(20 nodes) (2013) Pyrin- and CARD-only Proteins as Regulators of NLR Functions. network (Pan paniscus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	IL6	Uncharacterized protein. (198 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (953 aa)
	NLRP7	NLR family pyrin domain containing 7. (961 aa)
	MEFV	MEFV innate immuity regulator, pyrin. (784 aa)
	NLRP12	NLR family pyrin domain containing 12. (1005 aa)
	CASP1	Caspase 1; Belongs to the peptidase C14A family. (403 aa)
	NLRP6	NLR family pyrin domain containing 6. (892 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
	CARD17	Caspase recruitment domain family member 17. (110 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (421 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1040 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	CASP1-2	CARD domain-containing protein. (95 aa)
	CASP4	Caspase 4; Belongs to the peptidase C14A family. (321 aa)
	BCL10	CARD domain-containing protein. (316 aa)
	NLRP1	NLR family pyrin domain containing 1. (1471 aa)
	NLRC4	NLR family CARD domain containing 4. (1024 aa)
	AIM2	Absent in melanoma 2. (342 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIM2	BCL10	ENSPPAP00000027408	ENSPPAP00000032949	Absent in melanoma 2.	CARD domain-containing protein.	0.477
AIM2	CARD17	ENSPPAP00000027408	ENSPPAP00000025654	Absent in melanoma 2.	Caspase recruitment domain family member 17.	0.586
AIM2	CASP1	ENSPPAP00000027408	ENSPPAP00000014107	Absent in melanoma 2.	Caspase 1; Belongs to the peptidase C14A family.	0.983
AIM2	CASP1-2	ENSPPAP00000027408	ENSPPAP00000040581	Absent in melanoma 2.	CARD domain-containing protein.	0.609
AIM2	CASP4	ENSPPAP00000027408	ENSPPAP00000039371	Absent in melanoma 2.	Caspase 4; Belongs to the peptidase C14A family.	0.610
AIM2	IL18	ENSPPAP00000027408	ENSPPAP00000009779	Absent in melanoma 2.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.667
AIM2	IL6	ENSPPAP00000027408	ENSPPAP00000025189	Absent in melanoma 2.	Uncharacterized protein.	0.475
AIM2	MEFV	ENSPPAP00000027408	ENSPPAP00000011308	Absent in melanoma 2.	MEFV innate immuity regulator, pyrin.	0.971
AIM2	NLRC4	ENSPPAP00000027408	ENSPPAP00000028964	Absent in melanoma 2.	NLR family CARD domain containing 4.	0.953
AIM2	NLRP1	ENSPPAP00000027408	ENSPPAP00000030933	Absent in melanoma 2.	NLR family pyrin domain containing 1.	0.970
AIM2	NLRP12	ENSPPAP00000027408	ENSPPAP00000011890	Absent in melanoma 2.	NLR family pyrin domain containing 12.	0.860
AIM2	NLRP6	ENSPPAP00000027408	ENSPPAP00000014381	Absent in melanoma 2.	NLR family pyrin domain containing 6.	0.927
AIM2	NLRP7	ENSPPAP00000027408	ENSPPAP00000010743	Absent in melanoma 2.	NLR family pyrin domain containing 7.	0.785
AIM2	NOD1	ENSPPAP00000027408	ENSPPAP00000010664	Absent in melanoma 2.	Nucleotide binding oligomerization domain containing 1.	0.472
AIM2	NOD2	ENSPPAP00000027408	ENSPPAP00000040678	Absent in melanoma 2.	Nucleotide binding oligomerization domain containing 2.	0.560
AIM2	PYCARD	ENSPPAP00000027408	ENSPPAP00000040974	Absent in melanoma 2.	PYD and CARD domain containing.	0.999
APAF1	CARD17	ENSPPAP00000017322	ENSPPAP00000025654	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase recruitment domain family member 17.	0.711
APAF1	CASP1	ENSPPAP00000017322	ENSPPAP00000014107	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 1; Belongs to the peptidase C14A family.	0.834
APAF1	CASP1-2	ENSPPAP00000017322	ENSPPAP00000040581	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	CARD domain-containing protein.	0.735
APAF1	CASP4	ENSPPAP00000017322	ENSPPAP00000039371	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 4; Belongs to the peptidase C14A family.	0.738