(29 nodes) Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SHC3	SHC adaptor protein 3. (501 aa)
	MAPK8IP2	Mitogen-activated protein kinase 8 interacting protein 2. (692 aa)
	SHC1	SHC adaptor protein 1. (584 aa)
	DAB1	DAB adaptor protein 1. (588 aa)
	APBA2	Amyloid beta precursor protein binding family A member 2. (751 aa)
	RGS12	Regulator of G protein signaling 12. (1446 aa)
	TNS2	Tensin 2. (1419 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	RABGAP1L	RAB GTPase activating protein 1 like. (815 aa)
	TNS1	Tensin 1. (1740 aa)
	NOS1AP	Nitric oxide synthase 1 adaptor protein. (506 aa)
	SHC4	SHC adaptor protein 4. (630 aa)
	TBC1D4	TBC1 domain family member 4. (1176 aa)
	SHC2	Uncharacterized protein. (539 aa)
	GULP1	GULP PTB domain containing engulfment adaptor 1. (304 aa)
	APBA3	Amyloid beta precursor protein binding family A member 3. (575 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1. (295 aa)
	MAPK8IP1	Mitogen-activated protein kinase 8 interacting protein 1. (713 aa)
	ANKS1A	Ankyrin repeat and sterile alpha motif domain containing 1A. (1130 aa)
	NUMB	NUMB endocytic adaptor protein. (651 aa)
	RABGAP1	RAB GTPase activating protein 1. (1062 aa)
	TNS3	Tensin 3. (1445 aa)
	NUMBL	NUMB like endocytic adaptor protein. (613 aa)
	APBB1	Amyloid beta precursor protein binding family B member 1. (772 aa)
	APBA1	Amyloid beta precursor protein binding family A member 1. (791 aa)
	APBB2	Amyloid beta precursor protein binding family B member 2. (738 aa)
	TBC1D1	TBC1 domain family member 1. (1168 aa)
	EPS8	Epidermal growth factor receptor pathway substrate 8. (822 aa)
	APBB3	Amyloid beta precursor protein binding family B member 3. (493 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APBA1	APBB1	ENSPPAP00000028551	ENSPPAP00000025296	Amyloid beta precursor protein binding family A member 1.	Amyloid beta precursor protein binding family B member 1.	0.635
APBA1	APBB2	ENSPPAP00000028551	ENSPPAP00000029073	Amyloid beta precursor protein binding family A member 1.	Amyloid beta precursor protein binding family B member 2.	0.625
APBA2	APBB1	ENSPPAP00000017525	ENSPPAP00000025296	Amyloid beta precursor protein binding family A member 2.	Amyloid beta precursor protein binding family B member 1.	0.587
APBA2	APBB2	ENSPPAP00000017525	ENSPPAP00000029073	Amyloid beta precursor protein binding family A member 2.	Amyloid beta precursor protein binding family B member 2.	0.656
APBB1	APBA1	ENSPPAP00000025296	ENSPPAP00000028551	Amyloid beta precursor protein binding family B member 1.	Amyloid beta precursor protein binding family A member 1.	0.635
APBB1	APBA2	ENSPPAP00000025296	ENSPPAP00000017525	Amyloid beta precursor protein binding family B member 1.	Amyloid beta precursor protein binding family A member 2.	0.587
APBB1	APBB2	ENSPPAP00000025296	ENSPPAP00000029073	Amyloid beta precursor protein binding family B member 1.	Amyloid beta precursor protein binding family B member 2.	0.792
APBB1	DAB1	ENSPPAP00000025296	ENSPPAP00000017402	Amyloid beta precursor protein binding family B member 1.	DAB adaptor protein 1.	0.423
APBB1	MAPK8IP1	ENSPPAP00000025296	ENSPPAP00000002400	Amyloid beta precursor protein binding family B member 1.	Mitogen-activated protein kinase 8 interacting protein 1.	0.559
APBB2	APBA1	ENSPPAP00000029073	ENSPPAP00000028551	Amyloid beta precursor protein binding family B member 2.	Amyloid beta precursor protein binding family A member 1.	0.625
APBB2	APBA2	ENSPPAP00000029073	ENSPPAP00000017525	Amyloid beta precursor protein binding family B member 2.	Amyloid beta precursor protein binding family A member 2.	0.656
APBB2	APBB1	ENSPPAP00000029073	ENSPPAP00000025296	Amyloid beta precursor protein binding family B member 2.	Amyloid beta precursor protein binding family B member 1.	0.792
DAB1	APBB1	ENSPPAP00000017402	ENSPPAP00000025296	DAB adaptor protein 1.	Amyloid beta precursor protein binding family B member 1.	0.423
MAPK8IP1	APBB1	ENSPPAP00000002400	ENSPPAP00000025296	Mitogen-activated protein kinase 8 interacting protein 1.	Amyloid beta precursor protein binding family B member 1.	0.559
MAPK8IP1	MAPK8IP2	ENSPPAP00000002400	ENSPPAP00000013154	Mitogen-activated protein kinase 8 interacting protein 1.	Mitogen-activated protein kinase 8 interacting protein 2.	0.988
MAPK8IP2	MAPK8IP1	ENSPPAP00000013154	ENSPPAP00000002400	Mitogen-activated protein kinase 8 interacting protein 2.	Mitogen-activated protein kinase 8 interacting protein 1.	0.988
NUMB	NUMBL	ENSPPAP00000005566	ENSPPAP00000024968	NUMB endocytic adaptor protein.	NUMB like endocytic adaptor protein.	0.446
NUMBL	NUMB	ENSPPAP00000024968	ENSPPAP00000005566	NUMB like endocytic adaptor protein.	NUMB endocytic adaptor protein.	0.446
TBC1D1	TBC1D4	ENSPPAP00000029219	ENSPPAP00000038590	TBC1 domain family member 1.	TBC1 domain family member 4.	0.505
TBC1D4	TBC1D1	ENSPPAP00000038590	ENSPPAP00000029219	TBC1 domain family member 4.	TBC1 domain family member 1.	0.505