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ND6 ND6 CCL5 CCL5 CD44 CD44 DYNC1I1 DYNC1I1 PYCARD PYCARD NOD2 NOD2 CASP1-2 CASP1-2 SLCO3A1 SLCO3A1 SF3A1 SF3A1 CTLA4 CTLA4 INS-IGF2 INS-IGF2 TREM2 TREM2 STAT3 STAT3 PLEKHG1 PLEKHG1 DDX60 DDX60 ABCA1 ABCA1 CALML6 CALML6 NAIP NAIP FCGR1A FCGR1A STAT1 STAT1 VPS52 VPS52 PPARA PPARA LOC100995377 LOC100995377 TRIM5 TRIM5 CD80 CD80 TYROBP TYROBP NCKAP1L NCKAP1L CDKN2A CDKN2A SAMHD1 SAMHD1 CD53 CD53 CXCL10 CXCL10 CSMD1 CSMD1 BECN1 BECN1 HCK HCK GPC6 GPC6 CALM3 CALM3 IL21 IL21 NLRC4 NLRC4 ITGAM ITGAM AIM2 AIM2 MTOR MTOR IRF1 IRF1 GLO1 GLO1 LIPC LIPC SLC8A1 SLC8A1 CD36 CD36 IFNA17 IFNA17 TLR5 TLR5 IFNA5 IFNA5 TTLL7 TTLL7 TBK1 TBK1 IL1RN IL1RN B2M B2M GFER GFER C3AR1 C3AR1 CALML5 CALML5 CALML3 CALML3 TLR2 TLR2 LAG3 LAG3 TLR7 TLR7 IL18 IL18 CNTNAP2 CNTNAP2 C9orf72 C9orf72 NOD1 NOD1 BMP4 BMP4 MEFV MEFV BCR BCR HTT HTT FUS FUS PTEN PTEN CTSB CTSB OAS1 OAS1 PINK1 PINK1 IRF7 IRF7 CASP1 CASP1 ADSS1 ADSS1 BCAS3 BCAS3 HECW1 HECW1 TLR4 TLR4 IRF5 IRF5 CNNM2 CNNM2 PRKCA PRKCA RFC3 RFC3 IFI6 IFI6 PTBP1 PTBP1 CD160 CD160 IFNA21 IFNA21 CALML4 CALML4 IFITM1 IFITM1 CYP17A1 CYP17A1 PPIL1 PPIL1 ADGRE1 ADGRE1 SLC41A1 SLC41A1 LGR5 LGR5 PTPRC PTPRC APOE APOE OAS2 OAS2 CD4 CD4 MYH9 MYH9 CTNNB1 CTNNB1 ADSS2 ADSS2 IL6 IL6 LEP LEP IRF3 IRF3 OASL OASL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ND6NADH-ubiquinone oxidoreductase chain 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (174 aa)
CCL5C-C motif chemokine. (91 aa)
CD44CD44 molecule (Indian blood group). (742 aa)
DYNC1I1Dynein cytoplasmic 1 intermediate chain 1. (628 aa)
PYCARDPYD and CARD domain containing. (195 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
CASP1-2CARD domain-containing protein. (95 aa)
SLCO3A1Solute carrier organic anion transporter family member. (641 aa)
SF3A1Splicing factor 3a subunit 1. (793 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
INS-IGF2INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
PLEKHG1Pleckstrin homology and RhoGEF domain containing G1. (1385 aa)
DDX60Helicase ATP-binding domain-containing protein. (1200 aa)
ABCA1ATP binding cassette subfamily A member 1. (2264 aa)
CALML6Calmodulin like 6. (181 aa)
NAIPNLR family apoptosis inhibitory protein. (1403 aa)
FCGR1AUncharacterized protein. (368 aa)
STAT1Signal transducer and activator of transcription. (759 aa)
VPS52VPS52 subunit of GARP complex. (723 aa)
PPARAPeroxisome proliferator activated receptor alpha. (467 aa)
LOC100995377Uncharacterized protein. (557 aa)
TRIM5Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1- UBE2N (als [...] (493 aa)
CD80CD80 molecule. (288 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (113 aa)
NCKAP1LNCK associated protein 1 like. (1127 aa)
CDKN2AUncharacterized protein. (173 aa)
SAMHD1SAM domain and HD domain-containing protein 1. (626 aa)
CD53Tetraspanin. (219 aa)
CXCL10C-X-C motif chemokine. (96 aa)
CSMD1CUB and Sushi multiple domains 1. (3565 aa)
BECN1Beclin 1. (450 aa)
HCKTyrosine-protein kinase. (526 aa)
GPC6Glypican 6; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (501 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
NLRC4NLR family CARD domain containing 4. (1024 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
AIM2Absent in melanoma 2. (342 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
IRF1Interferon regulatory factor. (325 aa)
GLO1Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (184 aa)
LIPCLipase C, hepatic type. (490 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
IFNA17Interferon alpha 17. (189 aa)
TLR5Toll-like receptor 5; Belongs to the Toll-like receptor family. (858 aa)
IFNA5Interferon alpha 5. (189 aa)
TTLL7Tubulin tyrosine ligase like 7. (887 aa)
TBK1TANK binding kinase 1. (729 aa)
IL1RNInterleukin-1. (180 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
GFERSulfhydryl oxidase. (196 aa)
C3AR1Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family. (482 aa)
CALML5Calmodulin like 5. (146 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
LAG3Lymphocyte activating 3. (527 aa)
TLR7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
CNTNAP2Contactin associated protein like 2. (1331 aa)
C9orf72C9orf72-SMCR8 complex subunit. (478 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
BMP4TGF_BETA_2 domain-containing protein. (402 aa)
MEFVMEFV innate immuity regulator, pyrin. (784 aa)
BCRUncharacterized protein. (1034 aa)
HTTHuntingtin. (3053 aa)
FUSFUS RNA binding protein. (523 aa)
PTENUncharacterized protein. (542 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (339 aa)
OAS12',5'-oligoadenylate synthetase 1. (401 aa)
PINK1PTEN induced kinase 1. (554 aa)
IRF7Interferon regulatory factor 7. (516 aa)
CASP1Caspase 1; Belongs to the peptidase C14A family. (403 aa)
ADSS1Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (499 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (950 aa)
HECW1HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1602 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
IRF5Interferon regulatory factor 5. (515 aa)
CNNM2Cyclin and CBS domain divalent metal cation transport mediator 2. (874 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
RFC3Replication factor C subunit 3. (356 aa)
IFI6Interferon alpha inducible protein 6. (134 aa)
PTBP1Uncharacterized protein. (197 aa)
CD160Uncharacterized protein. (234 aa)
IFNA21Interferon alpha 21. (189 aa)
CALML4Calmodulin like 4. (196 aa)
IFITM1Interferon induced transmembrane protein 1. (125 aa)
CYP17A1Uncharacterized protein; Belongs to the cytochrome P450 family. (350 aa)
PPIL1Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (166 aa)
ADGRE1Adhesion G protein-coupled receptor E1; Belongs to the G-protein coupled receptor 2 family. (886 aa)
SLC41A1Solute carrier family 41 member 1. (513 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1261 aa)
APOEApolipoprotein E. (317 aa)
OAS22'-5'-oligoadenylate synthetase 2. (719 aa)
CD4CD4 molecule. (458 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1964 aa)
CTNNB1Catenin beta 1. (781 aa)
ADSS2Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa)
IL6Uncharacterized protein. (198 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
IRF3Interferon regulatory factor 3. (452 aa)
OASL2'-5'-oligoadenylate synthetase like. (514 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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