(25 nodes) Toll/interleukin-1 receptor homology (TIR) domain superfamily network (Pan paniscus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

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protein homology

Your Input:
	TICAM2	TIR domain-containing adaptor molecule 2. (235 aa)
	TIRAP	TIR domain-containing protein. (226 aa)
	TLR5	Toll-like receptor 5; Belongs to the Toll-like receptor family. (858 aa)
	IL1RAP	Interleukin 1 receptor accessory protein. (687 aa)
	TICAM1	RHIM domain-containing protein. (541 aa)
	IL17RD	Interleukin 17 receptor D. (738 aa)
	TLR10	TIR domain-containing protein; Belongs to the Toll-like receptor family. (811 aa)
	LOC100986336	TIR domain-containing protein. (1033 aa)
	TLR1	Toll-like receptor. (786 aa)
	TLR2	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
	TLR7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
	SIGIRR	Uncharacterized protein. (488 aa)
	IL18RAP	Interleukin 18 receptor accessory protein. (599 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
	IL1RL2	Interleukin 1 receptor like 2. (595 aa)
	TLR3	Toll-like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
	SARM1	Sterile alpha and TIR motif containing 1. (724 aa)
	IL18R1	Uncharacterized protein. (440 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
	BANK1	B cell scaffold protein with ankyrin repeats 1. (770 aa)
	IL1RAPL1	Interleukin 1 receptor accessory protein like 1. (696 aa)
	IL1R1	Interleukin 1 receptor type 1. (569 aa)
	TLR8	Toll-like receptor 8; Belongs to the Toll-like receptor family. (1041 aa)
	IL1RAPL2	Interleukin 1 receptor accessory protein like 2. (686 aa)
	PIK3AP1	Phosphoinositide-3-kinase adaptor protein 1. (805 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL18R1	IL18RAP	ENSPPAP00000025885	ENSPPAP00000012332	Uncharacterized protein.	Interleukin 18 receptor accessory protein.	0.999
IL18R1	IL1R1	ENSPPAP00000025885	ENSPPAP00000033001	Uncharacterized protein.	Interleukin 1 receptor type 1.	0.615
IL18R1	IL1RAP	ENSPPAP00000025885	ENSPPAP00000002050	Uncharacterized protein.	Interleukin 1 receptor accessory protein.	0.746
IL18R1	IL1RAPL2	ENSPPAP00000025885	ENSPPAP00000036313	Uncharacterized protein.	Interleukin 1 receptor accessory protein like 2.	0.413
IL18R1	IL1RL2	ENSPPAP00000025885	ENSPPAP00000016272	Uncharacterized protein.	Interleukin 1 receptor like 2.	0.547
IL18R1	MYD88	ENSPPAP00000025885	ENSPPAP00000029064	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.511
IL18R1	SIGIRR	ENSPPAP00000025885	ENSPPAP00000009875	Uncharacterized protein.	Uncharacterized protein.	0.558
IL18RAP	IL18R1	ENSPPAP00000012332	ENSPPAP00000025885	Interleukin 18 receptor accessory protein.	Uncharacterized protein.	0.999
IL18RAP	IL1R1	ENSPPAP00000012332	ENSPPAP00000033001	Interleukin 18 receptor accessory protein.	Interleukin 1 receptor type 1.	0.420
IL18RAP	IL1RAP	ENSPPAP00000012332	ENSPPAP00000002050	Interleukin 18 receptor accessory protein.	Interleukin 1 receptor accessory protein.	0.576
IL18RAP	IL1RL2	ENSPPAP00000012332	ENSPPAP00000016272	Interleukin 18 receptor accessory protein.	Interleukin 1 receptor like 2.	0.414
IL18RAP	MYD88	ENSPPAP00000012332	ENSPPAP00000029064	Interleukin 18 receptor accessory protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.504
IL18RAP	TLR10	ENSPPAP00000012332	ENSPPAP00000003305	Interleukin 18 receptor accessory protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.607
IL1R1	IL18R1	ENSPPAP00000033001	ENSPPAP00000025885	Interleukin 1 receptor type 1.	Uncharacterized protein.	0.615
IL1R1	IL18RAP	ENSPPAP00000033001	ENSPPAP00000012332	Interleukin 1 receptor type 1.	Interleukin 18 receptor accessory protein.	0.420
IL1R1	IL1RAP	ENSPPAP00000033001	ENSPPAP00000002050	Interleukin 1 receptor type 1.	Interleukin 1 receptor accessory protein.	0.995
IL1R1	IL1RL2	ENSPPAP00000033001	ENSPPAP00000016272	Interleukin 1 receptor type 1.	Interleukin 1 receptor like 2.	0.785
IL1R1	LOC100986336	ENSPPAP00000033001	ENSPPAP00000004282	Interleukin 1 receptor type 1.	TIR domain-containing protein.	0.616
IL1R1	MYD88	ENSPPAP00000033001	ENSPPAP00000029064	Interleukin 1 receptor type 1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.999
IL1R1	TICAM1	ENSPPAP00000033001	ENSPPAP00000002756	Interleukin 1 receptor type 1.	RHIM domain-containing protein.	0.489