(40 nodes) (2022) Analysis of the Whole-Genome Sequences from an Equus Parent-Offspring Trio Provides Insight into the Genomic Incompatibilities in the Hybrid Mule. network (Pan paniscus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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experimentally determined

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gene neighborhood

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Your Input:
	ICAM1	Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (537 aa)
	PMS2	PMS1 homolog 2, mismatch repair system component. (771 aa)
	UGT2B4	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
	PARP4	Poly [ADP-ribose] polymerase. (1724 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	BCR	Uncharacterized protein. (1034 aa)
	PTEN	Uncharacterized protein. (542 aa)
	POLD2	DNA polymerase delta 2, accessory subunit. (504 aa)
	DAAM1	Dishevelled associated activator of morphogenesis 1. (1078 aa)
	ENSPPAP00000017468	Uncharacterized protein. (336 aa)
	UGT2A3	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (527 aa)
	LDHB	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
	PDE10A	Phosphodiesterase. (856 aa)
	CD4	CD4 molecule. (458 aa)
	CDC25A	Cell division cycle 25A. (524 aa)
	PRIM1	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa)
	UGT2B11	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
	ERCC4	ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	LOC100980327	Uncharacterized protein. (437 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
	LOC100976704	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	LOC100995377	Uncharacterized protein. (557 aa)
	UGT2B15	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
	PDE5A	Phosphodiesterase. (875 aa)
	IL4R	Interleukin 4 receptor. (873 aa)
	PDE4D	Phosphodiesterase. (706 aa)
	PDE3A	Phosphodiesterase. (1141 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	MLLT10	MLLT10 histone lysine methyltransferase DOT1L cofactor. (1016 aa)
	PLA2G4A	Phospholipase A2. (749 aa)
	CCNB1	Cyclin B1; Belongs to the cyclin family. (433 aa)
	UGT1A3	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (534 aa)
	EGFR	Receptor protein-tyrosine kinase. (1201 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	CCNB1	ENSPPAP00000009058	ENSPPAP00000042346	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin B1; Belongs to the cyclin family.	0.595
ATM	CD4	ENSPPAP00000009058	ENSPPAP00000023068	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	CD4 molecule.	0.401
ATM	CDC25A	ENSPPAP00000009058	ENSPPAP00000023128	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cell division cycle 25A.	0.685
ATM	EGFR	ENSPPAP00000009058	ENSPPAP00000043172	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Receptor protein-tyrosine kinase.	0.515
ATM	ERCC4	ENSPPAP00000009058	ENSPPAP00000025260	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ERCC excision repair 4, endonuclease catalytic subunit.	0.720
ATM	HRAS	ENSPPAP00000009058	ENSPPAP00000010823	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	HRas proto-oncogene, GTPase.	0.483
ATM	KRAS	ENSPPAP00000009058	ENSPPAP00000030946	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	KRAS proto-oncogene, GTPase.	0.561
ATM	LOC100995377	ENSPPAP00000009058	ENSPPAP00000033339	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.583
ATM	MSH2	ENSPPAP00000009058	ENSPPAP00000022004	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.935
ATM	MTOR	ENSPPAP00000009058	ENSPPAP00000026600	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.566
ATM	MYC	ENSPPAP00000009058	ENSPPAP00000007219	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity).	0.681
ATM	PMS2	ENSPPAP00000009058	ENSPPAP00000003534	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	PMS1 homolog 2, mismatch repair system component.	0.784
ATM	POLD2	ENSPPAP00000009058	ENSPPAP00000013565	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA polymerase delta 2, accessory subunit.	0.423
ATM	PTEN	ENSPPAP00000009058	ENSPPAP00000012238	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.583
BCR	DAAM1	ENSPPAP00000011493	ENSPPAP00000014880	Uncharacterized protein.	Dishevelled associated activator of morphogenesis 1.	0.438
BCR	GRB2	ENSPPAP00000011493	ENSPPAP00000009849	Uncharacterized protein.	Growth factor receptor bound protein 2.	0.992
CCNB1	ATM	ENSPPAP00000042346	ENSPPAP00000009058	Cyclin B1; Belongs to the cyclin family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.595
CCNB1	CDC25A	ENSPPAP00000042346	ENSPPAP00000023128	Cyclin B1; Belongs to the cyclin family.	Cell division cycle 25A.	0.856
CCNB1	EGFR	ENSPPAP00000042346	ENSPPAP00000043172	Cyclin B1; Belongs to the cyclin family.	Receptor protein-tyrosine kinase.	0.561
CCNB1	LOC100995377	ENSPPAP00000042346	ENSPPAP00000033339	Cyclin B1; Belongs to the cyclin family.	Uncharacterized protein.	0.425