STRINGSTRING
XRCC1 XRCC1 RPA3 RPA3 COPS3 COPS3 USP7 USP7 GTF2H2 GTF2H2 GPS1 GPS1 PPP1R42 PPP1R42 ERCC3 ERCC3 ENSPPAP00000025484 ENSPPAP00000025484 ERCC4 ERCC4 POLD4 POLD4 POLR2H POLR2H TCEA2 TCEA2 DDB1 DDB1 CCNH CCNH RPS27A RPS27A CUL4A CUL4A NRDE2 NRDE2 LIG3 LIG3 POLE POLE ENSPPAP00000020922 ENSPPAP00000020922 MNAT1 MNAT1 POLE2 POLE2 POLR2I POLR2I PCNA PCNA ENSPPAP00000019542 ENSPPAP00000019542 EP300 EP300 ENSPPAP00000018781 ENSPPAP00000018781 MEIOB MEIOB ENSPPAP00000018396 ENSPPAP00000018396 ENSPPAP00000018389 ENSPPAP00000018389 HMGN1 HMGN1 RCBTB1 RCBTB1 RFC3 RFC3 RBX1 RBX1 COPS5 COPS5 AQR AQR POLE4 POLE4 ATAD5 ATAD5 PRPF19 PRPF19 ENSPPAP00000014117 ENSPPAP00000014117 POLD1 POLD1 POLD2 POLD2 ENSPPAP00000013353 ENSPPAP00000013353 GTF2H1 GTF2H1 COPS2 COPS2 ENSPPAP00000012418 ENSPPAP00000012418 ERCC8 ERCC8 ELL ELL CUL4B CUL4B COPS8 COPS8 CDK7 CDK7 ENSPPAP00000009924 ENSPPAP00000009924 PHF3 PHF3 COPS7B COPS7B POLK POLK COPS4 COPS4 POLR2F POLR2F LOC100990877 LOC100990877 TCEANC TCEANC COPS7A COPS7A UBC UBC ZNF830 ZNF830 ENSPPAP00000003540 ENSPPAP00000003540 SPOCD1 SPOCD1 TCEA1 TCEA1 ERCC6 ERCC6 POLR2E POLR2E POLR2A POLR2A RFC5 RFC5 TCEA3 TCEA3 ERCC2 ERCC2 POLR2D POLR2D USP40 USP40 UVSSA UVSSA RPA1 RPA1 POLR2G POLR2G ENSPPAP00000034007 ENSPPAP00000034007 GTF2H4 GTF2H4 GTF2H3 GTF2H3 POLR2B POLR2B POLR2K POLR2K XPA XPA ENSPPAP00000035310 ENSPPAP00000035310 ENSPPAP00000035732 ENSPPAP00000035732 RFC2 RFC2 BIVM BIVM RFC4 RFC4 TCEANC2 TCEANC2 RFC1 RFC1 ISY1 ISY1 POLD3 POLD3 PPIE PPIE ENSPPAP00000039593 ENSPPAP00000039593 COPS6 COPS6 GTF2H5 GTF2H5 POLE3 POLE3 KXD1 KXD1 POLR2C POLR2C XAB2 XAB2 ERCC1 ERCC1 LIG1 LIG1 RCBTB2 RCBTB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
XRCC1X-ray repair cross complementing 1. (556 aa)
RPA3Replication protein A3. (121 aa)
COPS3COP9 signalosome subunit 3. (421 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1109 aa)
GTF2H2General transcription factor IIH subunit. (395 aa)
GPS1G protein pathway suppressor 1. (539 aa)
PPP1R42Uncharacterized protein. (347 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa)
ENSPPAP00000025484Uncharacterized protein. (77 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
POLD4Uncharacterized protein. (107 aa)
POLR2HDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
TCEA2Transcription elongation factor A2. (299 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
CCNHCyclin H; Belongs to the cyclin family. (325 aa)
RPS27ARibosomal protein S27a. (156 aa)
CUL4ACullin 4A; Belongs to the cullin family. (669 aa)
NRDE2NRDE-2, necessary for RNA interference, domain containing. (1144 aa)
LIG3DNA ligase. (1008 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa)
ENSPPAP00000020922PCI domain-containing protein. (163 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
ENSPPAP00000019542Ubiquitin-like domain-containing protein. (136 aa)
EP300E1A binding protein p300. (2411 aa)
ENSPPAP00000018781Uncharacterized protein. (136 aa)
MEIOBUncharacterized protein. (344 aa)
ENSPPAP00000018396MPN domain-containing protein. (188 aa)
ENSPPAP00000018389Uncharacterized protein. (112 aa)
HMGN1Uncharacterized protein. (145 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
RFC3Replication factor C subunit 3. (356 aa)
RBX1Ring-box 1. (108 aa)
COPS5COP9 signalosome subunit 5. (333 aa)
AQRRNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. (1485 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (116 aa)
