(39 nodes) (2018) T-Cell Exhaustion in Chronic Infections: Reversing the State of Exhaustion and Reinvigorating Optimal Protective Immune Responses. network (Pan paniscus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RARA	Uncharacterized protein. (609 aa)
	TIGIT	T cell immunoreceptor with Ig and ITIM domains. (290 aa)
	HDAC9	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1058 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	HDAC7	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1011 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (223 aa)
	IRF4	Interferon regulatory factor 4. (392 aa)
	SRC	Tyrosine-protein kinase. (458 aa)
	KLRG1	Killer cell lectin like receptor G1. (195 aa)
	CD40	CD40 molecule. (277 aa)
	FOXP1	Forkhead box P1. (676 aa)
	BATF	Basic leucine zipper ATF-like transcription factor. (125 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
	CD244	CD244 molecule. (367 aa)
	CD4	CD4 molecule. (458 aa)
	EOMES	Eomesodermin. (680 aa)
	LOC100971924-3	Histone H3. (136 aa)
	LOC100971924-2	Histone H3. (136 aa)
	CD160	Uncharacterized protein. (234 aa)
	HDAC5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1108 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1248 aa)
	NFATC1	Nuclear factor of activated T cells 1. (975 aa)
	FOXO1	Fork-head domain-containing protein. (527 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
	IRF7	Interferon regulatory factor 7. (516 aa)
	FOXP3	Forkhead box P3. (441 aa)
	IL22	Interleukin 22. (179 aa)
	LAG3	Lymphocyte activating 3. (527 aa)
	SKP2	S-phase kinase associated protein 2. (437 aa)
	LOC100971924	Histone H3; Belongs to the histone H3 family. (136 aa)
	H3-4	Histone cluster 3 H3. (136 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	IRF9	Interferon regulatory factor 9. (392 aa)
	IL7	Interleukin 7. (179 aa)
	IL10	Interleukin 10. (178 aa)
	ZAP70	Tyrosine-protein kinase. (619 aa)
	H3-3A	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC100985978	Histone H3; Belongs to the histone H3 family. (136 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BATF	CD4	ENSPPAP00000030966	ENSPPAP00000023068	Basic leucine zipper ATF-like transcription factor.	CD4 molecule.	0.571
BATF	CTLA4	ENSPPAP00000030966	ENSPPAP00000037872	Basic leucine zipper ATF-like transcription factor.	Cytotoxic T-lymphocyte associated protein 4.	0.420
BATF	EOMES	ENSPPAP00000030966	ENSPPAP00000022091	Basic leucine zipper ATF-like transcription factor.	Eomesodermin.	0.544
BATF	FOXO1	ENSPPAP00000030966	ENSPPAP00000015231	Basic leucine zipper ATF-like transcription factor.	Fork-head domain-containing protein.	0.473
BATF	FOXP3	ENSPPAP00000030966	ENSPPAP00000009817	Basic leucine zipper ATF-like transcription factor.	Forkhead box P3.	0.503
BATF	IFNG	ENSPPAP00000030966	ENSPPAP00000038608	Basic leucine zipper ATF-like transcription factor.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.452
BATF	IL2	ENSPPAP00000030966	ENSPPAP00000014571	Basic leucine zipper ATF-like transcription factor.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.423
BATF	IL22	ENSPPAP00000030966	ENSPPAP00000007818	Basic leucine zipper ATF-like transcription factor.	Interleukin 22.	0.515
BATF	IRF4	ENSPPAP00000030966	ENSPPAP00000036456	Basic leucine zipper ATF-like transcription factor.	Interferon regulatory factor 4.	0.898
BATF	LAG3	ENSPPAP00000030966	ENSPPAP00000007418	Basic leucine zipper ATF-like transcription factor.	Lymphocyte activating 3.	0.445
BATF	NFATC1	ENSPPAP00000030966	ENSPPAP00000015289	Basic leucine zipper ATF-like transcription factor.	Nuclear factor of activated T cells 1.	0.452
BATF	SKP2	ENSPPAP00000030966	ENSPPAP00000007297	Basic leucine zipper ATF-like transcription factor.	S-phase kinase associated protein 2.	0.437
CD160	CD244	ENSPPAP00000018808	ENSPPAP00000024463	Uncharacterized protein.	CD244 molecule.	0.746
CD160	CD4	ENSPPAP00000018808	ENSPPAP00000023068	Uncharacterized protein.	CD4 molecule.	0.674
CD160	CTLA4	ENSPPAP00000018808	ENSPPAP00000037872	Uncharacterized protein.	Cytotoxic T-lymphocyte associated protein 4.	0.671
CD160	EOMES	ENSPPAP00000018808	ENSPPAP00000022091	Uncharacterized protein.	Eomesodermin.	0.558
CD160	IFNG	ENSPPAP00000018808	ENSPPAP00000038608	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.550
CD160	IL10	ENSPPAP00000018808	ENSPPAP00000001878	Uncharacterized protein.	Interleukin 10.	0.407
CD160	IL2	ENSPPAP00000018808	ENSPPAP00000014571	Uncharacterized protein.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.468
CD160	IL21	ENSPPAP00000018808	ENSPPAP00000029076	Uncharacterized protein.	Interleukin; Belongs to the IL-15/IL-21 family.	0.449