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POLR2H POLR2H ERCC4 ERCC4 ENSPPAP00000025484 ENSPPAP00000025484 ERCC3 ERCC3 GTF2H2 GTF2H2 USP7 USP7 RPA3 RPA3 UVSSA UVSSA RPA1 RPA1 POLR2G POLR2G ENSPPAP00000034007 ENSPPAP00000034007 GTF2H4 GTF2H4 GTF2H3 GTF2H3 POLR2B POLR2B POLR2K POLR2K XPA XPA ENSPPAP00000035310 ENSPPAP00000035310 ENSPPAP00000035732 ENSPPAP00000035732 RFC2 RFC2 BIVM BIVM RFC4 RFC4 TCEANC2 TCEANC2 RFC1 RFC1 ISY1 ISY1 POLD3 POLD3 PPIE PPIE ENSPPAP00000039593 ENSPPAP00000039593 GTF2H5 GTF2H5 POLE3 POLE3 KXD1 KXD1 POLR2C POLR2C XAB2 XAB2 ERCC1 ERCC1 POLR2A POLR2A RFC5 RFC5 TCEA3 TCEA3 ERCC2 ERCC2 POLR2D POLR2D USP40 USP40 RCBTB2 RCBTB2 POLR2E POLR2E ERCC6 ERCC6 TCEA1 TCEA1 SPOCD1 SPOCD1 ENSPPAP00000003540 ENSPPAP00000003540 ZNF830 ZNF830 UBC UBC TCEANC TCEANC LOC100990877 LOC100990877 POLR2F POLR2F POLK POLK PHF3 PHF3 ENSPPAP00000009924 ENSPPAP00000009924 CDK7 CDK7 CUL4B CUL4B ERCC8 ERCC8 ENSPPAP00000012418 ENSPPAP00000012418 GTF2H1 GTF2H1 ENSPPAP00000013353 ENSPPAP00000013353 POLD2 POLD2 POLD1 POLD1 ENSPPAP00000014117 ENSPPAP00000014117 PRPF19 PRPF19 ATAD5 ATAD5 POLE4 POLE4 AQR AQR RBX1 RBX1 RFC3 RFC3 RCBTB1 RCBTB1 HMGN1 HMGN1 ENSPPAP00000018389 ENSPPAP00000018389 MEIOB MEIOB ENSPPAP00000018781 ENSPPAP00000018781 EP300 EP300 ENSPPAP00000019542 ENSPPAP00000019542 PCNA PCNA POLR2I POLR2I POLE2 POLE2 MNAT1 MNAT1 POLE POLE NRDE2 NRDE2 CUL4A CUL4A RPS27A RPS27A CCNH CCNH DDB1 DDB1 TCEA2 TCEA2 POLD4 POLD4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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POLR2HDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
ENSPPAP00000025484Uncharacterized protein. (77 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa)
GTF2H2General transcription factor IIH subunit. (395 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1109 aa)
RPA3Replication protein A3. (121 aa)
UVSSAUV stimulated scaffold protein A. (709 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
POLR2GRNA polymerase II subunit G. (172 aa)
ENSPPAP00000034007Protein kinase domain-containing protein. (324 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (462 aa)
GTF2H3General transcription factor IIH subunit 3. (308 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
POLR2KRNA polymerase II subunit K. (58 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
ENSPPAP00000035310Uncharacterized protein. (121 aa)
ENSPPAP00000035732Uncharacterized protein. (114 aa)
RFC2Replication factor C subunit 2. (320 aa)
BIVMBIVM-ERCC5 readthrough. (1640 aa)
RFC4Replication factor C subunit 4. (363 aa)
TCEANC2Transcription elongation factor A N-terminal and central domain containing 2. (208 aa)
RFC1Replication factor C subunit 1. (1148 aa)
ISY1ISY1 splicing factor homolog. (287 aa)
POLD3Uncharacterized protein. (459 aa)
PPIEPeptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (314 aa)
ENSPPAP00000039593Uncharacterized protein. (103 aa)
GTF2H5General transcription factor IIH subunit 5. (71 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (146 aa)
KXD1Ubiquitin-like domain-containing protein. (231 aa)
POLR2CRNA polymerase II subunit C. (273 aa)
XAB2XPA binding protein 2. (855 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (2015 aa)
RFC5Replication factor C subunit 5. (354 aa)
TCEA3Transcription elongation factor A3. (348 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
POLR2DRPOL4c domain-containing protein. (110 aa)
USP40Ubiquitin specific peptidase 40; Belongs to the peptidase C19 family. (1246 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (556 aa)
POLR2ERNA polymerase II subunit E. (199 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1491 aa)
TCEA1Transcription elongation factor A1. (304 aa)
SPOCD1TFIIS central domain-containing protein. (639 aa)
ENSPPAP00000003540Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (246 aa)
ZNF830Zinc finger protein 830. (392 aa)
UBCUncharacterized protein. (153 aa)
TCEANCTranscription elongation factor A N-terminal and central domain containing. (351 aa)
LOC100990877Ubiquitin-like domain-containing protein. (156 aa)
POLR2FRNA polymerase II subunit F. (158 aa)
POLKDNA polymerase kappa. (897 aa)
PHF3PHD finger protein 3. (2031 aa)
ENSPPAP00000009924Ubiquitin-like domain-containing protein. (84 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
CUL4BCullin 4B; Belongs to the cullin family. (932 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa)
ENSPPAP00000012418Uncharacterized protein. (412 aa)
GTF2H1General transcription factor IIH subunit 1. (548 aa)
ENSPPAP00000013353Uncharacterized protein. (117 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
POLD1DNA polymerase. (1133 aa)
ENSPPAP00000014117Ubiquitin-like domain-containing protein. (145 aa)
PRPF19Pre-mRNA processing factor 19. (509 aa)
ATAD5ATPase family AAA domain containing 5. (1832 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (116 aa)
AQRRNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. (1485 aa)
RBX1Ring-box 1. (108 aa)
RFC3Replication factor C subunit 3. (356 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
HMGN1Uncharacterized protein. (145 aa)
ENSPPAP00000018389Uncharacterized protein. (112 aa)
MEIOBUncharacterized protein. (344 aa)
ENSPPAP00000018781Uncharacterized protein. (136 aa)
EP300E1A binding protein p300. (2411 aa)
ENSPPAP00000019542Ubiquitin-like domain-containing protein. (136 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa)
NRDE2NRDE-2, necessary for RNA interference, domain containing. (1144 aa)
CUL4ACullin 4A; Belongs to the cullin family. (669 aa)
RPS27ARibosomal protein S27a. (156 aa)
CCNHCyclin H; Belongs to the cyclin family. (325 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
TCEA2Transcription elongation factor A2. (299 aa)
POLD4Uncharacterized protein. (107 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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