STRINGSTRING
MAPK8 MAPK8 TNF TNF SNCA SNCA MAP2K4 MAP2K4 RPS6KB1 RPS6KB1 HTT HTT PRKCG PRKCG PINK1 PINK1 DYRK1A DYRK1A MARK2 MARK2 FGFR3 FGFR3 EIF2AK2 EIF2AK2 YWHAB YWHAB GSK3A GSK3A LRRK1 LRRK1 MCL1 MCL1 CDK1 CDK1 ROS1 ROS1 LRRK2 LRRK2 MAP3K14 MAP3K14 GSK3B GSK3B CDKL1 CDKL1 MAPK14 MAPK14 MAPK10 MAPK10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK8Mitogen-activated protein kinase. (427 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (371 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
HTTHuntingtin. (3053 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PINK1PTEN induced kinase 1. (554 aa)
DYRK1ADual specificity tyrosine phosphorylation regulated kinase 1A. (759 aa)
MARK2Non-specific serine/threonine protein kinase. (788 aa)
FGFR3Fibroblast growth factor receptor. (780 aa)
EIF2AK2Eukaryotic translation initiation factor 2-alpha kinase 2. (552 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (463 aa)
LRRK1Leucine rich repeat kinase 1. (2015 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
ROS1Tyrosine-protein kinase receptor. (2347 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
CDKL1Cyclin dependent kinase like 1; Belongs to the protein kinase superfamily. (358 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.