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BRCA2 BRCA2 RMI1 RMI1 SLX1A SLX1A NBN NBN PALB2 PALB2 MUS81 MUS81 RBBP8 RBBP8 TOP3A TOP3A RAD51D RAD51D ATM ATM GEN1 GEN1 RAD50 RAD50 RMI2 RMI2 BRCA1 BRCA1 ENSPPAP00000016638 ENSPPAP00000016638 SPIDR SPIDR BLM BLM XRCC2 XRCC2 ANKRD31 ANKRD31 RAD51AP1 RAD51AP1 MRE11 MRE11 RAD51C RAD51C EME2 EME2 WRN WRN BRIP1 BRIP1 DNA2 DNA2 EXO1 EXO1 XRCC3 XRCC3 ENSPPAP00000031361 ENSPPAP00000031361 RECQL4 RECQL4 RAD51B RAD51B RAD51 RAD51 KAT5 KAT5 BARD1 BARD1 EME1 EME1 SLX4 SLX4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BRCA2BRCA2 DNA repair associated. (3417 aa)
RMI1RecQ mediated genome instability 1. (625 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
PALB2Partner and localizer of BRCA2. (1186 aa)
MUS81MUS81 structure-specific endonuclease subunit. (551 aa)
RBBP8RB binding protein 8, endonuclease. (895 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa)
RAD51DRAD51 paralog D. (348 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (908 aa)
RAD50Zinc-hook domain-containing protein. (1312 aa)
RMI2RecQ mediated genome instability 2. (126 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1849 aa)
ENSPPAP00000016638Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (612 aa)
SPIDRScaffold protein involved in DNA repair. (915 aa)
BLMBLM RecQ like helicase. (1417 aa)
XRCC2X-ray repair cross complementing 2. (280 aa)
ANKRD31Ankyrin repeat domain 31. (1930 aa)
RAD51AP1RAD51 associated protein 1. (355 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (692 aa)
RAD51CRAD51 paralog C. (376 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (378 aa)
WRNWRN RecQ like helicase. (1405 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1249 aa)
DNA2DNA replication helicase/nuclease 2. (1060 aa)
EXO1Exonuclease 1. (846 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (348 aa)
ENSPPAP00000031361Uncharacterized protein. (207 aa)
RECQL4RecQ like helicase 4. (1208 aa)
RAD51BRAD51 paralog B. (359 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
BARD1BRCA1 associated RING domain 1. (777 aa)
EME1Essential meiotic structure-specific endonuclease 1. (571 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1833 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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