STRINGSTRING
SUMO3 SUMO3 ACTR5 ACTR5 ZFP42 ZFP42 UBE2I UBE2I ENSPPAP00000003540 ENSPPAP00000003540 RAD23A RAD23A INO80D INO80D INO80C INO80C UBC UBC ENSPPAP00000005391 ENSPPAP00000005391 COPS7A COPS7A RNF111 RNF111 VTCN1 VTCN1 LOC100990877 LOC100990877 WDR76 WDR76 COPS4 COPS4 POLK POLK COPS7B COPS7B ENSPPAP00000008048 ENSPPAP00000008048 VWA5B2 VWA5B2 ENSPPAP00000008828 ENSPPAP00000008828 LOC100988108 LOC100988108 ENSPPAP00000009924 ENSPPAP00000009924 CDK7 CDK7 UBE2N UBE2N COPS8 COPS8 CUL4B CUL4B COPS2 COPS2 ACTR8 ACTR8 GTF2H1 GTF2H1 ENSPPAP00000013353 ENSPPAP00000013353 POLD2 POLD2 POLD1 POLD1 ENSPPAP00000014117 ENSPPAP00000014117 ATAD5 ATAD5 POLE4 POLE4 NFRKB NFRKB PIAS3 PIAS3 COPS5 COPS5 ENSPPAP00000017097 ENSPPAP00000017097 SUMO1 SUMO1 RPA1 RPA1 ENSPPAP00000034007 ENSPPAP00000034007 GTF2H4 GTF2H4 GTF2H3 GTF2H3 RUVBL1 RUVBL1 XPA XPA ENSPPAP00000035310 ENSPPAP00000035310 MCRS1 MCRS1 RFC2 RFC2 BIVM BIVM PARP3 PARP3 PARP1 PARP1 RFC4 RFC4 ENSPPAP00000036638 ENSPPAP00000036638 RAD23B RAD23B PIAS1 PIAS1 TFPT TFPT RFC1 RFC1 INO80 INO80 POLD3 POLD3 CETN3 CETN3 COPS6 COPS6 ENSPPAP00000028443 ENSPPAP00000028443 COPS3 COPS3 ACTB ACTB GTF2H5 GTF2H5 POLE3 POLE3 KXD1 KXD1 LOC100987671 LOC100987671 ENSPPAP00000040700 ENSPPAP00000040700 UBE2V2 UBE2V2 XPC XPC INO80E INO80E ERCC1 ERCC1 ERCC2 ERCC2 RFC5 RFC5 LIG1 LIG1 VWA5B1 VWA5B1 CHD1L CHD1L RCBTB2 RCBTB2 CETN2 CETN2 INO80B INO80B XRCC1 XRCC1 LOC100991563 LOC100991563 RPA3 RPA3 NFATC2IP NFATC2IP RBX1 RBX1 ACTL6A ACTL6A RFC3 RFC3 RCBTB1 RCBTB1 ENSPPAP00000018396 ENSPPAP00000018396 MEIOB MEIOB ENSPPAP00000018781 ENSPPAP00000018781 ENSPPAP00000019066 ENSPPAP00000019066 ENSPPAP00000019542 ENSPPAP00000019542 YY2 YY2 PCNA PCNA RPAP3 RPAP3 POLE2 POLE2 MNAT1 MNAT1 ENSPPAP00000020922 ENSPPAP00000020922 POLE POLE LIG3 LIG3 CUL4A CUL4A USP45 USP45 RPS27A RPS27A CCNH CCNH PARP2 PARP2 ENSPPAP00000024326 ENSPPAP00000024326 DDB1 DDB1 POLD4 POLD4 WBP1 WBP1 ERCC4 ERCC4 ERCC3 ERCC3 VWA5A VWA5A GPS1 GPS1 YY1 YY1 GTF2H2 GTF2H2 KCTD2 KCTD2 DDB2 DDB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SUMO3Small ubiquitin-related modifier. (103 aa)
ACTR5Actin related protein 5; Belongs to the actin family. (607 aa)
ZFP42ZFP42 zinc finger protein. (310 aa)
UBE2IUbiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
ENSPPAP00000003540Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (246 aa)
RAD23ARAD23 homolog A, nucleotide excision repair protein. (363 aa)
INO80DINO80 complex subunit D. (1027 aa)
INO80CINO80 complex subunit C. (228 aa)
UBCUncharacterized protein. (153 aa)
ENSPPAP00000005391Rad60-SLD domain-containing protein. (84 aa)
COPS7ACOP9 signalosome subunit 7A. (275 aa)
RNF111Ring finger protein 111. (993 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (285 aa)
LOC100990877Ubiquitin-like domain-containing protein. (156 aa)
WDR76WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (625 aa)
COPS4COP9 signalosome subunit 4. (424 aa)
POLKDNA polymerase kappa. (897 aa)
COPS7BCOP9 signalosome subunit 7B. (278 aa)
ENSPPAP00000008048Rad60-SLD domain-containing protein. (62 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1242 aa)
ENSPPAP00000008828UBIQUITIN_CONJUGAT_2 domain-containing protein. (133 aa)
LOC100988108Rad60-SLD domain-containing protein. (74 aa)
ENSPPAP00000009924Ubiquitin-like domain-containing protein. (84 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
UBE2NUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (148 aa)
COPS8COP9 signalosome subunit 8. (209 aa)
CUL4BCullin 4B; Belongs to the cullin family. (932 aa)
COPS2COP9 signalosome subunit 2. (450 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa)
GTF2H1General transcription factor IIH subunit 1. (548 aa)
ENSPPAP00000013353Uncharacterized protein. (117 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
POLD1DNA polymerase. (1133 aa)
ENSPPAP00000014117Ubiquitin-like domain-containing protein. (145 aa)
ATAD5ATPase family AAA domain containing 5. (1832 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (116 aa)
NFRKBNuclear factor related to kappaB binding protein. (1299 aa)
