(30 nodes) (2010) Innate immune natural killer cells and their role in HIV and SIV infection. network (Pan paniscus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

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Predicted Interactions

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Your Input:
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (372 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
	LOC100992309	C-C motif chemokine. (92 aa)
	CCR5	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
	HLA-C	Major histocompatibility complex, class I, C; Belongs to the MHC class I family. (397 aa)
	ZAP70	Tyrosine-protein kinase. (619 aa)
	IL10	Interleukin 10. (178 aa)
	IL7	Interleukin 7. (179 aa)
	CCL20	C-C motif chemokine. (96 aa)
	CCR2	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	CXCR1	C-X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
	IL22	Interleukin 22. (179 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	LOC100987319	Uncharacterized protein. (360 aa)
	GNLY	Granulysin. (173 aa)
	SIGLEC7	Sialic acid binding Ig like lectin 7. (467 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
	IL26	Interleukin 26. (171 aa)
	HLA-G	Major histocompatibility complex, class I, G; Belongs to the MHC class I family. (355 aa)
	WAS	WASP actin nucleation promoting factor. (502 aa)
	CD4	CD4 molecule. (458 aa)
	CD244	CD244 molecule. (367 aa)
	IL6	Uncharacterized protein. (198 aa)
	CD27	CD27 molecule. (260 aa)
	LAT	Linker for activation of T cells. (268 aa)
	SYK	Tyrosine-protein kinase. (635 aa)
	CD34	CD34 molecule. (328 aa)
	CXCR4	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (423 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	CXCR3	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL20	CCR2	ENSPPAP00000002066	ENSPPAP00000002177	C-C motif chemokine.	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.950
CCL20	CCR5	ENSPPAP00000002066	ENSPPAP00000001023	C-C motif chemokine.	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	0.946
CCL20	CCR7	ENSPPAP00000002066	ENSPPAP00000039258	C-C motif chemokine.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.956
CCL20	CD4	ENSPPAP00000002066	ENSPPAP00000023068	C-C motif chemokine.	CD4 molecule.	0.591
CCL20	CXCR1	ENSPPAP00000002066	ENSPPAP00000004941	C-C motif chemokine.	C-X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.873
CCL20	CXCR3	ENSPPAP00000002066	ENSPPAP00000039161	C-C motif chemokine.	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.773
CCL20	CXCR4	ENSPPAP00000002066	ENSPPAP00000037565	C-C motif chemokine.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.915
CCL20	IFNG	ENSPPAP00000002066	ENSPPAP00000038608	C-C motif chemokine.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.636
CCL20	IL10	ENSPPAP00000002066	ENSPPAP00000001878	C-C motif chemokine.	Interleukin 10.	0.602
CCL20	IL15	ENSPPAP00000002066	ENSPPAP00000041805	C-C motif chemokine.	Interleukin; Belongs to the IL-15/IL-21 family.	0.459
CCL20	IL18	ENSPPAP00000002066	ENSPPAP00000009779	C-C motif chemokine.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.503
CCL20	IL2	ENSPPAP00000002066	ENSPPAP00000014571	C-C motif chemokine.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.532
CCL20	IL22	ENSPPAP00000002066	ENSPPAP00000007818	C-C motif chemokine.	Interleukin 22.	0.648
CCL20	IL26	ENSPPAP00000002066	ENSPPAP00000014901	C-C motif chemokine.	Interleukin 26.	0.501
CCL20	IL6	ENSPPAP00000002066	ENSPPAP00000025189	C-C motif chemokine.	Uncharacterized protein.	0.778
CCL20	IL7	ENSPPAP00000002066	ENSPPAP00000001986	C-C motif chemokine.	Interleukin 7.	0.474
CCL20	LOC100992309	ENSPPAP00000002066	ENSPPAP00000000017	C-C motif chemokine.	C-C motif chemokine.	0.442
CCR2	CCL20	ENSPPAP00000002177	ENSPPAP00000002066	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.950
CCR2	CCR5	ENSPPAP00000002177	ENSPPAP00000001023	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family.	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	0.873
CCR2	CCR7	ENSPPAP00000002177	ENSPPAP00000039258	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.793