STRINGSTRING
H3-4 H3-4 LOC100985978 LOC100985978 NUMB NUMB LOC100971924 LOC100971924 ZHX2 ZHX2 WNT1 WNT1 TLR2 TLR2 SKP2 SKP2 IL22 IL22 MSL2 MSL2 IL4 IL4 TLR7 TLR7 IL18 IL18 CUL4B CUL4B VDAC3 VDAC3 CUL4A CUL4A PRKCD PRKCD LOC100971924-3 LOC100971924-3 LOC100971924-2 LOC100971924-2 RHOC RHOC HDAC1 HDAC1 BCL2 BCL2 PRKACB PRKACB SP1 SP1 ATF5 ATF5 FOXO4 FOXO4 PAX8 PAX8 TLR3 TLR3 IL17A IL17A P4HA2 P4HA2 PPARG PPARG EGR1 EGR1 IRF7 IRF7 IL2 IL2 WDR5 WDR5 FOXO1 FOXO1 TNFRSF10B TNFRSF10B EGFR EGFR IL34 IL34 FOXM1 FOXM1 HOXA13 HOXA13 LAMTOR5 LAMTOR5 TRAF6 TRAF6 BNIP3 BNIP3 CDA CDA IFNG IFNG DNMT3L DNMT3L CSF1R CSF1R NFYA NFYA SETDB1 SETDB1 PDCD4 PDCD4 TNFSF10 TNFSF10 STAT3 STAT3 ROCK1 ROCK1 TLR8 TLR8 AR AR MMP9 MMP9 CREBBP CREBBP BECN1 BECN1 DNMT3A DNMT3A MYD88 MYD88 BNIP3L BNIP3L AIM2 AIM2 MVP MVP MTOR MTOR IRF3 IRF3 IL6 IL6 LOX LOX DDB1 DDB1 PRMT1 PRMT1 CD4 CD4 H3-3A H3-3A IL10 IL10 SMC5 SMC5 PRKACG PRKACG PRKACA PRKACA CEBPA CEBPA TBK1 TBK1 TNF TNF LOC100986336 LOC100986336
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H3-4Histone cluster 3 H3. (136 aa)
LOC100985978Histone H3; Belongs to the histone H3 family. (136 aa)
NUMBNUMB endocytic adaptor protein. (651 aa)
LOC100971924Histone H3; Belongs to the histone H3 family. (136 aa)
ZHX2Zinc fingers and homeoboxes 2. (837 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
SKP2S-phase kinase associated protein 2. (437 aa)
IL22Interleukin 22. (179 aa)
MSL2MSL complex subunit 2. (577 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
TLR7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
CUL4BCullin 4B; Belongs to the cullin family. (932 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
CUL4ACullin 4A; Belongs to the cullin family. (669 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
LOC100971924-3Histone H3. (136 aa)
LOC100971924-2Histone H3. (136 aa)
RHOCRas homolog family member C. (193 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
BCL2BCL2 apoptosis regulator. (193 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (388 aa)
SP1Sp1 transcription factor. (786 aa)
ATF5Activating transcription factor 5. (281 aa)
FOXO4Forkhead box O4. (505 aa)
PAX8Paired box 8. (456 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
IL17AInterleukin 17A. (155 aa)
P4HA2Prolyl 4-hydroxylase subunit alpha 2. (535 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
IRF7Interferon regulatory factor 7. (516 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
WDR5WD repeat domain 5. (334 aa)
FOXO1Fork-head domain-containing protein. (527 aa)
TNFRSF10BTNF receptor superfamily member 10b. (439 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
IL34Interleukin 34. (242 aa)
FOXM1Forkhead box M1. (763 aa)
HOXA13Homeobox domain-containing protein. (209 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (173 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
BNIP3BCL2 interacting protein 3. (252 aa)
CDACytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
DNMT3LPHD-type domain-containing protein. (387 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
NFYANuclear transcription factor Y subunit alpha. (347 aa)
SETDB1SET domain bifurcated histone lysine methyltransferase 1. (1292 aa)
PDCD4Programmed cell death 4. (469 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (281 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1041 aa)
ARAndrogen receptor. (882 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
CREBBPCREB binding protein. (2414 aa)
BECN1Beclin 1. (450 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
BNIP3LBCL2 interacting protein 3 like. (219 aa)
AIM2Absent in melanoma 2. (342 aa)
MVPMajor vault protein. (853 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
IRF3Interferon regulatory factor 3. (452 aa)
IL6Uncharacterized protein. (198 aa)
LOXLysyl oxidase. (417 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
CD4CD4 molecule. (458 aa)
H3-3AHistone H3; Belongs to the histone H3 family. (136 aa)
IL10Interleukin 10. (178 aa)
SMC5SMC_N domain-containing protein. (1101 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
CEBPABZIP domain-containing protein. (141 aa)
TBK1TANK binding kinase 1. (729 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC100986336TIR domain-containing protein. (1033 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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