STRINGSTRING
RBP2 RBP2 RBP4 RBP4 ENSPPAP00000037502 ENSPPAP00000037502 FNTA FNTA RDH10 RDH10 HSPG2 HSPG2 RHO RHO BCO2 BCO2 LRP8 LRP8 OPN1SW OPN1SW ENSPPAP00000034823 ENSPPAP00000034823 METAP2 METAP2 LRP12 LRP12 GNB5 GNB5 GUCA1A GUCA1A GUCY2D GUCY2D NMT1 NMT1 AWAT2 AWAT2 PDE6A PDE6A GNB1 GNB1 PDE6H PDE6H PDE6B PDE6B GPC6 GPC6 DEPDC1 DEPDC1 SDC1 SDC1 CALM3 CALM3 METAP1 METAP1 GRK7 GRK7 CNGB1 CNGB1 APOA4 APOA4 PLEKHD1 PLEKHD1 RDH11 RDH11 APOA2 APOA2 LRP3 LRP3 GPC1 GPC1 ENSPPAP00000027118 ENSPPAP00000027118 GPC4 GPC4 STRA6 STRA6 ABCA4 ABCA4 NAPEPLD NAPEPLD LOC103783188 LOC103783188 MYO7A MYO7A LOC100984876 LOC100984876 PYROXD2 PYROXD2 APOE APOE GNAT1 GNAT1 SDC2 SDC2 GPIHBP1 GPIHBP1 GUCA1C GUCA1C RDH8 RDH8 APOM APOM AKR1C1 AKR1C1 VEZT VEZT AKR1C4 AKR1C4 AKR1B10 AKR1B10 ENSPPAP00000018003 ENSPPAP00000018003 SDC3 SDC3 FNTB FNTB PRKCA PRKCA RETSAT RETSAT LRAT LRAT AGRN AGRN RCVRN RCVRN NMT2 NMT2 MYO7B MYO7B CAMKMT CAMKMT DHRS12 DHRS12 GRK4 GRK4 PPEF2 PPEF2 LRP1 LRP1 RGS9 RGS9 LRP10 LRP10 RLBP1 RLBP1 HSD17B6 HSD17B6 PDE6G PDE6G GPC5 GPC5 PRKCQ PRKCQ GUCA1B GUCA1B AKR1C3 AKR1C3 PPEF1 PPEF1 RBP1 RBP1 GNGT1 GNGT1 PLB1 PLB1 LDLR LDLR CYP4V2 CYP4V2 APOA1 APOA1 CLPS CLPS PDE6C PDE6C SDC4 SDC4 LOC100988315 LOC100988315 LPL LPL CNGA1 CNGA1 APOC3 APOC3 SAG SAG RBP3 RBP3 GPC3 GPC3 RDH5 RDH5 PTCHD1 PTCHD1 BCO1 BCO1 RGS9BP RGS9BP SMPDL3A SMPDL3A APOB APOB GRK1 GRK1 CNGB3 CNGB3 RDH16 RDH16 SDR9C7 SDR9C7 GPC2 GPC2 LRP1B LRP1B TTR TTR DHRS9 DHRS9 DHRS3 DHRS3 CHURC1 CHURC1 GUCY2F GUCY2F SLC24A1 SLC24A1 RPE65 RPE65 PTCHD4 PTCHD4 APOC2 APOC2 PTCHD3 PTCHD3 HSD17B1 HSD17B1 LRP2 LRP2 RDH12 RDH12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RBP2Retinol binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (134 aa)
RBP4Retinol-binding protein; Retinol-binding protein that mediates retinol transport in blood plasma. (201 aa)
ENSPPAP00000037502DEP domain-containing protein. (737 aa)
FNTAFarnesyltransferase, CAAX box, alpha. (332 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
HSPG2Heparan sulfate proteoglycan 2. (4369 aa)
RHORhodopsin. (348 aa)
BCO2Beta-carotene oxygenase 2. (579 aa)
LRP8LDL receptor related protein 8. (927 aa)
OPN1SWShort-wave-sensitive opsin 1; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal (By similarity). Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of functioning cone photoreceptors (By similarity). Involved in ensuring correct abundance and localization of retinal membrane proteins (By similarity). May increase spectral sensitivity in dim light (By similarity). (348 aa)
ENSPPAP00000034823Uncharacterized protein. (342 aa)
METAP2Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily. (477 aa)
LRP12LDL receptor related protein 12. (845 aa)
GNB5G protein subunit beta 5. (395 aa)
GUCA1AUncharacterized protein. (207 aa)
GUCY2DGuanylate cyclase. (981 aa)
NMT1Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (496 aa)
AWAT2Acyl-CoA wax alcohol acyltransferase 2. (333 aa)
PDE6APhosphodiesterase. (951 aa)
GNB1G protein subunit beta 1. (340 aa)
PDE6HPhosphodiesterase 6H. (83 aa)
PDE6BPhosphodiesterase. (805 aa)
GPC6Glypican 6; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (501 aa)
DEPDC1DEP domain containing 1. (812 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (334 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
METAP1Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). (348 aa)
GRK7G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (553 aa)
CNGB1Cyclic nucleotide gated channel subunit beta 1. (1231 aa)
APOA4Apolipoprotein A4. (396 aa)
PLEKHD1Pleckstrin homology and coiled-coil domain containing D1. (506 aa)
RDH11Retinol dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (318 aa)
APOA2Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family. (133 aa)
LRP3LDL receptor related protein 3. (774 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (636 aa)
ENSPPAP00000027118Uncharacterized protein. (125 aa)
GPC4Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (556 aa)
STRA6Stimulated by retinoic acid 6. (706 aa)
ABCA4ATP binding cassette subfamily A member 4. (2159 aa)
NAPEPLDN-acyl phosphatidylethanolamine phospholipase D. (393 aa)
LOC103783188Aldo_ket_red domain-containing protein. (205 aa)
MYO7AMyosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2222 aa)
LOC100984876Uncharacterized protein. (372 aa)
PYROXD2Pyridine nucleotide-disulphide oxidoreductase domain 2. (581 aa)
APOEApolipoprotein E. (317 aa)
