STRINGSTRING
IL4 IL4 EGFR EGFR CD36 CD36 IL10 IL10 IL7 IL7 TLR1 TLR1 IFIT1 IFIT1 ISG15 ISG15 NF1 NF1 CD226 CD226 CD86 CD86 CD4 CD4 IL6 IL6 CD80 CD80 CD40 CD40 STAT1 STAT1 STAT3 STAT3 GZMB GZMB CD83 CD83 TIGIT TIGIT CSF1 CSF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
IL10Interleukin 10. (178 aa)
IL7Interleukin 7. (179 aa)
TLR1Toll-like receptor. (786 aa)
IFIT1Interferon induced protein with tetratricopeptide repeats 1. (476 aa)
ISG15ISG15 ubiquitin like modifier. (165 aa)
NF1Neurofibromin 1. (2839 aa)
CD226CD226 molecule. (336 aa)
CD86CD86 molecule. (329 aa)
CD4CD4 molecule. (458 aa)
IL6Uncharacterized protein. (198 aa)
CD80CD80 molecule. (288 aa)
CD40CD40 molecule. (277 aa)
STAT1Signal transducer and activator of transcription. (759 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (281 aa)
CD83CD83 molecule. (205 aa)
TIGITT cell immunoreceptor with Ig and ITIM domains. (290 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (549 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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