STRINGSTRING
ENSPPAP00000031361 ENSPPAP00000031361 RECQL4 RECQL4 RCBTB2 RCBTB2 RPA1 RPA1 ENSPPAP00000035310 ENSPPAP00000035310 RAD51B RAD51B RFC2 RFC2 RFC4 RFC4 RAD51 RAD51 RFC1 RFC1 KAT5 KAT5 POLD3 POLD3 EXD2 EXD2 POLE3 POLE3 KXD1 KXD1 RAD9A RAD9A ENSPPAP00000016638 ENSPPAP00000016638 RFC3 RFC3 SPIDR SPIDR RCBTB1 RCBTB1 BLM BLM MEIOB MEIOB HUS1 HUS1 ENSPPAP00000019542 ENSPPAP00000019542 BRCA2 BRCA2 RMI1 RMI1 RAD9B RAD9B SLX1A SLX1A TDRD3 TDRD3 ENSPPAP00000003540 ENSPPAP00000003540 NBN NBN CHEK1 CHEK1 UBC UBC PALB2 PALB2 HUS1B HUS1B LOC100990877 LOC100990877 MUS81 MUS81 TOPBP1 TOPBP1 RBBP8 RBBP8 TOP3A TOP3A POLK POLK RAD51D RAD51D ATM ATM ENSPPAP00000009924 ENSPPAP00000009924 GEN1 GEN1 RAD1 RAD1 RAD50 RAD50 ENSPPAP00000013353 ENSPPAP00000013353 POLD2 POLD2 POLD1 POLD1 ENSPPAP00000014117 ENSPPAP00000014117 POLE4 POLE4 RMI2 RMI2 BRCA1 BRCA1 XRCC2 XRCC2 PCNA PCNA ANKRD31 ANKRD31 RTEL1-2 RTEL1-2 POLE2 POLE2 POLE POLE RAD51AP1 RAD51AP1 RHNO1 RHNO1 RPS27A RPS27A MRE11 MRE11 RAD51C RAD51C POLD4 POLD4 EME2 EME2 ENSPPAP00000026192 ENSPPAP00000026192 WRN WRN BRIP1 BRIP1 DNA2 DNA2 ATRIP ATRIP RPA3 RPA3 RTEL1 RTEL1 POLH POLH EXO1 EXO1 XRCC3 XRCC3 ENSPPAP00000031315 ENSPPAP00000031315 RAD17 RAD17 RFC5 RFC5 SLX4 SLX4 ATR ATR BARD1 BARD1 EME1 EME1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPPAP00000031361Uncharacterized protein. (207 aa)
RECQL4RecQ like helicase 4. (1208 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (556 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
ENSPPAP00000035310Uncharacterized protein. (121 aa)
RAD51BRAD51 paralog B. (359 aa)
RFC2Replication factor C subunit 2. (320 aa)
RFC4Replication factor C subunit 4. (363 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa)
RFC1Replication factor C subunit 1. (1148 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
POLD3Uncharacterized protein. (459 aa)
EXD2Exonuclease 3'-5' domain containing 2. (621 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (146 aa)
KXD1Ubiquitin-like domain-containing protein. (231 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (391 aa)
ENSPPAP00000016638Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (612 aa)
RFC3Replication factor C subunit 3. (356 aa)
SPIDRScaffold protein involved in DNA repair. (915 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
BLMBLM RecQ like helicase. (1417 aa)
MEIOBUncharacterized protein. (344 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (259 aa)
ENSPPAP00000019542Ubiquitin-like domain-containing protein. (136 aa)
BRCA2BRCA2 DNA repair associated. (3417 aa)
RMI1RecQ mediated genome instability 1. (625 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (429 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa)
TDRD3Tudor domain containing 3. (744 aa)
ENSPPAP00000003540Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (246 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
CHEK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (476 aa)
UBCUncharacterized protein. (153 aa)
PALB2Partner and localizer of BRCA2. (1186 aa)
HUS1BCheckpoint protein; Belongs to the HUS1 family. (278 aa)
LOC100990877Ubiquitin-like domain-containing protein. (156 aa)
MUS81MUS81 structure-specific endonuclease subunit. (551 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1473 aa)
RBBP8RB binding protein 8, endonuclease. (895 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa)
POLKDNA polymerase kappa. (897 aa)
RAD51DRAD51 paralog D. (348 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
ENSPPAP00000009924Ubiquitin-like domain-containing protein. (84 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (908 aa)
RAD1RAD1 checkpoint DNA exonuclease. (282 aa)
RAD50Zinc-hook domain-containing protein. (1312 aa)
ENSPPAP00000013353Uncharacterized protein. (117 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
POLD1DNA polymerase. (1133 aa)
ENSPPAP00000014117Ubiquitin-like domain-containing protein. (145 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (116 aa)
RMI2RecQ mediated genome instability 2. (126 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1849 aa)
XRCC2X-ray repair cross complementing 2. (280 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
ANKRD31Ankyrin repeat domain 31. (1930 aa)
RTEL1-2Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1103 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa)
RAD51AP1RAD51 associated protein 1. (355 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (238 aa)
RPS27ARibosomal protein S27a. (156 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (692 aa)
RAD51CRAD51 paralog C. (376 aa)
POLD4Uncharacterized protein. (107 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (378 aa)
ENSPPAP00000026192Uncharacterized protein. (86 aa)
WRNWRN RecQ like helicase. (1405 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1249 aa)
DNA2DNA replication helicase/nuclease 2. (1060 aa)
ATRIPATR interacting protein. (790 aa)
RPA3Replication protein A3. (121 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1318 aa)
POLHDNA polymerase eta. (712 aa)
EXO1Exonuclease 1. (846 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (348 aa)
ENSPPAP00000031315Uncharacterized protein. (560 aa)
RAD17RAD17 checkpoint clamp loader component. (681 aa)
RFC5Replication factor C subunit 5. (354 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1833 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2614 aa)
BARD1BRCA1 associated RING domain 1. (777 aa)
EME1Essential meiotic structure-specific endonuclease 1. (571 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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