STRINGSTRING
PAN2 PAN2 ENSPPAP00000000712 ENSPPAP00000000712 CNOT3 CNOT3 LSM5 LSM5 PATL2 PATL2 XRN1 XRN1 EIF4A2 EIF4A2 DIS3L DIS3L ENSPPAP00000005060 ENSPPAP00000005060 TMC7 TMC7 CNOT1 CNOT1 EXOSC5 EXOSC5 LSM7 LSM7 PNLDC1 PNLDC1 ENSPPAP00000007417 ENSPPAP00000007417 CNOT10 CNOT10 EXOSC8 EXOSC8 ENSPPAP00000008238 ENSPPAP00000008238 PAN3 PAN3 ENSPPAP00000009956 ENSPPAP00000009956 ENSPPAP00000012058 ENSPPAP00000012058 ENSPPAP00000012261 ENSPPAP00000012261 EIF4B EIF4B TMC4 TMC4 EXOSC3 EXOSC3 HBS1L HBS1L ENSPPAP00000013881 ENSPPAP00000013881 CNOT6L CNOT6L LOC100977376 LOC100977376 PARN PARN C19orf54 C19orf54 DCP1B DCP1B DCPS DCPS DIS3L2 DIS3L2 CNOT6 CNOT6 LSM1 LSM1 LSM2 LSM2 EDC4 EDC4 TTC37 TTC37 CNOT11 CNOT11 ENSPPAP00000020415 ENSPPAP00000020415 ENSPPAP00000020924 ENSPPAP00000020924 LSM3 LSM3 ENSPPAP00000022078 ENSPPAP00000022078 PATL1 PATL1 EXOSC2 EXOSC2 DDX6 DDX6 LOC100975612 LOC100975612 ENSPPAP00000024279 ENSPPAP00000024279 ENSPPAP00000025082 ENSPPAP00000025082 EXOSC4 EXOSC4 TENT2 TENT2 NT5C3B NT5C3B ENSPPAP00000026880 ENSPPAP00000026880 EIF4E1B EIF4E1B WDR61 WDR61 LOC100992462 LOC100992462 PAIP1 PAIP1 CNOT7 CNOT7 TUT1 TUT1 CNOT9 CNOT9 HIGD1B HIGD1B LRRC27 LRRC27 PABPC1 PABPC1 TUT4 TUT4 LSM6 LSM6 LOC100984823 LOC100984823 ENSPPAP00000030504 ENSPPAP00000030504 ENSPPAP00000031085 ENSPPAP00000031085 TUT7 TUT7 MTPAP MTPAP ENSPPAP00000032383 ENSPPAP00000032383 ENSPPAP00000032433 ENSPPAP00000032433 KIFBP KIFBP TNKS1BP1 TNKS1BP1 PABPC1L PABPC1L EXOSC1 EXOSC1 EIF4A1 EIF4A1 ENSPPAP00000034250 ENSPPAP00000034250 EDC3 EDC3 SKIV2L SKIV2L ENSPPAP00000035130 ENSPPAP00000035130 ENSPPAP00000035856 ENSPPAP00000035856 ENSPPAP00000036194 ENSPPAP00000036194 ENSPPAP00000036339 ENSPPAP00000036339 DIS3 DIS3 CNOT4 CNOT4 DCP2 DCP2 ENSPPAP00000039067 ENSPPAP00000039067 CNOT2 CNOT2 EIF4G1 EIF4G1 ENSPPAP00000040806 ENSPPAP00000040806 DCP1A DCP1A TOE1 TOE1 EXOSC7 EXOSC7 PABPC4 PABPC4 EIF4E EIF4E CNOT8 CNOT8 PABPC4L PABPC4L EXOSC9 EXOSC9 ENSPPAP00000042775 ENSPPAP00000042775 LSM4 LSM4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAN2PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1198 aa)
ENSPPAP00000000712Q_MOTIF domain-containing protein. (88 aa)
CNOT3CCR4-NOT transcription complex subunit 3. (753 aa)
LSM5U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. (91 aa)
PATL2PAT1 homolog 2. (545 aa)
XRN15'-3' exoribonuclease 1. (1706 aa)
EIF4A2Eukaryotic translation initiation factor 4A2; Belongs to the DEAD box helicase family. (407 aa)
DIS3LDIS3 like exosome 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (1058 aa)
ENSPPAP00000005060Uncharacterized protein; Belongs to the DEAD box helicase family. (371 aa)
TMC7Transmembrane channel-like protein. (715 aa)
CNOT1CCR4-NOT transcription complex subunit 1. (2383 aa)
EXOSC5Exosome component 5. (235 aa)
LSM7LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated. (103 aa)
PNLDC1PARN like, ribonuclease domain containing 1. (531 aa)
ENSPPAP00000007417Uncharacterized protein. (526 aa)
CNOT10CCR4-NOT transcription complex subunit 10. (804 aa)
EXOSC8Exosome component 8. (276 aa)
ENSPPAP00000008238Uncharacterized protein; Belongs to the DEAD box helicase family. (349 aa)
PAN3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (743 aa)
ENSPPAP00000009956Uncharacterized protein. (245 aa)
ENSPPAP00000012058RRM domain-containing protein. (248 aa)
ENSPPAP00000012261Uncharacterized protein. (663 aa)
EIF4BRRM domain-containing protein. (501 aa)
TMC4Transmembrane channel-like protein. (706 aa)
EXOSC3Exosome component 3. (275 aa)
HBS1LHBS1 like translational GTPase. (698 aa)
ENSPPAP00000013881RRM domain-containing protein. (505 aa)
CNOT6LCCR4-NOT transcription complex subunit 6 like. (548 aa)
LOC100977376RRM domain-containing protein. (407 aa)
PARNPoly(A)-specific ribonuclease. (639 aa)
C19orf54Chromosome 19 open reading frame 54. (351 aa)
DCP1BDecapping mRNA 1B. (621 aa)
DCPSDecapping enzyme, scavenger. (337 aa)
