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| | MAP3K20 | Mitogen-activated protein kinase kinase kinase 20. (803 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa) |
| | TIFA | Uncharacterized protein. (89 aa) |
| | TICAM2 | TIR domain-containing adaptor molecule 2. (235 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | NFKBIB | ANK_REP_REGION domain-containing protein. (270 aa) |
| | APP | Amyloid beta precursor protein. (770 aa) |
| | TICAM1 | RHIM domain-containing protein. (541 aa) |
| | ENSPPAP00000002958 | Uncharacterized protein. (231 aa) |
| | SKP1 | S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa) |
| | RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1250 aa) |
| | USP14 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (493 aa) |
| | PPP2R1A | Protein phosphatase 2 scaffold subunit Aalpha. (589 aa) |
| | NKIRAS2 | NFKB inhibitor interacting Ras like 2. (229 aa) |
| | NLRX1 | NLR family member X1. (975 aa) |
| | LOC100986336 | TIR domain-containing protein. (1033 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa) |
| | ALPK1 | Alpha kinase 1. (1246 aa) |
| | ENSPPAP00000004994 | TNF receptor-associated factor. (475 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | UBC | Uncharacterized protein. (153 aa) |
| | PPP4R4 | Protein phosphatase 4 regulatory subunit 4. (873 aa) |
| | ENSPPAP00000005251 | Uncharacterized protein. (204 aa) |
| | LOC100990877 | Ubiquitin-like domain-containing protein. (156 aa) |
| | UBE2V1-2 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (147 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (339 aa) |
| | FOSL2 | FOS like 2, AP-1 transcription factor subunit. (309 aa) |
| | PPP2R1B | Protein phosphatase 2 scaffold subunit Abeta. (660 aa) |
| | PPP4R1 | Protein phosphatase 4 regulatory subunit 1. (937 aa) |
| | LOC100992336 | WRNPLPNID domain-containing protein. (946 aa) |
| | PELI3 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa) |
| | ENSPPAP00000008828 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (133 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (508 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | TLR7 | Toll-like receptor 7; Belongs to the Toll-like receptor family. (1049 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (371 aa) |
| | ENSPPAP00000009924 | Ubiquitin-like domain-containing protein. (84 aa) |
| | LOC106634197 | Uncharacterized protein. (198 aa) |
| | UBE2N | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (148 aa) |
| | S100A12 | S100 calcium binding protein A12; Belongs to the S-100 family. (92 aa) |
| | LY96 | MD2 protein. (160 aa) |
| | AGER | Advanced glycosylation end-product specific receptor. (420 aa) |
| | NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (668 aa) |
| | DUSP6 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa) |
| | LRRC14 | Leucine rich repeat containing 14. (493 aa) |
| | MAPKAPK3 | MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa) |
| | LRRC45 | Leucine rich repeat containing 45. (670 aa) |
| | RPS6KA3 | Ribosomal protein S6 kinase. (740 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (294 aa) |
| | HMGB1 | Uncharacterized protein. (215 aa) |
| | IRF7 | Interferon regulatory factor 7. (516 aa) |
| | ENSPPAP00000014117 | Ubiquitin-like domain-containing protein. (145 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | NLRP6 | NLR family pyrin domain containing 6. (892 aa) |
| | TAB3 | TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa) |
| | NFKB2 | Nuclear factor kappa B subunit 2. (900 aa) |
| | CREB5 | Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (507 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (496 aa) |
| | S100B | S_100 domain-containing protein; Belongs to the S-100 family. (94 aa) |
| | SAA2 | Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (104 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa) |
| | FNBP4 | Formin binding protein 4. (1016 aa) |
| | LOC106635345 | Uncharacterized protein; Belongs to the SKP1 family. (164 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | ENSPPAP00000019542 | Ubiquitin-like domain-containing protein. (136 aa) |
| | LRRC71 | Leucine rich repeat containing 71. (559 aa) |
