STRINGSTRING
NOD2 NOD2 IFNG IFNG TLR8 TLR8 IL6 IL6 IDO2 IDO2 CD4 CD4 ARG1 ARG1 IL10 IL10 IDO1 IDO1 TLR7 TLR7 TLR2 TLR2 LOC100986336 LOC100986336
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1041 aa)
IL6Uncharacterized protein. (198 aa)
IDO2Indoleamine 2,3-dioxygenase 2. (376 aa)
CD4CD4 molecule. (458 aa)
ARG1Arginase. (322 aa)
IL10Interleukin 10. (178 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (403 aa)
TLR7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
LOC100986336TIR domain-containing protein. (1033 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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