DIS3L2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (889 aa)
CNOT6CCR4-NOT transcription complex subunit 6. (557 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
LSM2U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa)
EDC4Enhancer of mRNA decapping 4. (1401 aa)
TTC37Tetratricopeptide repeat domain 37. (1552 aa)
CNOT11CCR4-NOT transcription complex subunit 11. (434 aa)
ENSPPAP00000020415Uncharacterized protein. (92 aa)
ENSPPAP00000020924Uncharacterized protein. (353 aa)
LSM3U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (102 aa)
ENSPPAP00000022078Endo/exonuclease/phosphatase domain-containing protein. (470 aa)
PATL1PAT1 homolog 1, processing body mRNA decay factor. (770 aa)
EXOSC2Exosome component 2. (293 aa)
DDX6DEAD-box helicase 6; Belongs to the DEAD box helicase family. (483 aa)
LOC100975612Uncharacterized protein; Belongs to the DEAD box helicase family. (371 aa)
ENSPPAP00000024279Helicase ATP-binding domain-containing protein. (193 aa)
ENSPPAP00000025082Uncharacterized protein. (71 aa)
EXOSC4Exosome component 4. (245 aa)
TENT2Terminal nucleotidyltransferase 2. (484 aa)
NT5C3B5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (300 aa)
ENSPPAP00000026880Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (222 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (249 aa)
WDR61WD repeat domain 61. (305 aa)
LOC100992462Uncharacterized protein. (519 aa)
PAIP1Poly(A) binding protein interacting protein 1. (479 aa)
CNOT7CCR4-NOT transcription complex subunit 7. (285 aa)
TUT1RRM domain-containing protein. (912 aa)
CNOT9CCR4-NOT transcription complex subunit 9. (331 aa)
HIGD1BHIG1 hypoxia inducible domain family member 1B. (99 aa)
LRRC27Leucine rich repeat containing 27. (530 aa)
PABPC1Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (645 aa)
TUT4Terminal uridylyl transferase 4. (1659 aa)
LSM6LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated. (80 aa)
LOC100984823Uncharacterized protein. (543 aa)
ENSPPAP00000030504RRM domain-containing protein. (542 aa)
ENSPPAP00000031085Uncharacterized protein. (277 aa)
TUT7Terminal uridylyl transferase 7. (1540 aa)
MTPAPMitochondrial poly(A) polymerase. (582 aa)
ENSPPAP00000032383Uncharacterized protein; Belongs to the DEAD box helicase family. (368 aa)
ENSPPAP00000032433Uncharacterized protein. (64 aa)
KIFBPKIF1 binding protein. (646 aa)
TNKS1BP1Tankyrase 1 binding protein 1. (1727 aa)
PABPC1LPolyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (614 aa)
EXOSC1Exosome component 1. (197 aa)
EIF4A1Eukaryotic translation initiation factor 4A1; Belongs to the DEAD box helicase family. (406 aa)
ENSPPAP00000034250Uncharacterized protein; Belongs to the DEAD box helicase family. (413 aa)
EDC3Enhancer of mRNA decapping 3. (508 aa)
SKIV2LSki2 like RNA helicase. (1245 aa)
ENSPPAP00000035130Uncharacterized protein. (433 aa)
ENSPPAP00000035856Q_MOTIF domain-containing protein. (96 aa)
ENSPPAP00000036194Uncharacterized protein. (284 aa)
ENSPPAP00000036339Uncharacterized protein. (244 aa)
DIS3DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (958 aa)
CNOT4CCR4-NOT transcription complex subunit 4. (712 aa)
DCP2Decapping mRNA 2. (417 aa)
ENSPPAP00000039067Uncharacterized protein. (341 aa)
CNOT2CCR4-NOT transcription complex subunit 2. (550 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1606 aa)
ENSPPAP00000040806RRM domain-containing protein. (352 aa)
DCP1ADecapping mRNA 1A. (582 aa)
TOE1Target of EGR1, exonuclease. (523 aa)
EXOSC7Exosome component 7. (291 aa)
PABPC4Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (660 aa)
EIF4EUncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (246 aa)
CNOT8CCR4-NOT transcription complex subunit 8. (292 aa)
PABPC4LPoly(A) binding protein cytoplasmic 4 like. (352 aa)
EXOSC9Exosome component 9. (456 aa)
ENSPPAP00000042775Sm domain-containing protein. (81 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (238 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.