| | LRRC31 | Uncharacterized protein. (386 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (760 aa) |
| | TONSL | Tonsoku like, DNA repair protein. (1383 aa) |
| | BTRC | Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa) |
| | KHNYN | KH and NYN domain containing. (678 aa) |
| | RPS27A | Ribosomal protein S27a. (156 aa) |
| | N4BP1 | NEDD4 binding protein 1. (896 aa) |
| | NKIRAS1 | NFKB inhibitor interacting Ras like 1. (192 aa) |
| | MEF2A | Myocyte enhancer factor 2A. (505 aa) |
| | TNIP2 | CCHC NOA-type domain-containing protein. (322 aa) |
| | NLRC5 | NLR family CARD domain containing 5. (1865 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (275 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (325 aa) |
| | MAPKAPK2 | Protein kinase domain-containing protein. (365 aa) |
| | ATF7 | Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (494 aa) |
| | DUSP4 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa) |
| | SAA4 | Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (130 aa) |
| | CREM | cAMP responsive element modulator. (345 aa) |
| | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8. (467 aa) |
| | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1. (1372 aa) |
| | DUSP3 | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (162 aa) |
| | MAPK15 | Mitogen-activated protein kinase. (544 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (336 aa) |
| | ECSIT | ECSIT signalling integrator. (431 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa) |
| | LRRC74A | Leucine rich repeat containing 74A. (471 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (719 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (311 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase. (802 aa) |
| | ENSPPAP00000031014 | Protein kinase domain-containing protein. (371 aa) |
| | ATF1 | Activating transcription factor 1. (270 aa) |
| | IRAK2 | Interleukin 1 receptor associated kinase 2. (625 aa) |
| | RPS6KA2 | Ribosomal protein S6 kinase. (758 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (408 aa) |
| | SAA1 | Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa) |
| | ENSPPAP00000033137 | Uncharacterized protein. (187 aa) |
| | ENSPPAP00000033149 | Serine/threonine-protein phosphatase. (223 aa) |
| | MEF2C | Myocyte enhancer factor 2C. (482 aa) |
| | MAPK7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (816 aa) |
| | TLR8 | Toll-like receptor 8; Belongs to the Toll-like receptor family. (1041 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (712 aa) |
| | PELI2 | Pellino E3 ubiquitin protein ligase family member 2. (394 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (776 aa) |
| | ENSPPAP00000035541 | CCHC NOA-type domain-containing protein. (372 aa) |
| | RPS6KA1 | Ribosomal protein S6 kinase. (744 aa) |
| | FBXW11 | F-box and WD repeat domain containing 11. (563 aa) |
| | NLRP13 | NLR family pyrin domain containing 13. (1036 aa) |
| | CD14 | CD14 molecule. (384 aa) |
| | LRRC74B | Leucine rich repeat containing 74B. (392 aa) |
| | LRRC34 | Leucine rich repeat containing 34. (464 aa) |
| | NFKBIA | ANK_REP_REGION domain-containing protein. (456 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | ENSPPAP00000039346 | CULLIN_2 domain-containing protein; Belongs to the cullin family. (627 aa) |
| | NLRP9 | NLR family pyrin domain containing 9. (991 aa) |
| | KXD1 | Ubiquitin-like domain-containing protein. (231 aa) |
| | LOC100987671 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (88 aa) |
| | CREB1 | cAMP responsive element binding protein 1. (341 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1040 aa) |
| | ENSPPAP00000040700 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (140 aa) |
| | ELK1 | ETS transcription factor ELK1. (428 aa) |
| | VWC2 | Von Willebrand factor C domain containing 2. (325 aa) |
| | ENSPPAP00000042214 | Protein kinase domain-containing protein. (328 aa) |
| | DUSP7 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (368 aa) |
| | VRK3 | VRK serine/threonine kinase 3. (474 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa) |
| | PELI1 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa) |
