Your Input: | |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (485 aa) |
| | ENSPPAP00000018916 | Uncharacterized protein. (305 aa) |
| | ENSPPAP00000019066 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (95 aa) |
| | ENSPPAP00000019542 | Ubiquitin-like domain-containing protein. (136 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (280 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (301 aa) |
| | LOC100985638 | Histone H2B; Belongs to the histone H2B family. (167 aa) |
| | ANKRD31 | Ankyrin repeat domain 31. (1930 aa) |
| | RTEL1-2 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1103 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | ENSPPAP00000020661 | Uncharacterized protein. (414 aa) |
| | ENSPPAP00000021658 | Uncharacterized protein. (339 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (307 aa) |
| | SIRT6 | Sirtuin 6. (355 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (355 aa) |
| | ENSPPAP00000023005 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (285 aa) |
| | RPS27A | Ribosomal protein S27a. (156 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (692 aa) |
| | RNF4 | Ring finger protein 4. (190 aa) |
| | ENSPPAP00000024179 | Uncharacterized protein; Belongs to the histone H2B family. (54 aa) |
| | ENSPPAP00000024365 | Histone domain-containing protein; Belongs to the histone H2B family. (113 aa) |
| | TIMELESS | Timeless circadian regulator. (1208 aa) |
| | RAD51C | RAD51 paralog C. (376 aa) |
| | SIRT7 | Sirtuin 7. (353 aa) |
| | POLD4 | Uncharacterized protein. (107 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (378 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (727 aa) |
| | LOC100988594 | Histone domain-containing protein; Belongs to the histone H2B family. (155 aa) |
| | ENSPPAP00000026192 | Uncharacterized protein. (86 aa) |
| | ENSPPAP00000026290 | Reverse transcriptase domain-containing protein. (289 aa) |
| | ABL1 | Tyrosine-protein kinase. (1149 aa) |
| | ENSPPAP00000027404 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (246 aa) |
| | WRN | WRN RecQ like helicase. (1405 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1249 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1060 aa) |
| | ENSPPAP00000028443 | Rad60-SLD domain-containing protein. (118 aa) |
| | ATRIP | ATR interacting protein. (790 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1318 aa) |
| | POLH | DNA polymerase eta. (712 aa) |
| | EXO1 | Exonuclease 1. (846 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (348 aa) |
| | ENSPPAP00000031315 | Uncharacterized protein. (560 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa) |
| | ENSPPAP00000031361 | Uncharacterized protein. (207 aa) |
| | RECQL4 | RecQ like helicase 4. (1208 aa) |
| | ENSPPAP00000032178 | Histone H2B; Belongs to the histone H2B family. (138 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (556 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (415 aa) |
| | ENSPPAP00000032567 | Uncharacterized protein. (411 aa) |
| | MDC1 | Uncharacterized protein. (1859 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (317 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1977 aa) |
| | ENSPPAP00000035310 | Uncharacterized protein. (121 aa) |
| | RAD51B | RAD51 paralog B. (359 aa) |
| | RFC2 | Replication factor C subunit 2. (320 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa) |
| | LOC100988917 | Histone domain-containing protein; Belongs to the histone H2B family. (153 aa) |
| | RFC1 | Replication factor C subunit 1. (1148 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa) |
| | POLD3 | Uncharacterized protein. (459 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (621 aa) |
| | PPP4R2 | Protein phosphatase 4 regulatory subunit 2. (379 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (146 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (465 aa) |
| | KXD1 | Ubiquitin-like domain-containing protein. (231 aa) |
| | LOC100987671 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (88 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2614 aa) |
| | ENSPPAP00000040497 | Uncharacterized protein. (255 aa) |
| | ENSPPAP00000040700 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (140 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (777 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (571 aa) |
| | UBE2V2 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (151 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (238 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1833 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa) |
| | RFC5 | Replication factor C subunit 5. (354 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (681 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1058 aa) |
| | LOC100975795 | Histone domain-containing protein; Belongs to the histone H2B family. (126 aa) |
| | LOC103783476 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC112440134 | Histone H4. (103 aa) |
| | H4C5 | Histone H4. (103 aa) |
| | SUMO3 | Small ubiquitin-related modifier. (103 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3417 aa) |
