(36 nodes) Sm domain network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPPAP00000018313	Uncharacterized protein. (120 aa)
	ENSPPAP00000021666	Small nuclear ribonucleoprotein-associated protein. (219 aa)
	LSM3	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (102 aa)
	SNRPF	Sm domain-containing protein. (127 aa)
	ENSPPAP00000026434	LsmAD domain-containing protein. (972 aa)
	SNRPB	Small nuclear ribonucleoprotein-associated protein. (231 aa)
	GEMIN6	Gem nuclear organelle associated protein 6. (167 aa)
	ENSPPAP00000027407	Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (78 aa)
	ENSPPAP00000028920	Sm domain-containing protein. (74 aa)
	ENSPPAP00000029044	Sm domain-containing protein. (78 aa)
	ENSPPAP00000029046	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (70 aa)
	LSM6	LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated. (80 aa)
	SNRPD2	Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (118 aa)
	ATXN2L	Ataxin 2 like. (1050 aa)
	SNRPD3	Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing. (126 aa)
	LOC100972230	Uncharacterized protein. (458 aa)
	EDC3	Enhancer of mRNA decapping 3. (508 aa)
	ENSPPAP00000036002	Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (67 aa)
	SNRPE	Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (92 aa)
	SNRPD1	Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. (119 aa)
	LSM14A	Uncharacterized protein. (477 aa)
	LSM8	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (75 aa)
	ENSPPAP00000041319	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (68 aa)
	ENSPPAP00000042775	Sm domain-containing protein. (81 aa)
	LSM4	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (238 aa)
	LSM5	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. (91 aa)
	LSM11	Sm domain-containing protein. (300 aa)
	LSM10	LSM10, U7 small nuclear RNA associated. (123 aa)
	GEMIN7	Gem nuclear organelle associated protein 7. (131 aa)
	NAA38	N(alpha)-acetyltransferase 38, NatC auxiliary subunit. (173 aa)
	LSM7	LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated. (103 aa)
	SNRPN	Small nuclear ribonucleoprotein-associated protein. (244 aa)
	ATXN2	Ataxin 2. (1248 aa)
	SNRPG	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (96 aa)
	LSM1	U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
	LSM2	U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATXN2	ATXN2L	ENSPPAP00000009761	ENSPPAP00000032580	Ataxin 2.	Ataxin 2 like.	0.924
ATXN2	EDC3	ENSPPAP00000009761	ENSPPAP00000034604	Ataxin 2.	Enhancer of mRNA decapping 3.	0.510
ATXN2	ENSPPAP00000021666	ENSPPAP00000009761	ENSPPAP00000021666	Ataxin 2.	Small nuclear ribonucleoprotein-associated protein.	0.505
ATXN2	NAA38	ENSPPAP00000009761	ENSPPAP00000007020	Ataxin 2.	N(alpha)-acetyltransferase 38, NatC auxiliary subunit.	0.440
ATXN2	SNRPN	ENSPPAP00000009761	ENSPPAP00000008842	Ataxin 2.	Small nuclear ribonucleoprotein-associated protein.	0.505
ATXN2L	ATXN2	ENSPPAP00000032580	ENSPPAP00000009761	Ataxin 2 like.	Ataxin 2.	0.924
ATXN2L	ENSPPAP00000021666	ENSPPAP00000032580	ENSPPAP00000021666	Ataxin 2 like.	Small nuclear ribonucleoprotein-associated protein.	0.505
ATXN2L	NAA38	ENSPPAP00000032580	ENSPPAP00000007020	Ataxin 2 like.	N(alpha)-acetyltransferase 38, NatC auxiliary subunit.	0.440
ATXN2L	SNRPN	ENSPPAP00000032580	ENSPPAP00000008842	Ataxin 2 like.	Small nuclear ribonucleoprotein-associated protein.	0.505
EDC3	ATXN2	ENSPPAP00000034604	ENSPPAP00000009761	Enhancer of mRNA decapping 3.	Ataxin 2.	0.510
EDC3	ENSPPAP00000042775	ENSPPAP00000034604	ENSPPAP00000042775	Enhancer of mRNA decapping 3.	Sm domain-containing protein.	0.739
EDC3	LOC100972230	ENSPPAP00000034604	ENSPPAP00000034078	Enhancer of mRNA decapping 3.	Uncharacterized protein.	0.816
EDC3	LSM1	ENSPPAP00000034604	ENSPPAP00000018300	Enhancer of mRNA decapping 3.	U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.	0.925
EDC3	LSM14A	ENSPPAP00000034604	ENSPPAP00000040141	Enhancer of mRNA decapping 3.	Uncharacterized protein.	0.816
EDC3	LSM2	ENSPPAP00000034604	ENSPPAP00000018560	Enhancer of mRNA decapping 3.	U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.739
EDC3	LSM3	ENSPPAP00000034604	ENSPPAP00000021762	Enhancer of mRNA decapping 3.	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.693
EDC3	LSM4	ENSPPAP00000034604	ENSPPAP00000043006	Enhancer of mRNA decapping 3.	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.881
EDC3	LSM5	ENSPPAP00000034604	ENSPPAP00000000917	Enhancer of mRNA decapping 3.	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.	0.698
EDC3	LSM6	ENSPPAP00000034604	ENSPPAP00000029823	Enhancer of mRNA decapping 3.	LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated.	0.648
EDC3	LSM7	ENSPPAP00000034604	ENSPPAP00000007313	Enhancer of mRNA decapping 3.	LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated.	0.717