STRINGSTRING
YTHDC1 YTHDC1 LOC100985978 LOC100985978 H3-3A H3-3A UBE2A UBE2A RAD21 RAD21 MAPT MAPT ENSPPAP00000003540 ENSPPAP00000003540 HNRNPA1 HNRNPA1 H3-4 H3-4 LOC100971924 LOC100971924 MUS81 MUS81 E2F1 E2F1 MAVS MAVS PNLDC1 PNLDC1 FANCD2 FANCD2 DPPA2 DPPA2 G3BP1 G3BP1 ATM ATM DUSP1 DUSP1 UBR2 UBR2 GTSF1 GTSF1 KPNB1 KPNB1 DUSP6 DUSP6 TDRKH TDRKH MOV10L1 MOV10L1 RNASEL RNASEL RAD50 RAD50 MBD2 MBD2 DPPA4 DPPA4 SUV39H2 SUV39H2 BRCA1 BRCA1 MOV10 MOV10 PIWIL4 PIWIL4 SIN3A SIN3A NR2F2 NR2F2 EZH2 EZH2 PRMT5 PRMT5 LOC100971924-2 LOC100971924-2 LOC100971924-3 LOC100971924-3 PCNA PCNA PIWIL2 PIWIL2 EXD1 EXD1 MECP2 MECP2 SIRT6 SIRT6 RUNX3 RUNX3 PARP2 PARP2 SIRT7 SIRT7 ERCC4 ERCC4 RAD18 RAD18 KDM4B KDM4B TASOR TASOR UHRF1 UHRF1 EPRS1 EPRS1 TET1 TET1 XRCC6 XRCC6 DROSHA DROSHA TUT4 TUT4 BECN1 BECN1 SAMHD1 SAMHD1 RUVBL2 RUVBL2 TUT7 TUT7 TARDBP TARDBP TEX15 TEX15 DGCR8 DGCR8 RUVBL1 RUVBL1 XPA XPA SETDB1 SETDB1 TIA1 TIA1 FKBP6 FKBP6 ALKBH1 ALKBH1 TDRD1 TDRD1 DNMT3L DNMT3L DCLRE1C DCLRE1C TDRD12 TDRD12 TNPO1 TNPO1 GLIS3 GLIS3 CTCF CTCF SLX4 SLX4 ERCC1 ERCC1 GADD45B GADD45B UPF1 UPF1 KPNA2 KPNA2 ZCCHC8 ZCCHC8
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
YTHDC1YTH domain containing 1. (735 aa)
LOC100985978Histone H3; Belongs to the histone H3 family. (136 aa)
H3-3AHistone H3; Belongs to the histone H3 family. (136 aa)
UBE2AUbiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
RAD21RAD21 cohesin complex component. (631 aa)
MAPTMicrotubule-associated protein. (776 aa)
ENSPPAP00000003540Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (246 aa)
HNRNPA1Heterogeneous nuclear ribonucleoprotein A1. (372 aa)
H3-4Histone cluster 3 H3. (136 aa)
LOC100971924Histone H3; Belongs to the histone H3 family. (136 aa)
MUS81MUS81 structure-specific endonuclease subunit. (551 aa)
E2F1E2F transcription factor 1. (397 aa)
MAVSMitochondrial antiviral signaling protein. (540 aa)
PNLDC1PARN like, ribonuclease domain containing 1. (531 aa)
FANCD2FA complementation group D2. (1259 aa)
DPPA2Developmental pluripotency associated 2. (298 aa)
G3BP1G3BP stress granule assembly factor 1. (466 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
UBR2E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa)
GTSF1Gametocyte specific factor 1. (175 aa)
KPNB1Karyopherin subunit beta 1. (876 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
TDRKHTudor and KH domain containing. (605 aa)
MOV10L1Mov10 like RISC complex RNA helicase 1. (1211 aa)
RNASELRibonuclease L. (741 aa)
RAD50Zinc-hook domain-containing protein. (1312 aa)
MBD2MBD domain-containing protein. (365 aa)
DPPA4Developmental pluripotency associated 4. (303 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (410 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1849 aa)
MOV10Mov10 RISC complex RNA helicase. (1005 aa)
PIWIL4Piwi like RNA-mediated gene silencing 4; Belongs to the argonaute family. (852 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
NR2F2Uncharacterized protein. (333 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
PRMT5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (620 aa)
LOC100971924-2Histone H3. (136 aa)
LOC100971924-3Histone H3. (136 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
PIWIL2Uncharacterized protein; Belongs to the argonaute family. (974 aa)
EXD1Exonuclease 3'-5' domain containing 1. (572 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (493 aa)
SIRT6Sirtuin 6. (355 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
PARP2Poly [ADP-ribose] polymerase. (565 aa)
SIRT7Sirtuin 7. (353 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
RAD18RAD18 E3 ubiquitin protein ligase. (495 aa)
KDM4BLysine demethylase 4B. (1130 aa)
TASORTranscription activation suppressor. (1486 aa)
UHRF1Ubiquitin like with PHD and ring finger domains 1. (805 aa)
EPRS1Glutamyl-prolyl-tRNA synthetase. (1519 aa)
TET1Tet methylcytosine dioxygenase 1. (2134 aa)
XRCC6X-ray repair cross complementing 6. (547 aa)
DROSHADrosha ribonuclease III. (1369 aa)
TUT4Terminal uridylyl transferase 4. (1659 aa)
BECN1Beclin 1. (450 aa)
SAMHD1SAM domain and HD domain-containing protein 1. (626 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
TUT7Terminal uridylyl transferase 7. (1540 aa)
TARDBPTAR DNA binding protein. (414 aa)
TEX15Testis expressed 15, meiosis and synapsis associated. (3176 aa)
DGCR8DGCR8 microprocessor complex subunit. (773 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
SETDB1SET domain bifurcated histone lysine methyltransferase 1. (1292 aa)
TIA1TIA1 cytotoxic granule associated RNA binding protein. (386 aa)
FKBP6Peptidylprolyl isomerase. (327 aa)
ALKBH1AlkB homolog 1, histone H2A dioxygenase. (389 aa)
TDRD1Tudor domain containing 1. (1189 aa)
DNMT3LPHD-type domain-containing protein. (387 aa)
DCLRE1CDNA cross-link repair 1C. (590 aa)
TDRD12Uncharacterized protein. (1151 aa)
TNPO1Transportin 1. (898 aa)
GLIS3GLIS family zinc finger 3. (930 aa)
CTCFCCCTC-binding factor. (727 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1833 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
UPF1UPF1 RNA helicase and ATPase. (1096 aa)
KPNA2Importin subunit alpha; Functions in nuclear protein import. (529 aa)
ZCCHC8CCHC-type domain-containing protein. (707 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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