STRINGSTRING
FLCN FLCN SH3BP4 SH3BP4 ATP6V1B2 ATP6V1B2 LAMTOR5 LAMTOR5 SEC13 SEC13 KIAA1671 KIAA1671 RPTOR RPTOR DMRTC2 DMRTC2 DMRTB1 DMRTB1 ATP6V1A ATP6V1A SESN1 SESN1 GATS GATS PPP1R3A PPP1R3A ATP6V0C ATP6V0C CNST CNST LAMTOR1 LAMTOR1 LIM2 LIM2 FNIP1 FNIP1 ATP6V0D1 ATP6V0D1 DEPDC5 DEPDC5 ENSPPAP00000033799 ENSPPAP00000033799 ATP6V0B ATP6V0B ENSPPAP00000033668 ENSPPAP00000033668 ATP6V1H ATP6V1H NPRL3 NPRL3 LAMTOR4 LAMTOR4 ATP6V1E1 ATP6V1E1 LAMTOR2 LAMTOR2 ATP6V0E1 ATP6V0E1 ENSPPAP00000027450 ENSPPAP00000027450 SESN2 SESN2 ITFG2 ITFG2 MTOR MTOR SZT2 SZT2 CRYBB3 CRYBB3 RRAGB RRAGB ATP6V1D ATP6V1D LAMTOR3 LAMTOR3 RHEBL1 RHEBL1 ATP6V1G3 ATP6V1G3 DMRT2 DMRT2 CASTOR1 CASTOR1 DMRTA2 DMRTA2 MLST8 MLST8 ATP6V1E2 ATP6V1E2 ATP6V0D2 ATP6V0D2 ATP6V1G2 ATP6V1G2 WDR59 WDR59 ATP6V0E2 ATP6V0E2 SLC38A9 SLC38A9 TXNDC11 TXNDC11 LOC100974009 LOC100974009 ENSPPAP00000017113 ENSPPAP00000017113 DMRTA1 DMRTA1 BMT2 BMT2 MACC1 MACC1 ATP6V1C1 ATP6V1C1 WDR24 WDR24 TCIRG1 TCIRG1 RRAGC RRAGC FNIP2 FNIP2 RRAGD RRAGD ENSPPAP00000013091 ENSPPAP00000013091 ATP6V1C2 ATP6V1C2 METTL25 METTL25 DMRT3 DMRT3 ATP6V1F ATP6V1F RHEB RHEB MIOS MIOS ATP6V1B1 ATP6V1B1 CRYGN CRYGN CASTOR2 CASTOR2 LOC100990258 LOC100990258 SEH1L SEH1L ATP6V1G1 ATP6V1G1 NPRL2 NPRL2 RRAGA RRAGA KPTN KPTN C12orf66 C12orf66
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FLCNFolliculin. (579 aa)
SH3BP4SH3 domain binding protein 4. (963 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (525 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (173 aa)
SEC13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (368 aa)
KIAA1671KIAA1671. (1802 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
DMRTC2Uncharacterized protein. (293 aa)
DMRTB1DM domain-containing protein. (289 aa)
ATP6V1AATPase H+ transporting V1 subunit A. (618 aa)
SESN1Sestrin 1. (551 aa)
GATSUncharacterized protein. (164 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1140 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
CNSTConsortin, connexin sorting protein. (725 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
LIM2Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. (215 aa)
FNIP1Folliculin interacting protein 1. (1166 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (392 aa)
DEPDC5DEP domain-containing protein. (1605 aa)
ENSPPAP00000033799Uncharacterized protein. (195 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (261 aa)
ENSPPAP00000033668Uncharacterized protein. (85 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (568 aa)
LAMTOR4Uncharacterized protein. (137 aa)
ATP6V1E1ATPase H+ transporting V1 subunit E1. (226 aa)
LAMTOR2Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (125 aa)
ATP6V0E1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
ENSPPAP00000027450Uncharacterized protein. (77 aa)
SESN2Sestrin 2. (480 aa)
ITFG2Integrin alpha FG-GAP repeat containing 2. (447 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
SZT2SZT2 subunit of KICSTOR complex. (3431 aa)
CRYBB3Crystallin beta B3; Belongs to the beta/gamma-crystallin family. (211 aa)
RRAGBRas related GTP binding B. (374 aa)
ATP6V1DUncharacterized protein. (192 aa)
LAMTOR3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
RHEBL1RHEB like 1. (183 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (124 aa)
DMRT2Doublesex and mab-3 related transcription factor 2. (525 aa)
CASTOR1Cytosolic arginine sensor for mTORC1 subunit 1. (346 aa)
DMRTA2DM domain-containing protein. (503 aa)
MLST8MTOR associated protein, LST8 homolog. (327 aa)
ATP6V1E2ATPase H+ transporting V1 subunit E2. (226 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
WDR59WD repeat domain 59. (974 aa)
ATP6V0E2ATPase H+ transporting V0 subunit e2. (213 aa)
SLC38A9Solute carrier family 38 member 9. (561 aa)
TXNDC11Thioredoxin domain containing 11. (956 aa)
LOC100974009Uncharacterized protein. (184 aa)
ENSPPAP00000017113V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (77 aa)
DMRTA1DMRT like family A1. (486 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
MACC1MET transcriptional regulator MACC1. (852 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
WDR24WD repeat domain 24. (920 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
RRAGCRas related GTP binding C. (399 aa)
FNIP2Folliculin interacting protein 2. (1114 aa)
RRAGDRas related GTP binding D. (400 aa)
ENSPPAP00000013091Uncharacterized protein. (176 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (437 aa)
METTL25Methyltransferase like 25. (603 aa)
DMRT3DMA domain-containing protein. (334 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (147 aa)
RHEBUncharacterized protein. (173 aa)
MIOSMeiosis regulator for oocyte development. (875 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
CRYGNCrystallin gamma N; Belongs to the beta/gamma-crystallin family. (182 aa)
CASTOR2Cytosolic arginine sensor for mTORC1 subunit 2. (267 aa)
LOC100990258V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
SEH1LSEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (360 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
RRAGARas related GTP binding A. (313 aa)
KPTNKaptin, actin binding protein. (436 aa)
C12orf66Chromosome 12 open reading frame 66. (468 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
Server load: low (18%) [HD]