(18 nodes) HDL assembly network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTCHD4	Patched domain containing 4. (843 aa)
	LOC100983219	A2M domain-containing protein. (1030 aa)
	ENSPPAP00000041755	Uncharacterized protein. (130 aa)
	ZDHHC19	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (273 aa)
	PRKACG	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
	SMPDL3A	Acid sphingomyelinase-like phosphodiesterase. (453 aa)
	PTCHD1	Patched domain containing 1. (888 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
	ZDHHC8	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (751 aa)
	BMP1	Metalloendopeptidase. (986 aa)
	APOA1	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family. (267 aa)
	A2M	Alpha-2-macroglobulin. (1474 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (388 aa)
	PZP	PZP alpha-2-macroglobulin like. (1479 aa)
	A2ML1	Alpha-2-macroglobulin like 1. (1454 aa)
	PLEKHD1	Pleckstrin homology and coiled-coil domain containing D1. (506 aa)
	ABCA1	ATP binding cassette subfamily A member 1. (2264 aa)
	PTCHD3	SSD domain-containing protein. (455 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	APOA1	ENSPPAP00000035173	ENSPPAP00000007656	ATP binding cassette subfamily A member 1.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	0.935
ABCA1	ENSPPAP00000041755	ENSPPAP00000035173	ENSPPAP00000041755	ATP binding cassette subfamily A member 1.	Uncharacterized protein.	0.558
ABCA1	PRKACA	ENSPPAP00000035173	ENSPPAP00000003342	ATP binding cassette subfamily A member 1.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.470
ABCA1	PRKACB	ENSPPAP00000035173	ENSPPAP00000017680	ATP binding cassette subfamily A member 1.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.476
ABCA1	PRKACG	ENSPPAP00000035173	ENSPPAP00000002963	ATP binding cassette subfamily A member 1.	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	0.470
ABCA1	ZDHHC8	ENSPPAP00000035173	ENSPPAP00000003860	ATP binding cassette subfamily A member 1.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.558
APOA1	ABCA1	ENSPPAP00000007656	ENSPPAP00000035173	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	ATP binding cassette subfamily A member 1.	0.935
ENSPPAP00000041755	ABCA1	ENSPPAP00000041755	ENSPPAP00000035173	Uncharacterized protein.	ATP binding cassette subfamily A member 1.	0.558
PRKACA	ABCA1	ENSPPAP00000003342	ENSPPAP00000035173	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	ATP binding cassette subfamily A member 1.	0.470
PRKACA	PRKACB	ENSPPAP00000003342	ENSPPAP00000017680	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.986
PRKACA	PRKACG	ENSPPAP00000003342	ENSPPAP00000002963	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	0.952
PRKACB	ABCA1	ENSPPAP00000017680	ENSPPAP00000035173	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	ATP binding cassette subfamily A member 1.	0.476
PRKACB	PRKACA	ENSPPAP00000017680	ENSPPAP00000003342	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.986
PRKACB	PRKACG	ENSPPAP00000017680	ENSPPAP00000002963	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	0.963
PRKACG	ABCA1	ENSPPAP00000002963	ENSPPAP00000035173	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	ATP binding cassette subfamily A member 1.	0.470
PRKACG	PRKACA	ENSPPAP00000002963	ENSPPAP00000003342	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.952
PRKACG	PRKACB	ENSPPAP00000002963	ENSPPAP00000017680	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.963
ZDHHC8	ABCA1	ENSPPAP00000003860	ENSPPAP00000035173	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	ATP binding cassette subfamily A member 1.	0.558