STRINGSTRING
STAM2 STAM2 RPS27A RPS27A EPS15 EPS15 SH3KBP1 SH3KBP1 MET MET CBL CBL ENSPPAP00000036655 ENSPPAP00000036655 SH3GL3 SH3GL3 STAM STAM SH3GL2 SH3GL2 LOC100990877 LOC100990877 GRB2 GRB2 LOC100967380 LOC100967380 HGS HGS KXD1 KXD1 SH3GL1 SH3GL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STAM2Signal transducing adaptor molecule 2. (525 aa)
RPS27ARibosomal protein S27a. (156 aa)
EPS15Epidermal growth factor receptor pathway substrate 15. (885 aa)
SH3KBP1SH3 domain containing kinase binding protein 1. (664 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1413 aa)
CBLCbl proto-oncogene. (906 aa)
ENSPPAP00000036655Uncharacterized protein. (389 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (355 aa)
STAMSignal transducing adaptor molecule. (540 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (337 aa)
LOC100990877Ubiquitin-like domain-containing protein. (156 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
LOC100967380BAR domain-containing protein. (385 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
KXD1Ubiquitin-like domain-containing protein. (231 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (368 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.