| | LOC100981824 | Histone H4. (103 aa) |
| | RMI1 | RecQ mediated genome instability 1. (625 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (429 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa) |
| | TDRD3 | Tudor domain containing 3. (744 aa) |
| | H2BC5 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | UBE2I | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (417 aa) |
| | LOC112440134-2 | Histone H4. (103 aa) |
| | ENSPPAP00000003540 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (246 aa) |
| | H2BC10 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC112440134-3 | Histone H4. (103 aa) |
| | H4C7 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (98 aa) |
| | LOC100976584 | Histone H4. (103 aa) |
| | LOC100977926 | Uncharacterized LOC100977926. (103 aa) |
| | LOC112440134-4 | Histone H4. (103 aa) |
| | ENSPPAP00000004030 | Uncharacterized protein. (272 aa) |
| | H2BC1 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | ENSPPAP00000004466 | MPN domain-containing protein. (294 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa) |
| | LOC100992212 | Histone H4. (103 aa) |
| | H3-4 | Histone cluster 3 H3. (136 aa) |
| | CHEK1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (476 aa) |
| | RNF169 | Ring finger protein 169. (615 aa) |
| | LOC100985450 | Histone H2B type 1. (126 aa) |
| | UBC | Uncharacterized protein. (153 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1186 aa) |
| | LOC100987642 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSPPAP00000005256 | Uncharacterized protein. (83 aa) |
| | ENSPPAP00000005309 | Reverse transcriptase domain-containing protein. (279 aa) |
| | LOC100979846 | Histone H2B type 1. (126 aa) |
| | HUS1B | Checkpoint protein; Belongs to the HUS1 family. (278 aa) |
| | H2BC9 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSPPAP00000005762 | Reverse transcriptase domain-containing protein. (276 aa) |
| | H2BC11 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC100990877 | Ubiquitin-like domain-containing protein. (156 aa) |
| | LOC100981154 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (551 aa) |
| | ENSPPAP00000006213 | Reverse transcriptase domain-containing protein. (247 aa) |
| | H2BC13 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1473 aa) |
| | ENSPPAP00000006330 | Uncharacterized protein. (251 aa) |
| | LOC100985433 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (895 aa) |
| | H2BC14 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa) |
| | H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC6 | Histone H2B type 1. (126 aa) |
| | POLK | DNA polymerase kappa. (897 aa) |
| | LOC112440134-5 | Histone H4. (103 aa) |
| | RAD51D | RAD51 paralog D. (348 aa) |
| | ENSPPAP00000008048 | Rad60-SLD domain-containing protein. (62 aa) |
| | ENSPPAP00000008828 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (133 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | LOC100988108 | Rad60-SLD domain-containing protein. (74 aa) |
| | ENSPPAP00000009924 | Ubiquitin-like domain-containing protein. (84 aa) |
| | UBE2N | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (148 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (908 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (282 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1365 aa) |
| | CLSPN | Claspin. (1338 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (407 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1312 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (317 aa) |
| | ENSPPAP00000013353 | Uncharacterized protein. (117 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (504 aa) |
| | POLD1 | DNA polymerase. (1133 aa) |
| | ENSPPAP00000014117 | Ubiquitin-like domain-containing protein. (145 aa) |
| | ENSPPAP00000014227 | Uncharacterized protein. (210 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (116 aa) |
| | RMI2 | RecQ mediated genome instability 2. (126 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1849 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (391 aa) |
| | LOC100969533 | Histone domain-containing protein; Belongs to the histone H2B family. (175 aa) |
| | ENSPPAP00000016638 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (612 aa) |
| | ENSPPAP00000017476 | Uncharacterized protein. (263 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (570 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | ENSPPAP00000017700 | Uncharacterized protein. (277 aa) |
| | SPIDR | Scaffold protein involved in DNA repair. (915 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4672 aa) |
| | ENSPPAP00000018027 | Uncharacterized protein. (238 aa) |
| | BLM | BLM RecQ like helicase. (1417 aa) |
| | ENSPPAP00000018238 | Uncharacterized protein. (302 aa) |
| | ENSPPAP00000018281 | Uncharacterized protein. (303 aa) |
| | ENSPPAP00000018336 | Uncharacterized protein. (311 aa) |
| | MEIOB | Uncharacterized protein. (344 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (573 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (259 aa) |
