STRINGSTRING
SFTPD SFTPD IL5 IL5 IFNG IFNG CCR5 CCR5 A4GALT A4GALT IL10 IL10 VCAM1 VCAM1 INTS10 INTS10 FUT2 FUT2 TBK1 TBK1 TNF TNF SFTPA2 SFTPA2 IL18 IL18 TRAF3 TRAF3 SFTPB SFTPB IRF7 IRF7 IL13 IL13 TLR4 TLR4 TLR3 TLR3 ITK ITK APOBEC3G APOBEC3G APOBEC3G-2 APOBEC3G-2 IL1B IL1B TBX21 TBX21 IRF3 IRF3 VDR VDR IL4 IL4 STAT1 STAT1 SH2D1A SH2D1A MMP9 MMP9 SAMHD1 SAMHD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SFTPDSurfactant protein D. (375 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
A4GALTAlpha 1,4-galactosyltransferase (P blood group). (353 aa)
IL10Interleukin 10. (178 aa)
VCAM1Vascular cell adhesion molecule 1. (715 aa)
INTS10Integrator complex subunit 10. (736 aa)
FUT2L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (343 aa)
TBK1TANK binding kinase 1. (729 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
SFTPA2Surfactant protein A2. (265 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
SFTPBSurfactant protein B. (393 aa)
IRF7Interferon regulatory factor 7. (516 aa)
IL13Interleukin 13. (146 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
ITKTyrosine-protein kinase. (620 aa)
APOBEC3GUncharacterized protein. (101 aa)
APOBEC3G-2DNA dC->dU-editing enzyme APOBEC-3G; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase- dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamin [...] (413 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
TBX21T-box transcription factor 21. (494 aa)
IRF3Interferon regulatory factor 3. (452 aa)
VDRVitamin D receptor. (477 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
STAT1Signal transducer and activator of transcription. (759 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (128 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
SAMHD1SAM domain and HD domain-containing protein 1. (626 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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