(26 nodes) AAA ATPase, AAA+ lid domain network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (806 aa)
	NSF	N-ethylmaleimide sensitive factor, vesicle fusing ATPase. (744 aa)
	SPG7	SPG7 matrix AAA peptidase subunit, paraplegin. (795 aa)
	NVL	Nuclear VCP like. (848 aa)
	LOC100979126	Uncharacterized protein; Belongs to the AAA ATPase family. (462 aa)
	SPATA5L1	Spermatogenesis associated 5 like 1; Belongs to the AAA ATPase family. (669 aa)
	PSMC5	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
	KATNAL2	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. (538 aa)
	ENSPPAP00000007696	Uncharacterized protein; Belongs to the AAA ATPase family. (369 aa)
	PSMC2	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (432 aa)
	PSMC1	Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
	ATAD1	ATPase family AAA domain containing 1; Belongs to the AAA ATPase family. (363 aa)
	SPATA5	Spermatogenesis associated 5. (744 aa)
	ATAD2	ATPase family AAA domain containing 2. (1387 aa)
	KATNA1	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal p [...] (491 aa)
	PSMC3	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
	ENSPPAP00000038150	AAA_lid_3 domain-containing protein. (351 aa)
	PEX1	Peroxisomal biogenesis factor 1. (1283 aa)
	YME1L1	YME1 like 1 ATPase. (773 aa)
	ENSPPAP00000029830	AAA domain-containing protein. (395 aa)
	SPAST	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (602 aa)
	PSMC6	Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (411 aa)
	VPS4B	Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (446 aa)
	KATNAL1	Katanin p60 ATPase-containing subunit A-like 1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neur [...] (490 aa)
	AFG3L2	AFG3 like matrix AAA peptidase subunit 2. (797 aa)
	ATAD2B	ATPase family AAA domain containing 2B. (1458 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFG3L2	SPG7	ENSPPAP00000001458	ENSPPAP00000015347	AFG3 like matrix AAA peptidase subunit 2.	SPG7 matrix AAA peptidase subunit, paraplegin.	0.920
ATAD2	PSMC3	ENSPPAP00000040568	ENSPPAP00000039415	ATPase family AAA domain containing 2.	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family.	0.494
ATAD2	PSMC6	ENSPPAP00000040568	ENSPPAP00000021237	ATPase family AAA domain containing 2.	Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family.	0.494
ATAD2B	PSMC3	ENSPPAP00000020191	ENSPPAP00000039415	ATPase family AAA domain containing 2B.	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family.	0.494
ATAD2B	PSMC6	ENSPPAP00000020191	ENSPPAP00000021237	ATPase family AAA domain containing 2B.	Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family.	0.494
ENSPPAP00000007696	ENSPPAP00000038150	ENSPPAP00000007696	ENSPPAP00000038150	Uncharacterized protein; Belongs to the AAA ATPase family.	AAA_lid_3 domain-containing protein.	0.957
ENSPPAP00000007696	PSMC2	ENSPPAP00000007696	ENSPPAP00000008794	Uncharacterized protein; Belongs to the AAA ATPase family.	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family.	0.960
ENSPPAP00000007696	PSMC3	ENSPPAP00000007696	ENSPPAP00000039415	Uncharacterized protein; Belongs to the AAA ATPase family.	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family.	0.959
ENSPPAP00000007696	PSMC5	ENSPPAP00000007696	ENSPPAP00000042030	Uncharacterized protein; Belongs to the AAA ATPase family.	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family.	0.980
ENSPPAP00000007696	PSMC6	ENSPPAP00000007696	ENSPPAP00000021237	Uncharacterized protein; Belongs to the AAA ATPase family.	Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family.	0.974
ENSPPAP00000007696	SPATA5	ENSPPAP00000007696	ENSPPAP00000041585	Uncharacterized protein; Belongs to the AAA ATPase family.	Spermatogenesis associated 5.	0.481
ENSPPAP00000007696	SPATA5L1	ENSPPAP00000007696	ENSPPAP00000043222	Uncharacterized protein; Belongs to the AAA ATPase family.	Spermatogenesis associated 5 like 1; Belongs to the AAA ATPase family.	0.481
ENSPPAP00000007696	VCP	ENSPPAP00000007696	ENSPPAP00000035908	Uncharacterized protein; Belongs to the AAA ATPase family.	Valosin containing protein; Belongs to the AAA ATPase family.	0.522
ENSPPAP00000029830	ENSPPAP00000038150	ENSPPAP00000029830	ENSPPAP00000038150	AAA domain-containing protein.	AAA_lid_3 domain-containing protein.	0.957
ENSPPAP00000029830	PSMC2	ENSPPAP00000029830	ENSPPAP00000008794	AAA domain-containing protein.	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family.	0.958
ENSPPAP00000029830	PSMC3	ENSPPAP00000029830	ENSPPAP00000039415	AAA domain-containing protein.	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family.	0.958
ENSPPAP00000029830	PSMC5	ENSPPAP00000029830	ENSPPAP00000042030	AAA domain-containing protein.	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family.	0.979
ENSPPAP00000029830	PSMC6	ENSPPAP00000029830	ENSPPAP00000021237	AAA domain-containing protein.	Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family.	0.973
ENSPPAP00000029830	SPATA5	ENSPPAP00000029830	ENSPPAP00000041585	AAA domain-containing protein.	Spermatogenesis associated 5.	0.512
ENSPPAP00000029830	SPATA5L1	ENSPPAP00000029830	ENSPPAP00000043222	AAA domain-containing protein.	Spermatogenesis associated 5 like 1; Belongs to the AAA ATPase family.	0.514