(58 nodes) Ribosomal protein S5 domain 2-type fold network (Pan paniscus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	MVD	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (400 aa)
	ENSPPAP00000001096	Uncharacterized protein. (139 aa)
	ENSPPAP00000002133	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family. (246 aa)
	LOC100969109	Uncharacterized protein. (463 aa)
	ENSPPAP00000002542	Ribosomal_S5_C domain-containing protein. (79 aa)
	PMS1	PMS1 homolog 1, mismatch repair system component. (932 aa)
	PMS2	PMS1 homolog 2, mismatch repair system component. (771 aa)
	ENSPPAP00000003594	Ribosomal_S5_C domain-containing protein. (391 aa)
	ENSPPAP00000005886	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family. (253 aa)
	EXOSC5	Exosome component 5. (235 aa)
	PNPT1	Polyribonucleotide nucleotidyltransferase 1. (706 aa)
	ENSPPAP00000006339	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family. (184 aa)
	RPS16	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family. (165 aa)
	GALK1	Galactokinase 1. (422 aa)
	TRAP1	TNF receptor associated protein 1. (673 aa)
	ENSPPAP00000007277	Uncharacterized protein. (321 aa)
	EXOSC8	Exosome component 8. (276 aa)
	FCSK	Fucose kinase. (1084 aa)
	ENSPPAP00000010244	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family. (187 aa)
	RPS2	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family. (294 aa)
	LOC100978584	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family. (278 aa)
	ENSPPAP00000011449	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family. (314 aa)
	ENSPPAP00000012107	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family. (250 aa)
	EFTUD2	Elongation factor Tu GTP binding domain containing 2. (972 aa)
	LOC100980635	Uncharacterized protein. (361 aa)
	TOP2B	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1619 aa)
	LOC100992830	HATPase_c domain-containing protein. (584 aa)
	MLH1	MutL homolog 1. (756 aa)
	IMPACT	Impact RWD domain protein. (310 aa)
	LONP2	Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. (852 aa)
	HSP90AB1	HATPase_c domain-containing protein. (688 aa)
	GFM1	Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mito [...] (770 aa)
	ENSPPAP00000022240	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family. (217 aa)
	ENSPPAP00000023070	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family. (226 aa)
	LOC100977183	Uncharacterized protein. (448 aa)
	EXOSC4	Exosome component 4. (245 aa)
	LOC100994687	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family. (287 aa)
	GFM2	Ribosome-releasing factor 2, mitochondrial; Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (777 aa)
	MRPS9	Mitochondrial ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (396 aa)
	ENSPPAP00000029288	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family. (307 aa)
	LONP1	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...] (943 aa)
	HSP90B1	Heat shock protein 90 beta family member 1. (814 aa)
	GALK2	Galactokinase 2. (458 aa)
	HSP90AA1	HATPase_c domain-containing protein. (854 aa)
	LOC100991300	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family. (240 aa)
	ENSPPAP00000033303	HATPase_c domain-containing protein. (320 aa)
	EFL1	Elongation factor like GTPase 1. (1091 aa)
	ENSPPAP00000033816	HATPase_c domain-containing protein. (279 aa)
	MRPS5	Mitochondrial ribosomal protein S5; Belongs to the universal ribosomal protein uS5 family. (430 aa)
	ENSPPAP00000035415	Uncharacterized protein. (689 aa)
	LOC100984442	Ribosomal_S5_C domain-containing protein. (243 aa)
	MVK	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (396 aa)
	EEF2	Eukaryotic translation elongation factor 2. (861 aa)
	ENSPPAP00000040162	Uncharacterized protein. (169 aa)
	MLH3	MutL homolog 3. (1450 aa)
	EXOSC7	Exosome component 7. (291 aa)
	TOP2A	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1521 aa)
	EXOSC9	Exosome component 9. (456 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EEF2	ENSPPAP00000001096	ENSPPAP00000039391	ENSPPAP00000001096	Eukaryotic translation elongation factor 2.	Uncharacterized protein.	0.941
EEF2	ENSPPAP00000002133	ENSPPAP00000039391	ENSPPAP00000002133	Eukaryotic translation elongation factor 2.	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.	0.788
EEF2	ENSPPAP00000002542	ENSPPAP00000039391	ENSPPAP00000002542	Eukaryotic translation elongation factor 2.	Ribosomal_S5_C domain-containing protein.	0.788
EEF2	ENSPPAP00000003594	ENSPPAP00000039391	ENSPPAP00000003594	Eukaryotic translation elongation factor 2.	Ribosomal_S5_C domain-containing protein.	0.579
EEF2	ENSPPAP00000005886	ENSPPAP00000039391	ENSPPAP00000005886	Eukaryotic translation elongation factor 2.	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.	0.788
EEF2	ENSPPAP00000006339	ENSPPAP00000039391	ENSPPAP00000006339	Eukaryotic translation elongation factor 2.	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.	0.788
EEF2	ENSPPAP00000007277	ENSPPAP00000039391	ENSPPAP00000007277	Eukaryotic translation elongation factor 2.	Uncharacterized protein.	0.468
EEF2	ENSPPAP00000010244	ENSPPAP00000039391	ENSPPAP00000010244	Eukaryotic translation elongation factor 2.	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.	0.788
EEF2	ENSPPAP00000011449	ENSPPAP00000039391	ENSPPAP00000011449	Eukaryotic translation elongation factor 2.	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.	0.788
EEF2	ENSPPAP00000012107	ENSPPAP00000039391	ENSPPAP00000012107	Eukaryotic translation elongation factor 2.	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.	0.788
EEF2	ENSPPAP00000022240	ENSPPAP00000039391	ENSPPAP00000022240	Eukaryotic translation elongation factor 2.	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.	0.788
EEF2	ENSPPAP00000023070	ENSPPAP00000039391	ENSPPAP00000023070	Eukaryotic translation elongation factor 2.	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.	0.788
EEF2	ENSPPAP00000029288	ENSPPAP00000039391	ENSPPAP00000029288	Eukaryotic translation elongation factor 2.	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.	0.788
EEF2	ENSPPAP00000033303	ENSPPAP00000039391	ENSPPAP00000033303	Eukaryotic translation elongation factor 2.	HATPase_c domain-containing protein.	0.468
EEF2	ENSPPAP00000033816	ENSPPAP00000039391	ENSPPAP00000033816	Eukaryotic translation elongation factor 2.	HATPase_c domain-containing protein.	0.468
EEF2	ENSPPAP00000035415	ENSPPAP00000039391	ENSPPAP00000035415	Eukaryotic translation elongation factor 2.	Uncharacterized protein.	0.605
EEF2	ENSPPAP00000040162	ENSPPAP00000039391	ENSPPAP00000040162	Eukaryotic translation elongation factor 2.	Uncharacterized protein.	0.941
EEF2	GFM1	ENSPPAP00000039391	ENSPPAP00000021451	Eukaryotic translation elongation factor 2.	Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mito [...]	0.483
EEF2	HSP90AA1	ENSPPAP00000039391	ENSPPAP00000032623	Eukaryotic translation elongation factor 2.	HATPase_c domain-containing protein.	0.642
EEF2	HSP90AB1	ENSPPAP00000039391	ENSPPAP00000020014	Eukaryotic translation elongation factor 2.	HATPase_c domain-containing protein.	0.636