33 items (Pan paniscus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SKI	SKI proto-oncogene. (666 aa)
	SMAD7	MH2 domain-containing protein. (211 aa)
	SKIL	SKI like proto-oncogene. (684 aa)
	ENSPPAP00000012742	Homeobox domain-containing protein. (255 aa)
	NEDD4L	NEDD4 like E3 ubiquitin protein ligase. (1080 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	LOC100986655	GPS2_interact domain-containing protein. (211 aa)
	MAPK1	Mitogen-activated protein kinase. (339 aa)
	LOC100992554	Nuclear receptor corepressor 1. (2259 aa)
	LOC100990877	Ubiquitin-like domain-containing protein. (156 aa)
	RNF111	Ring finger protein 111. (993 aa)
	ENSPPAP00000005386	C2 domain-containing protein. (54 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (311 aa)
	ENSPPAP00000042767	SKIP_SNW domain-containing protein. (390 aa)
	SMURF2	E3 ubiquitin-protein ligase. (790 aa)
	KXD1	Ubiquitin-like domain-containing protein. (231 aa)
	SNW1	SNW domain containing 1. (571 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
	NCOR2	Nuclear receptor corepressor 2. (2510 aa)
	ATP1B4	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (357 aa)
	STAT1	Signal transducer and activator of transcription. (759 aa)
	USP9X	Ubiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2576 aa)
	WWTR1	WW domain containing transcription regulator 1. (400 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	TGIF1	TGFB induced factor homeobox 1. (401 aa)
	TGIF2	TGFB induced factor homeobox 2. (237 aa)
	RPS27A	Ribosomal protein S27a. (156 aa)
	ENSPPAP00000024044	PPM-type phosphatase domain-containing protein. (75 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	PPM1A	Protein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
	TRIM33	Tripartite motif containing 33. (1083 aa)
	UBE2D1	Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP1B4	ENSPPAP00000042767	ENSPPAP00000034573	ENSPPAP00000042767	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	SKIP_SNW domain-containing protein.	0.895
ATP1B4	MAPK1	ENSPPAP00000034573	ENSPPAP00000006243	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Mitogen-activated protein kinase.	0.900
ATP1B4	SMAD7	ENSPPAP00000034573	ENSPPAP00000016382	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	MH2 domain-containing protein.	0.596
ATP1B4	SNW1	ENSPPAP00000034573	ENSPPAP00000036281	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	SNW domain containing 1.	0.895
ENSPPAP00000005386	KXD1	ENSPPAP00000005386	ENSPPAP00000040077	C2 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.808
ENSPPAP00000005386	LOC100990877	ENSPPAP00000005386	ENSPPAP00000005800	C2 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.737
ENSPPAP00000005386	RPS27A	ENSPPAP00000005386	ENSPPAP00000023056	C2 domain-containing protein.	Ribosomal protein S27a.	0.737
ENSPPAP00000005386	SMAD2	ENSPPAP00000005386	ENSPPAP00000024577	C2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.828
ENSPPAP00000005386	SMAD3	ENSPPAP00000005386	ENSPPAP00000021162	C2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.800
ENSPPAP00000005386	SMAD4	ENSPPAP00000005386	ENSPPAP00000009478	C2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.749
ENSPPAP00000005386	SMAD7	ENSPPAP00000005386	ENSPPAP00000016382	C2 domain-containing protein.	MH2 domain-containing protein.	0.909
ENSPPAP00000005386	UBE2D1	ENSPPAP00000005386	ENSPPAP00000027707	C2 domain-containing protein.	Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family.	0.450
ENSPPAP00000012742	HDAC1	ENSPPAP00000012742	ENSPPAP00000018577	Homeobox domain-containing protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.500
ENSPPAP00000012742	SMAD2	ENSPPAP00000012742	ENSPPAP00000024577	Homeobox domain-containing protein.	Mothers against decapentaplegic homolog.	0.581
ENSPPAP00000012742	SMAD3	ENSPPAP00000012742	ENSPPAP00000021162	Homeobox domain-containing protein.	Mothers against decapentaplegic homolog.	0.518
ENSPPAP00000012742	SMAD4	ENSPPAP00000012742	ENSPPAP00000009478	Homeobox domain-containing protein.	Mothers against decapentaplegic homolog.	0.493
ENSPPAP00000024044	SMAD2	ENSPPAP00000024044	ENSPPAP00000024577	PPM-type phosphatase domain-containing protein.	Mothers against decapentaplegic homolog.	0.728
ENSPPAP00000024044	SMAD3	ENSPPAP00000024044	ENSPPAP00000021162	PPM-type phosphatase domain-containing protein.	Mothers against decapentaplegic homolog.	0.717
ENSPPAP00000024044	SMAD4	ENSPPAP00000024044	ENSPPAP00000009478	PPM-type phosphatase domain-containing protein.	Mothers against decapentaplegic homolog.	0.572
ENSPPAP00000024044	SMAD7	ENSPPAP00000024044	ENSPPAP00000016382	PPM-type phosphatase domain-containing protein.	MH2 domain-containing protein.	0.426