STRINGSTRING
COX1 COX1 COX2 COX2 COX3 COX3 LOC106634335 LOC106634335 LOC100991232 LOC100991232 PRDX1 PRDX1 ENSPPAP00000000554 ENSPPAP00000000554 ENSPPAP00000000738 ENSPPAP00000000738 GPX2 GPX2 COX5A COX5A ENSPPAP00000039831 ENSPPAP00000039831 ENSPPAP00000039777 ENSPPAP00000039777 COX18 COX18 TXN TXN RPTOR RPTOR COX6C COX6C SESN1 SESN1 ENSPPAP00000037963 ENSPPAP00000037963 COX5B COX5B H6PD H6PD NME9 NME9 PRKAG1 PRKAG1 LRPPRC LRPPRC LAMTOR1 LAMTOR1 COX11 COX11 COX4I2 COX4I2 COX4I1 COX4I1 AKT1 AKT1 GPI GPI ENSPPAP00000034038 ENSPPAP00000034038 COX6B1 COX6B1 ENSPPAP00000033668 ENSPPAP00000033668 LOC100995377 LOC100995377 ENSPPAP00000032795 ENSPPAP00000032795 TXNRD3 TXNRD3 YWHAZ YWHAZ LOC100978515 LOC100978515 COX7B COX7B COX16 COX16 AGO2 AGO2 LAMTOR4 LAMTOR4 TP63 TP63 LAMTOR2 LAMTOR2 ENSPPAP00000028807 ENSPPAP00000028807 SESN2 SESN2 YWHAB YWHAB MTOR MTOR COX19 COX19 ENSPPAP00000026327 ENSPPAP00000026327 SCO1 SCO1 DESI2 DESI2 PRKAB2 PRKAB2 PRKAA1 PRKAA1 ENSPPAP00000025509 ENSPPAP00000025509 AKT3 AKT3 ENSPPAP00000024731 ENSPPAP00000024731 TSC1 TSC1 LOC100982423 LOC100982423 CRYBB3 CRYBB3 YWHAH YWHAH GSR GSR C1orf198 C1orf198 DESI1 DESI1 AGO1 AGO1 TACO1 TACO1 RRAGB RRAGB LAMTOR3 LAMTOR3 PRDX2 PRDX2 RHEBL1 RHEBL1 TSC2 TSC2 COX7C COX7C COX7A2L COX7A2L PRKAB1 PRKAB1 MLST8 MLST8 COX20 COX20 ENSPPAP00000019421 ENSPPAP00000019421 ENSPPAP00000019251 ENSPPAP00000019251 ENSPPAP00000018449 ENSPPAP00000018449 SLC38A9 SLC38A9 AGO3 AGO3 TXNRD1 TXNRD1 TXNDC11 TXNDC11 LOC100974009 LOC100974009 AGO4 AGO4 PRDX5 PRDX5 MOV10 MOV10 LOC100984401 LOC100984401 NME8 NME8 LOC100983479 LOC100983479 COX6A2 COX6A2 YWHAE YWHAE G6PD G6PD RRM2B RRM2B PRKAG2 PRKAG2 RRAGC RRAGC RRAGD RRAGD ENSPPAP00000013152 ENSPPAP00000013152 PTEN PTEN GATC GATC ENSPPAP00000011923 ENSPPAP00000011923 TIGAR TIGAR COX5A-2 COX5A-2 TP53 TP53 AKT2 AKT2 PRKAG3 PRKAG3 TNRC6B TNRC6B SURF1 SURF1 COX8A COX8A GLS2 GLS2 ENSPPAP00000009855 ENSPPAP00000009855 RHEB RHEB SESN3 SESN3 DDIT4 DDIT4 DDIT4L DDIT4L LOC103785895 LOC103785895 COX6B2 COX6B2 GLS GLS TRIR TRIR CRYGN CRYGN COX7B2 COX7B2 CYCS CYCS ENSPPAP00000003283 ENSPPAP00000003283 SFN SFN RRAGA RRAGA NPVF NPVF SCO2 SCO2 COX7A2 COX7A2 ENSPPAP00000043225 ENSPPAP00000043225 PRKAA2 PRKAA2 TXNDC8 TXNDC8 COX7A1 COX7A1 ENSPPAP00000041551 ENSPPAP00000041551 LAMTOR5 LAMTOR5 YWHAQ YWHAQ KIAA1671 KIAA1671 COX6A1 COX6A1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
COX1Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (513 aa)
COX2Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (227 aa)
COX3Cytochrome c oxidase subunit 3; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (261 aa)
LOC106634335Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC10099123214_3_3 domain-containing protein. (74 aa)
PRDX1Peroxiredoxin 1. (199 aa)
ENSPPAP00000000554Uncharacterized protein. (93 aa)
ENSPPAP00000000738Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
GPX2Glutathione peroxidase; Belongs to the glutathione peroxidase family. (150 aa)
COX5AUncharacterized protein. (139 aa)
ENSPPAP0000003983114_3_3 domain-containing protein; Belongs to the 14-3-3 family. (210 aa)
ENSPPAP00000039777Thioredoxin domain-containing protein. (93 aa)
COX18Cytochrome c oxidase assembly factor COX18. (334 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
COX6CCytochrome c oxidase subunit 6C. (75 aa)