ATAD5ATPase family AAA domain containing 5. (1832 aa)
PRPF19Pre-mRNA processing factor 19. (509 aa)
ENSPPAP00000014117Ubiquitin-like domain-containing protein. (145 aa)
POLD1DNA polymerase. (1133 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
ENSPPAP00000013353Uncharacterized protein. (117 aa)
GTF2H1General transcription factor IIH subunit 1. (548 aa)
COPS2COP9 signalosome subunit 2. (450 aa)
ENSPPAP00000012418Uncharacterized protein. (412 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa)
ELLElongation factor for RNA polymerase II. (621 aa)
CUL4BCullin 4B; Belongs to the cullin family. (932 aa)
COPS8COP9 signalosome subunit 8. (209 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
ENSPPAP00000009924Ubiquitin-like domain-containing protein. (84 aa)
PHF3PHD finger protein 3. (2031 aa)
COPS7BCOP9 signalosome subunit 7B. (278 aa)
POLKDNA polymerase kappa. (897 aa)
COPS4COP9 signalosome subunit 4. (424 aa)
POLR2FRNA polymerase II subunit F. (158 aa)
LOC100990877Ubiquitin-like domain-containing protein. (156 aa)
TCEANCTranscription elongation factor A N-terminal and central domain containing. (351 aa)
COPS7ACOP9 signalosome subunit 7A. (275 aa)
UBCUncharacterized protein. (153 aa)
ZNF830Zinc finger protein 830. (392 aa)
ENSPPAP00000003540Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (246 aa)
SPOCD1TFIIS central domain-containing protein. (639 aa)
TCEA1Transcription elongation factor A1. (304 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1491 aa)
POLR2ERNA polymerase II subunit E. (199 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (2015 aa)
RFC5Replication factor C subunit 5. (354 aa)
TCEA3Transcription elongation factor A3. (348 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
POLR2DRPOL4c domain-containing protein. (110 aa)
USP40Ubiquitin specific peptidase 40; Belongs to the peptidase C19 family. (1246 aa)
UVSSAUV stimulated scaffold protein A. (709 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
POLR2GRNA polymerase II subunit G. (172 aa)
ENSPPAP00000034007Protein kinase domain-containing protein. (324 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (462 aa)
GTF2H3General transcription factor IIH subunit 3. (308 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
POLR2KRNA polymerase II subunit K. (58 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
ENSPPAP00000035310Uncharacterized protein. (121 aa)
ENSPPAP00000035732Uncharacterized protein. (114 aa)
RFC2Replication factor C subunit 2. (320 aa)
BIVMBIVM-ERCC5 readthrough. (1640 aa)
RFC4Replication factor C subunit 4. (363 aa)
TCEANC2Transcription elongation factor A N-terminal and central domain containing 2. (208 aa)
RFC1Replication factor C subunit 1. (1148 aa)
ISY1ISY1 splicing factor homolog. (287 aa)
POLD3Uncharacterized protein. (459 aa)
PPIEPeptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (314 aa)
ENSPPAP00000039593Uncharacterized protein. (103 aa)
COPS6COP9 signalosome subunit 6. (327 aa)
GTF2H5General transcription factor IIH subunit 5. (71 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (146 aa)
KXD1Ubiquitin-like domain-containing protein. (231 aa)
POLR2CRNA polymerase II subunit C. (273 aa)
XAB2XPA binding protein 2. (855 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa)
LIG1DNA ligase. (919 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (556 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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