STRINGSTRING
RAD23A RAD23A UNG UNG MUS81 MUS81 FEN1 FEN1 MYC MYC RNASEH2B RNASEH2B DCAF1 DCAF1 CCNO CCNO RNASEH2A RNASEH2A CUL4B CUL4B CGAS CGAS RAD50 RAD50 IL2 IL2 HLTF HLTF MLH1 MLH1 TDG TDG TUB TUB CCNF CCNF PCNA PCNA SMUG1 SMUG1 TET2 TET2 MSH3 MSH3 ESCO1 ESCO1 MSH2 MSH2 CUL4A CUL4A CUL5 CUL5 CD4 CD4 CD28 CD28 DDB1 DDB1 EME2 EME2 ERCC4 ERCC4 DNA2 DNA2 ESCO2 ESCO2 XRCC1 XRCC1 EXO1 EXO1 FEN1-2 FEN1-2 ERCC1 ERCC1 TOP1 TOP1 EME1 EME1 LMNB1 LMNB1 XPA XPA BIVM BIVM DDA1 DDA1 RAD23B RAD23B ENDOG ENDOG MSH6 MSH6 RNASEH2C RNASEH2C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAD23ARAD23 homolog A, nucleotide excision repair protein. (363 aa)
UNGUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (313 aa)
MUS81MUS81 structure-specific endonuclease subunit. (551 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
RNASEH2BRibonuclease H2 subunit B. (303 aa)
DCAF1DDB1 and CUL4 associated factor 1. (1507 aa)
CCNOCyclin O; Belongs to the cyclin family. (350 aa)
RNASEH2ARibonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (299 aa)
CUL4BCullin 4B; Belongs to the cullin family. (932 aa)
CGASCyclic GMP-AMP synthase. (509 aa)
RAD50Zinc-hook domain-containing protein. (1312 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
HLTFHelicase like transcription factor. (1013 aa)
MLH1MutL homolog 1. (756 aa)
TDGThymine DNA glycosylase. (410 aa)
TUBTubby-like protein; Belongs to the TUB family. (561 aa)
CCNFCyclin F; Belongs to the cyclin family. (772 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
SMUG1Single-strand-selective monofunctional uracil-DNA glycosylase 1. (270 aa)
TET2Tet methylcytosine dioxygenase 2. (2023 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1113 aa)
ESCO1Uncharacterized protein. (386 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
CUL4ACullin 4A; Belongs to the cullin family. (669 aa)
CUL5Cullin 5; Belongs to the cullin family. (775 aa)
CD4CD4 molecule. (458 aa)
CD28CD28 molecule. (220 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (378 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
DNA2DNA replication helicase/nuclease 2. (1060 aa)
ESCO2Establishment of sister chromatid cohesion N-acetyltransferase 2. (600 aa)
XRCC1X-ray repair cross complementing 1. (556 aa)
EXO1Exonuclease 1. (846 aa)
FEN1-2Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (308 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (765 aa)
EME1Essential meiotic structure-specific endonuclease 1. (571 aa)
LMNB1Lamin B1; Belongs to the intermediate filament family. (586 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
BIVMBIVM-ERCC5 readthrough. (1640 aa)
DDA1DET1 and DDB1 associated 1. (102 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (409 aa)
ENDOGEndonuclease. (188 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1304 aa)
RNASEH2CUncharacterized protein. (247 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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