STRINGSTRING
IRF3 IRF3 CCR5 CCR5 ELOC ELOC CPSF6 CPSF6 DDX55 DDX55 SIGLEC1 SIGLEC1 MCM2 MCM2 SLX1A SLX1A APOB APOB LOC100986336 LOC100986336 TLR1 TLR1 TLR7 TLR7 DDX31 DDX31 DCAF1 DCAF1 MAVS MAVS PLK1 PLK1 MUS81 MUS81 ELOB ELOB IL18 IL18 UBE2N UBE2N CUL4B CUL4B CGAS CGAS NCK1 NCK1 NUP153 NUP153 IFI16 IFI16 CASP1 CASP1 IL2 IL2 LOC100994688 LOC100994688 TLR3 TLR3 DDX18 DDX18 SERINC3 SERINC3 CUL4A CUL4A MX1 MX1 CUL5 CUL5 CD4 CD4 DDX10 DDX10 ERCC4 ERCC4 CARD17 CARD17 AIM2 AIM2 MYD88 MYD88 SYK SYK NCK2 NCK2 LOC100987164 LOC100987164 SAMHD1 SAMHD1 SUN2 SUN2 PQBP1 PQBP1 SLFN11 SLFN11 TRIM5 TRIM5 TLR8 TLR8 CDK1 CDK1 IL1B IL1B ATG5 ATG5 PPIA PPIA SOCS2 SOCS2 UBE2W UBE2W CXCR4 CXCR4 CASP1-2 CASP1-2 EME1 EME1 TRIM21 TRIM21 UBE2V2 UBE2V2 SLX4 SLX4 ERCC1 ERCC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IRF3Interferon regulatory factor 3. (452 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
ELOCSkp1_POZ domain-containing protein; Belongs to the SKP1 family. (112 aa)
CPSF6Cleavage and polyadenylation specific factor 6. (566 aa)
DDX55RNA helicase. (600 aa)
SIGLEC1Sialic acid binding Ig like lectin 1. (1709 aa)
MCM2DNA helicase; Belongs to the MCM family. (904 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa)
APOBApolipoprotein B. (4535 aa)
LOC100986336TIR domain-containing protein. (1033 aa)
TLR1Toll-like receptor. (786 aa)
TLR7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
DDX31RNA helicase. (851 aa)
DCAF1DDB1 and CUL4 associated factor 1. (1507 aa)
MAVSMitochondrial antiviral signaling protein. (540 aa)
PLK1Serine/threonine-protein kinase PLK. (603 aa)
MUS81MUS81 structure-specific endonuclease subunit. (551 aa)
ELOBUncharacterized protein. (104 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
UBE2NUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (148 aa)
CUL4BCullin 4B; Belongs to the cullin family. (932 aa)
CGASCyclic GMP-AMP synthase. (509 aa)
NCK1Cytoplasmic protein. (377 aa)
NUP153Nucleoporin 153. (1506 aa)
IFI16Interferon gamma inducible protein 16. (733 aa)
CASP1Caspase 1; Belongs to the peptidase C14A family. (403 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
LOC100994688Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (115 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
DDX18RNA helicase. (670 aa)
SERINC3Serine incorporator 3. (466 aa)
CUL4ACullin 4A; Belongs to the cullin family. (669 aa)
MX1Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (662 aa)
CUL5Cullin 5; Belongs to the cullin family. (775 aa)
CD4CD4 molecule. (458 aa)
DDX10RNA helicase. (876 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
CARD17Caspase recruitment domain family member 17. (110 aa)
AIM2Absent in melanoma 2. (342 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
SYKTyrosine-protein kinase. (635 aa)
NCK2Cytoplasmic protein. (380 aa)
LOC100987164Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (112 aa)
SAMHD1SAM domain and HD domain-containing protein 1. (626 aa)
SUN2Sad1 and UNC84 domain containing 2. (717 aa)
PQBP1Polyglutamine binding protein 1. (265 aa)
SLFN11Schlafen family member 11. (888 aa)
TRIM5Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1- UBE2N (als [...] (493 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1041 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
PPIAPeptidyl-prolyl cis-trans isomerase A, N-terminally processed; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding; Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. (165 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
UBE2WUBIQUITIN_CONJUGAT_2 domain-containing protein. (191 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (423 aa)
CASP1-2CARD domain-containing protein. (95 aa)
EME1Essential meiotic structure-specific endonuclease 1. (571 aa)
TRIM21Tripartite motif containing 21. (475 aa)
UBE2V2UBIQUITIN_CONJUGAT_2 domain-containing protein. (151 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1833 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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