosis factor family.	0.571
CD40LG	TNFSF9	ENSPPAP00000039865	ENSPPAP00000041654	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	TNF superfamily member 9; Belongs to the tumor necrosis factor family.	0.678
CD70	CD40LG	ENSPPAP00000012314	ENSPPAP00000039865	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.787
CD70	LTA	ENSPPAP00000012314	ENSPPAP00000032511	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	Lymphotoxin alpha; Belongs to the tumor necrosis factor family.	0.487
CD70	TNF	ENSPPAP00000012314	ENSPPAP00000004174	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.619
CD70	TNFSF12	ENSPPAP00000012314	ENSPPAP00000028766	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	TNF superfamily member 12; Belongs to the tumor necrosis factor family.	0.400
CD70	TNFSF14	ENSPPAP00000012314	ENSPPAP00000028415	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	TNF superfamily member 14; Belongs to the tumor necrosis factor family.	0.542
CD70	TNFSF15	ENSPPAP00000012314	ENSPPAP00000009134	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	TNF superfamily member 15.	0.481
CD70	TNFSF4	ENSPPAP00000012314	ENSPPAP00000017916	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	TNF superfamily member 4; Belongs to the tumor necrosis factor family.	0.682