SESN1Sestrin 1. (551 aa)
ENSPPAP00000037963Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (110 aa)
COX5BCytochrome c oxidase subunit 5B. (129 aa)
H6PDHexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. (802 aa)
NME9NME/NM23 family member 9; Belongs to the NDK family. (269 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (333 aa)
LRPPRCPPR_long domain-containing protein. (1388 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
COX11Cytochrome c oxidase copper chaperone COX11. (276 aa)
COX4I2Cytochrome c oxidase subunit 4I2. (171 aa)
COX4I1Cytochrome c oxidase subunit 4I1. (169 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (625 aa)
ENSPPAP00000034038Uncharacterized protein. (256 aa)
COX6B1Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (86 aa)
ENSPPAP00000033668Uncharacterized protein. (85 aa)
LOC100995377Uncharacterized protein. (557 aa)
ENSPPAP0000003279514_3_3 domain-containing protein; Belongs to the 14-3-3 family. (209 aa)
TXNRD3Thioredoxin reductase 3. (642 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
LOC10097851514_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
COX7BCytochrome c oxidase subunit 7B. (80 aa)
COX16Cytochrome c oxidase assembly factor COX16. (106 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (873 aa)
LAMTOR4Uncharacterized protein. (137 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
LAMTOR2Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (125 aa)
ENSPPAP00000028807Thioredoxin domain-containing protein. (166 aa)
SESN2Sestrin 2. (480 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
COX19Cytochrome c oxidase assembly factor COX19. (90 aa)
ENSPPAP00000026327Thioredoxin domain-containing protein. (188 aa)
SCO1SCO cytochrome c oxidase assembly protein 1. (301 aa)
DESI2Desumoylating isopeptidase 2. (194 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
ENSPPAP0000002550914_3_3 domain-containing protein; Belongs to the 14-3-3 family. (234 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSPPAP00000024731Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (117 aa)
TSC1TSC complex subunit 1. (1164 aa)
LOC100982423Uncharacterized protein. (78 aa)
CRYBB3Crystallin beta B3; Belongs to the beta/gamma-crystallin family. (211 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (243 aa)
GSRGlutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (522 aa)
C1orf198Chromosome 1 open reading frame 198. (327 aa)
DESI1Desumoylating isopeptidase 1. (168 aa)
AGO1Argonaute RISC component 1; Belongs to the argonaute family. (857 aa)
TACO1Translational activator of cytochrome c oxidase I. (297 aa)
RRAGBRas related GTP binding B. (374 aa)
LAMTOR3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
PRDX2Peroxiredoxin 2. (198 aa)
RHEBL1RHEB like 1. (183 aa)
TSC2TSC complex subunit 2. (1807 aa)
COX7CCytochrome c oxidase subunit 7C, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...] (63 aa)
COX7A2LCytochrome c oxidase subunit 7A2 like. (114 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
MLST8MTOR associated protein, LST8 homolog. (327 aa)
COX20Cytochrome c oxidase assembly factor COX20. (130 aa)
ENSPPAP00000019421Uncharacterized protein. (75 aa)
ENSPPAP00000019251Uncharacterized protein. (62 aa)
ENSPPAP00000018449Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (90 aa)
