STRINGSTRING
ICAM2 ICAM2 CALR CALR ZAP70 ZAP70 JAK1 JAK1 HBZ HBZ CALML5 CALML5 CALML3 CALML3 IL2 IL2 LCK LCK PLCG1 PLCG1 CALML4 CALML4 CANX CANX ICAM1 ICAM1 CD4 CD4 FYN FYN LAT LAT CALM3 CALM3 CALML6 CALML6 SRC SRC GZMB GZMB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ICAM2Intercellular adhesion molecule 2. (275 aa)
CALRCalreticulin. (417 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
HBZHemoglobin subunit zeta; Belongs to the globin family. (142 aa)
CALML5Calmodulin like 5. (146 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
LCKTyrosine-protein kinase. (524 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1248 aa)
CALML4Calmodulin like 4. (196 aa)
CANXCalnexin. (592 aa)
ICAM1Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (537 aa)
CD4CD4 molecule. (458 aa)
FYNTyrosine-protein kinase. (537 aa)
LATLinker for activation of T cells. (268 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
CALML6Calmodulin like 6. (181 aa)
SRCTyrosine-protein kinase. (458 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (281 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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