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ATP8 ATP8 ATP6 ATP6 ITIH2 ITIH2 CLDN2 CLDN2 SLC9A3R1 SLC9A3R1 VWF VWF UBR1 UBR1 MEN1 MEN1 CTSB CTSB ADAMTS13 ADAMTS13 CDH23 CDH23 NKX2-5 NKX2-5 CTRB1 CTRB1 MYO9B MYO9B CTRC CTRC CEL CEL VHL VHL CASR CASR RHBDD2 RHBDD2 CTRB2 CTRB2 PRSS1 PRSS1 CPA1 CPA1 CDKN2A CDKN2A AARS1 AARS1 CFTR CFTR APOA5 APOA5 APOC2 APOC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATP8ATP synthase protein 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (68 aa)
ATP6ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (226 aa)
ITIH2Inter-alpha-trypsin inhibitor heavy chain 2. (946 aa)
CLDN2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (358 aa)
VWFVon Willebrand factor. (2813 aa)
UBR1E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1743 aa)
MEN1Menin 1. (615 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (339 aa)
ADAMTS13ADAM metallopeptidase with thrombospondin type 1 motif 13. (1397 aa)
CDH23Cadherin related 23. (3359 aa)
NKX2-5NK2 homeobox 5. (325 aa)
CTRB1Chymotrypsinogen B1; Belongs to the peptidase S1 family. (263 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2129 aa)
CTRCChymotrypsin C; Belongs to the peptidase S1 family. (268 aa)
CELCarboxyl ester lipase. (660 aa)
VHLVon Hippel-Lindau tumor suppressor. (213 aa)
CASRCalcium sensing receptor. (1078 aa)
RHBDD2Rhomboid domain containing 2. (364 aa)
CTRB2Chymotrypsinogen B2; Belongs to the peptidase S1 family. (263 aa)
PRSS1Serine protease 1; Belongs to the peptidase S1 family. (261 aa)
CPA1Carboxypeptidase A1. (420 aa)
CDKN2AUncharacterized protein. (173 aa)
AARS1Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1480 aa)
APOA5Apolipoprotein A5. (366 aa)
APOC2Uncharacterized protein. (178 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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