GNAT1G protein subunit alpha transducin 1. (350 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
GPIHBP1Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1. (184 aa)
GUCA1CGuanylate cyclase activator 1C. (209 aa)
RDH8Retinol dehydrogenase 8; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (329 aa)
APOMApolipoprotein M. (188 aa)
AKR1C1Aldo-keto reductase family 1 member C1. (295 aa)
VEZTVezatin, adherens junctions transmembrane protein. (779 aa)
AKR1C4Aldo-keto reductase family 1 member C4. (323 aa)
AKR1B10Aldo-keto reductase family 1 member B10. (307 aa)
ENSPPAP00000018003Uncharacterized protein. (3229 aa)
SDC3Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (396 aa)
FNTBProtein farnesyltransferase subunit beta; Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. (437 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
RETSATRetinol saturase. (610 aa)
LRATLecithin retinol acyltransferase. (230 aa)
AGRNAgrin. (1816 aa)
RCVRNRecoverin. (200 aa)
NMT2Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (497 aa)
MYO7BMyosin VIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2116 aa)
CAMKMTCalmodulin-lysine N-methyltransferase. (323 aa)
DHRS12Dehydrogenase/reductase 12. (328 aa)
GRK4G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (577 aa)
PPEF2Serine/threonine-protein phosphatase with EF-hands. (753 aa)
LRP1LDL receptor related protein 1. (4544 aa)
RGS9Regulator of G protein signaling 9. (674 aa)
LRP10LDL receptor related protein 10. (715 aa)
RLBP1Retinaldehyde binding protein 1. (317 aa)
HSD17B6Hydroxysteroid 17-beta dehydrogenase 6; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
PDE6GUncharacterized protein. (137 aa)
GPC5Glypican 5; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (572 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (758 aa)
GUCA1BGuanylate cyclase activator 1B. (200 aa)
AKR1C3Aldo-keto reductase family 1 member C3. (323 aa)
PPEF1Serine/threonine-protein phosphatase with EF-hands. (653 aa)
RBP1Retinol binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (197 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PLB1Phospholipase B1. (1459 aa)
LDLRLow density lipoprotein receptor. (849 aa)
CYP4V2Cytochrome P450 family 4 subfamily V member 2; Belongs to the cytochrome P450 family. (525 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family. (267 aa)
CLPSColipase. (112 aa)
PDE6CPhosphodiesterase. (858 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (199 aa)
LOC100988315Aldo_ket_red domain-containing protein. (303 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (475 aa)
CNGA1Cyclic nucleotide gated channel subunit alpha 1. (759 aa)
APOC3Apolipoprotein C3. (99 aa)
SAGS-antigen visual arrestin. (389 aa)
RBP3Retinol binding protein 3. (1247 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (603 aa)
RDH5Retinol dehydrogenase 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (318 aa)
PTCHD1Patched domain containing 1. (888 aa)
BCO1Beta-carotene oxygenase 1. (547 aa)
RGS9BPRegulator of G protein signaling 9 binding protein. (235 aa)
SMPDL3AAcid sphingomyelinase-like phosphodiesterase. (453 aa)
APOBApolipoprotein B. (4535 aa)
GRK1G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (563 aa)
CNGB3Cyclic nucleotide gated channel subunit beta 3. (802 aa)
RDH16Retinol dehydrogenase 16; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
SDR9C7Short chain dehydrogenase/reductase family 9C member 7; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (313 aa)
GPC2Glypican 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (508 aa)
LRP1BLDL receptor related protein 1B. (4322 aa)
TTRTransthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. (147 aa)
DHRS9Dehydrogenase/reductase 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (338 aa)
DHRS3Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
CHURC1Churchill domain containing 1. (140 aa)
GUCY2FGuanylate cyclase. (1108 aa)
SLC24A1Solute carrier family 24 member 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1094 aa)
RPE65Retinoid isomerohydrolase RPE65. (533 aa)
PTCHD4Patched domain containing 4. (843 aa)
APOC2Uncharacterized protein. (178 aa)
PTCHD3SSD domain-containing protein. (455 aa)
HSD17B1Hydroxysteroid 17-beta dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (351 aa)
LRP2LDL receptor related protein 2. (4641 aa)
RDH12Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (316 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
Server load: low (16%) [HD]