PIAS3Protein inhibitor of activated STAT 3. (628 aa)
COPS5COP9 signalosome subunit 5. (333 aa)
ENSPPAP00000017097Rad60-SLD domain-containing protein. (140 aa)
SUMO1Ubiquitin-like domain-containing protein. (146 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
ENSPPAP00000034007Protein kinase domain-containing protein. (324 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (462 aa)
GTF2H3General transcription factor IIH subunit 3. (308 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
ENSPPAP00000035310Uncharacterized protein. (121 aa)
MCRS1Microspherule protein 1. (475 aa)
RFC2Replication factor C subunit 2. (320 aa)
BIVMBIVM-ERCC5 readthrough. (1640 aa)
PARP3Poly [ADP-ribose] polymerase. (539 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
RFC4Replication factor C subunit 4. (363 aa)
ENSPPAP00000036638Uncharacterized protein. (266 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (409 aa)
PIAS1Protein inhibitor of activated STAT 1. (653 aa)
TFPTTCF3 fusion partner. (253 aa)
RFC1Replication factor C subunit 1. (1148 aa)
INO80INO80 complex ATPase subunit. (1556 aa)
POLD3Uncharacterized protein. (459 aa)
CETN3Centrin 3. (191 aa)
COPS6COP9 signalosome subunit 6. (327 aa)
ENSPPAP00000028443Rad60-SLD domain-containing protein. (118 aa)
COPS3COP9 signalosome subunit 3. (421 aa)
ACTBActin beta; Belongs to the actin family. (372 aa)
GTF2H5General transcription factor IIH subunit 5. (71 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (146 aa)
KXD1Ubiquitin-like domain-containing protein. (231 aa)
LOC100987671UBIQUITIN_CONJUGAT_2 domain-containing protein. (88 aa)
ENSPPAP00000040700UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (140 aa)
UBE2V2UBIQUITIN_CONJUGAT_2 domain-containing protein. (151 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (946 aa)
INO80EINO80 complex subunit E. (244 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
RFC5Replication factor C subunit 5. (354 aa)
LIG1DNA ligase. (919 aa)
VWA5B1Von Willebrand factor A domain containing 5B1. (1215 aa)
CHD1LChromodomain helicase DNA binding protein 1 like. (921 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (556 aa)
CETN2Centrin 2. (172 aa)
INO80BPAPA-1 domain-containing protein. (356 aa)
XRCC1X-ray repair cross complementing 1. (556 aa)
LOC100991563Rad60-SLD domain-containing protein. (72 aa)
RPA3Replication protein A3. (121 aa)
NFATC2IPNuclear factor of activated T cells 2 interacting protein. (419 aa)
RBX1Ring-box 1. (108 aa)
ACTL6AActin like 6A; Belongs to the actin family. (430 aa)
RFC3Replication factor C subunit 3. (356 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
ENSPPAP00000018396MPN domain-containing protein. (188 aa)
MEIOBUncharacterized protein. (344 aa)
ENSPPAP00000018781Uncharacterized protein. (136 aa)
ENSPPAP00000019066UBIQUITIN_CONJUGAT_2 domain-containing protein. (95 aa)
ENSPPAP00000019542Ubiquitin-like domain-containing protein. (136 aa)
YY2YY2 transcription factor. (355 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
RPAP3RNA polymerase II associated protein 3. (665 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
ENSPPAP00000020922PCI domain-containing protein. (163 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa)
LIG3DNA ligase. (1008 aa)
CUL4ACullin 4A; Belongs to the cullin family. (669 aa)
USP45Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (814 aa)
RPS27ARibosomal protein S27a. (156 aa)
CCNHCyclin H; Belongs to the cyclin family. (325 aa)
PARP2Poly [ADP-ribose] polymerase. (565 aa)
ENSPPAP00000024326Uncharacterized protein. (370 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
POLD4Uncharacterized protein. (107 aa)
WBP1Uncharacterized protein. (308 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa)
VWA5AVon Willebrand factor A domain containing 5A. (786 aa)
GPS1G protein pathway suppressor 1. (539 aa)
YY1Uncharacterized protein. (370 aa)
GTF2H2General transcription factor IIH subunit. (395 aa)
KCTD2Uncharacterized protein. (64 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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