(15 nodes) TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling network (Pan paniscus)

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Your Input:
	KXD1	Ubiquitin-like domain-containing protein. (231 aa)
	RPS27A	Ribosomal protein S27a. (156 aa)
	IRF7	Interferon regulatory factor 7. (516 aa)
	UBE2N	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (148 aa)
	TLR7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
	IRAK4	Interleukin 1 receptor associated kinase 4. (460 aa)
	ENSPPAP00000008828	UBIQUITIN_CONJUGAT_2 domain-containing protein. (133 aa)
	LOC100990877	Ubiquitin-like domain-containing protein. (156 aa)
	ENSPPAP00000004994	TNF receptor-associated factor. (475 aa)
	LOC100986336	TIR domain-containing protein. (1033 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (712 aa)
	LOC100987671	UBIQUITIN_CONJUGAT_2 domain-containing protein. (88 aa)
	ENSPPAP00000040700	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (140 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPPAP00000004994	ENSPPAP00000008828	ENSPPAP00000004994	ENSPPAP00000008828	TNF receptor-associated factor.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.702
ENSPPAP00000004994	ENSPPAP00000040700	ENSPPAP00000004994	ENSPPAP00000040700	TNF receptor-associated factor.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.702
ENSPPAP00000004994	IRAK1	ENSPPAP00000004994	ENSPPAP00000034763	TNF receptor-associated factor.	Interleukin 1 receptor associated kinase 1.	0.911
ENSPPAP00000004994	IRAK4	ENSPPAP00000004994	ENSPPAP00000009286	TNF receptor-associated factor.	Interleukin 1 receptor associated kinase 4.	0.745
ENSPPAP00000004994	IRF7	ENSPPAP00000004994	ENSPPAP00000014100	TNF receptor-associated factor.	Interferon regulatory factor 7.	0.768
ENSPPAP00000004994	KXD1	ENSPPAP00000004994	ENSPPAP00000040077	TNF receptor-associated factor.	Ubiquitin-like domain-containing protein.	0.831
ENSPPAP00000004994	LOC100986336	ENSPPAP00000004994	ENSPPAP00000004282	TNF receptor-associated factor.	TIR domain-containing protein.	0.484
ENSPPAP00000004994	LOC100987671	ENSPPAP00000004994	ENSPPAP00000040277	TNF receptor-associated factor.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.702
ENSPPAP00000004994	LOC100990877	ENSPPAP00000004994	ENSPPAP00000005800	TNF receptor-associated factor.	Ubiquitin-like domain-containing protein.	0.784
ENSPPAP00000004994	MYD88	ENSPPAP00000004994	ENSPPAP00000029064	TNF receptor-associated factor.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.866
ENSPPAP00000004994	RPS27A	ENSPPAP00000004994	ENSPPAP00000023056	TNF receptor-associated factor.	Ribosomal protein S27a.	0.784
ENSPPAP00000004994	TLR7	ENSPPAP00000004994	ENSPPAP00000009572	TNF receptor-associated factor.	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.595
ENSPPAP00000004994	UBE2N	ENSPPAP00000004994	ENSPPAP00000010239	TNF receptor-associated factor.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.702
ENSPPAP00000008828	ENSPPAP00000004994	ENSPPAP00000008828	ENSPPAP00000004994	UBIQUITIN_CONJUGAT_2 domain-containing protein.	TNF receptor-associated factor.	0.702
ENSPPAP00000008828	IRAK1	ENSPPAP00000008828	ENSPPAP00000034763	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Interleukin 1 receptor associated kinase 1.	0.676
ENSPPAP00000008828	IRAK4	ENSPPAP00000008828	ENSPPAP00000009286	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Interleukin 1 receptor associated kinase 4.	0.654
ENSPPAP00000008828	KXD1	ENSPPAP00000008828	ENSPPAP00000040077	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.879
ENSPPAP00000008828	LOC100990877	ENSPPAP00000008828	ENSPPAP00000005800	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.715
ENSPPAP00000008828	RPS27A	ENSPPAP00000008828	ENSPPAP00000023056	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ribosomal protein S27a.	0.715
ENSPPAP00000008828	TRAF6	ENSPPAP00000008828	ENSPPAP00000040651	UBIQUITIN_CONJUGAT_2 domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.949