STRINGSTRING
CALML5 CALML5 TLR1 TLR1 TBK1 TBK1 TLR10 TLR10 IL5 IL5 TRAF6 TRAF6 ALB ALB CTLA4 CTLA4 STAT3 STAT3 CALML6 CALML6 STAT1 STAT1 CD69 CD69 CD34 CD34 IRAK2 IRAK2 CALM3 CALM3 MYD88 MYD88 KRT16 KRT16 IRF1 IRF1 IRF7 IRF7 TAB2 TAB2 TAB3 TAB3 CXCL1 CXCL1 IL13 IL13 TLR4 TLR4 TLR3 TLR3 IRF5 IRF5 BCL2 BCL2 CCL2 CCL2 CALML4 CALML4 CD86 CD86 CD4 CD4 IRF3 IRF3 IL6 IL6 TLR5 TLR5 IL10 IL10 TIRAP TIRAP IL17A IL17A TRAF3 TRAF3 IRAK4 IRAK4 TAB1 TAB1 IL4 IL4 TLR2 TLR2 CALML3 CALML3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CALML5Calmodulin like 5. (146 aa)
TLR1Toll-like receptor. (786 aa)
TBK1TANK binding kinase 1. (729 aa)
TLR10TIR domain-containing protein; Belongs to the Toll-like receptor family. (811 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
ALBAlbumin. (609 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
CALML6Calmodulin like 6. (181 aa)
STAT1Signal transducer and activator of transcription. (759 aa)
CD69CD69 molecule. (199 aa)
CD34CD34 molecule. (328 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (625 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
KRT16Keratin 16; Belongs to the intermediate filament family. (485 aa)
IRF1Interferon regulatory factor. (325 aa)
IRF7Interferon regulatory factor 7. (516 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa)
CXCL1C-X-C motif chemokine. (107 aa)
IL13Interleukin 13. (146 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
IRF5Interferon regulatory factor 5. (515 aa)
BCL2BCL2 apoptosis regulator. (193 aa)
CCL2C-C motif chemokine. (99 aa)
CALML4Calmodulin like 4. (196 aa)
CD86CD86 molecule. (329 aa)
CD4CD4 molecule. (458 aa)
IRF3Interferon regulatory factor 3. (452 aa)
IL6Uncharacterized protein. (198 aa)
TLR5Toll-like receptor 5; Belongs to the Toll-like receptor family. (858 aa)
IL10Interleukin 10. (178 aa)
TIRAPTIR domain-containing protein. (226 aa)
IL17AInterleukin 17A. (155 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (508 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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