STRINGSTRING
PSENEN PSENEN MAPT MAPT PRKACG PRKACG PRKACA PRKACA PLD3 PLD3 GLUD1 GLUD1 CALML5 CALML5 SNCA SNCA CALML3 CALML3 SIRT1 SIRT1 MS4A6A MS4A6A COMT COMT C9orf72 C9orf72 FUS FUS BDNF BDNF PSEN2 PSEN2 CASP3 CASP3 HCRT HCRT ALDH3B1 ALDH3B1 CLU CLU TMEM106B TMEM106B LOC100967430 LOC100967430 CHMP2B CHMP2B PRKACB PRKACB LOC100979570 LOC100979570 DYRK1A DYRK1A NCSTN NCSTN MAOA MAOA CALML4 CALML4 GRN GRN HDAC6 HDAC6 ALDH3A2 ALDH3A2 MAOB MAOB APOE APOE ACHE ACHE AOC1 AOC1 FYN FYN PRL PRL DBH DBH PICALM PICALM CD33 CD33 ASMT ASMT TH TH CALM3 CALM3 HDC HDC PSEN1 PSEN1 ABCA7 ABCA7 CALML6 CALML6 VCP VCP TREM2 TREM2 GSK3B GSK3B CD2AP CD2AP GLUL GLUL AANAT AANAT ALDH3A1 ALDH3A1 BIN1 BIN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
MAPTMicrotubule-associated protein. (776 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
PLD3Phospholipase D family member 3. (490 aa)
GLUD1ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (267 aa)
CALML5Calmodulin like 5. (146 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
SIRT1Sirtuin 1. (693 aa)
MS4A6AMembrane spanning 4-domains A6A. (247 aa)
COMTCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (221 aa)
C9orf72C9orf72-SMCR8 complex subunit. (478 aa)
FUSFUS RNA binding protein. (523 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (329 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (485 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
HCRTOrexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. (131 aa)
ALDH3B1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (468 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa)
TMEM106BTransmembrane protein 106B. (274 aa)
LOC100967430Uncharacterized protein. (291 aa)
CHMP2BCharged multivesicular body protein 2B. (213 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (388 aa)
LOC100979570Glutamine synthetase. (366 aa)
DYRK1ADual specificity tyrosine phosphorylation regulated kinase 1A. (759 aa)
NCSTNNicastrin. (709 aa)
MAOAAmine oxidase. (527 aa)
CALML4Calmodulin like 4. (196 aa)
GRNGranulin precursor. (593 aa)
HDAC6Histone deacetylase 6. (1215 aa)
ALDH3A2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (508 aa)
MAOBAmine oxidase. (520 aa)
APOEApolipoprotein E. (317 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (617 aa)
AOC1Amine oxidase. (755 aa)
FYNTyrosine-protein kinase. (537 aa)
PRLProlactin. (227 aa)
DBHDopamine beta-hydroxylase. (614 aa)
PICALMPhosphatidylinositol binding clathrin assembly protein. (673 aa)
CD33CD33 molecule. (364 aa)
ASMTAcetylserotonin O-methyltransferase. (350 aa)
THTyrosine hydroxylase. (528 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
HDCHistidine decarboxylase. (662 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
ABCA7ATP binding cassette subfamily A member 7. (2146 aa)
CALML6Calmodulin like 6. (181 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
CD2APCD2 associated protein. (650 aa)
GLULGlutamine synthetase. (373 aa)
AANATAralkylamine N-acetyltransferase. (207 aa)
ALDH3A1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (490 aa)
BIN1Bridging integrator 1. (585 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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