STRINGSTRING
ERCC1 ERCC1 DDB2 DDB2 ENSPPAP00000003540 ENSPPAP00000003540 UBC UBC LOC100990877 LOC100990877 POLK POLK ENSPPAP00000009924 ENSPPAP00000009924 CUL4B CUL4B GTF2H1 GTF2H1 ENSPPAP00000013353 ENSPPAP00000013353 POLD2 POLD2 POLD1 POLD1 POLE4 POLE4 RBX1 RBX1 RFC3 RFC3 RCBTB1 RCBTB1 ENSPPAP00000018781 ENSPPAP00000018781 ERCC2 ERCC2 PCNA PCNA POLE2 POLE2 POLE POLE CUL4A CUL4A RPS27A RPS27A RFC5 RFC5 PARP2 PARP2 DDB1 DDB1 POLD4 POLD4 ERCC4 ERCC4 ERCC3 ERCC3 GTF2H2 GTF2H2 RPA3 RPA3 RCBTB2 RCBTB2 CHD1L CHD1L RPA1 RPA1 GTF2H4 GTF2H4 GTF2H3 GTF2H3 XPA XPA ENSPPAP00000035310 ENSPPAP00000035310 RFC2 RFC2 BIVM BIVM PARP3 PARP3 PARP1 PARP1 RFC4 RFC4 RFC1 RFC1 POLD3 POLD3 GTF2H5 GTF2H5 POLE3 POLE3 KXD1 KXD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
ENSPPAP00000003540Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (246 aa)
UBCUncharacterized protein. (153 aa)
LOC100990877Ubiquitin-like domain-containing protein. (156 aa)
POLKDNA polymerase kappa. (897 aa)
ENSPPAP00000009924Ubiquitin-like domain-containing protein. (84 aa)
CUL4BCullin 4B; Belongs to the cullin family. (932 aa)
GTF2H1General transcription factor IIH subunit 1. (548 aa)
ENSPPAP00000013353Uncharacterized protein. (117 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
POLD1DNA polymerase. (1133 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (116 aa)
RBX1Ring-box 1. (108 aa)
RFC3Replication factor C subunit 3. (356 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
ENSPPAP00000018781Uncharacterized protein. (136 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa)
CUL4ACullin 4A; Belongs to the cullin family. (669 aa)
RPS27ARibosomal protein S27a. (156 aa)
RFC5Replication factor C subunit 5. (354 aa)
PARP2Poly [ADP-ribose] polymerase. (565 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
POLD4Uncharacterized protein. (107 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa)
GTF2H2General transcription factor IIH subunit. (395 aa)
RPA3Replication protein A3. (121 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (556 aa)
CHD1LChromodomain helicase DNA binding protein 1 like. (921 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (462 aa)
GTF2H3General transcription factor IIH subunit 3. (308 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
ENSPPAP00000035310Uncharacterized protein. (121 aa)
RFC2Replication factor C subunit 2. (320 aa)
BIVMBIVM-ERCC5 readthrough. (1640 aa)
PARP3Poly [ADP-ribose] polymerase. (539 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
RFC4Replication factor C subunit 4. (363 aa)
RFC1Replication factor C subunit 1. (1148 aa)
POLD3Uncharacterized protein. (459 aa)
GTF2H5General transcription factor IIH subunit 5. (71 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (146 aa)
KXD1Ubiquitin-like domain-containing protein. (231 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.