SLC38A9Solute carrier family 38 member 9. (561 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
TXNRD1Thioredoxin reductase 1. (648 aa)
TXNDC11Thioredoxin domain containing 11. (956 aa)
LOC100974009Uncharacterized protein. (184 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
PRDX5Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (214 aa)
MOV10Mov10 RISC complex RNA helicase. (1005 aa)
LOC10098440114_3_3 domain-containing protein; Belongs to the 14-3-3 family. (238 aa)
NME8NME/NM23 family member 8. (588 aa)
LOC100983479Thioredoxin domain-containing protein. (106 aa)
COX6A2Cytochrome c oxidase subunit 6A2. (87 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
G6PDGlucose-6-phosphate dehydrogenase. (560 aa)
RRM2BRibonucleotide reductase regulatory TP53 inducible subunit M2B. (350 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (545 aa)
RRAGCRas related GTP binding C. (399 aa)
RRAGDRas related GTP binding D. (400 aa)
ENSPPAP00000013152Uncharacterized protein. (128 aa)
PTENUncharacterized protein. (542 aa)
GATCGlutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatC family. (136 aa)
ENSPPAP0000001192314_3_3 domain-containing protein; Belongs to the 14-3-3 family. (238 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
COX5A-2Cytochrome c oxidase subunit 5A, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...] (138 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
TNRC6BTrinucleotide repeat containing adaptor 6B. (1833 aa)
SURF1SURF1-like protein; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Belongs to the SURF1 family. (264 aa)
COX8ACytochrome c oxidase subunit 8A, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...] (69 aa)
GLS2Glutaminase 2. (602 aa)
ENSPPAP00000009855Thioredoxin domain-containing protein. (82 aa)
RHEBUncharacterized protein. (173 aa)
SESN3Sestrin 3. (522 aa)
DDIT4DNA damage inducible transcript 4. (232 aa)
DDIT4LDNA damage inducible transcript 4 like. (193 aa)
LOC103785895Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (110 aa)
COX6B2Cytochrome c oxidase subunit 6B2. (88 aa)
GLSGlutaminase. (565 aa)
TRIRTelomerase RNA component interacting RNase. (172 aa)
CRYGNCrystallin gamma N; Belongs to the beta/gamma-crystallin family. (182 aa)
COX7B2Cytochrome c oxidase subunit 7B2. (81 aa)
CYCSCytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSPPAP00000003283Cytochrome c oxidase subunit 6A, mitochondrial. (109 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
RRAGARas related GTP binding A. (313 aa)
NPVFNeuropeptide VF precursor. (196 aa)
SCO2SCO cytochrome c oxidase assembly protein 2. (266 aa)
COX7A2Cytochrome c oxidase subunit 7A2. (115 aa)
ENSPPAP0000004322514_3_3 domain-containing protein; Belongs to the 14-3-3 family. (288 aa)
PRKAA2Non-specific serine/threonine protein kinase. (542 aa)
TXNDC8Thioredoxin domain containing 8. (127 aa)
COX7A1Cytochrome c oxidase subunit 7A1. (79 aa)
ENSPPAP00000041551Uncharacterized protein. (69 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (173 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (125 aa)
KIAA1671KIAA1671. (1802 aa)
COX6A1Cytochrome c oxidase subunit 6A, mitochondrial. (109 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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