STRINGSTRING
GNL2 GNL2 WDR75 WDR75 MDN1 MDN1 IMP3 IMP3 RAN-2 RAN-2 XRN1 XRN1 GAR1 GAR1 POP7 POP7 ENSPPAP00000003688 ENSPPAP00000003688 RIOK1 RIOK1 POP1 POP1 GNL3 GNL3 NXT1 NXT1 LOC100986453 LOC100986453 RPP25L RPP25L WDR36 WDR36 RPP40 RPP40 DKC1 DKC1 SNU13 SNU13 LOC100968762 LOC100968762 RIOK2 RIOK2 NOP56 NOP56 BMS1 BMS1 UTP4 UTP4 NHP2 NHP2 IMP4 IMP4 WDR3 WDR3 LSG1 LSG1 XPO1 XPO1 NXT2 NXT2 NVL NVL NXF3 NXF3 EIF6 EIF6 UTP15 UTP15 MPHOSPH10 MPHOSPH10 CSNK2A3 CSNK2A3 EMG1 EMG1 XRN2 XRN2 UTP18 UTP18 GNL3L GNL3L NOP10 NOP10 REXO5 REXO5 ENSPPAP00000025066 ENSPPAP00000025066 REXO1 REXO1 ENSPPAP00000025320 ENSPPAP00000025320 NAT10 NAT10 HEATR1 HEATR1 NOP58 NOP58 PWP2 PWP2 RCL1 RCL1 UTP6 UTP6 EFL1 EFL1 CSNK2A2 CSNK2A2 UTP14C UTP14C REXO2 REXO2 NOB1 NOB1 POP4 POP4 NOL6 NOL6 NXF1 NXF1 RPP38 RPP38 RBM28 RBM28 TBL3 TBL3 WDR43 WDR43 GTPBP4 GTPBP4 FCF1 FCF1 UTP14A UTP14A AK6 AK6 SPATA5 SPATA5 POP5 POP5 RPP30 RPP30 NMD3 NMD3 SBDS SBDS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNL2Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (794 aa)
WDR75WD repeat domain 75. (830 aa)
MDN1Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (5596 aa)
IMP3IMP U3 small nucleolar ribonucleoprotein 3. (184 aa)
RAN-2GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (217 aa)
XRN15'-3' exoribonuclease 1. (1706 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (218 aa)
POP7Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences; Belongs to the histone-like Alba family. (140 aa)
ENSPPAP00000003688Uncharacterized protein. (258 aa)
RIOK1Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (532 aa)
POP1POP1 homolog, ribonuclease P/MRP subunit. (1023 aa)
GNL3G protein nucleolar 3. (549 aa)
NXT1Nuclear transport factor 2 like export factor 1. (140 aa)
LOC100986453RRP7 domain-containing protein. (276 aa)
RPP25LRibonuclease P/MRP subunit p25 like. (163 aa)
WDR36WD repeat domain 36. (895 aa)
RPP40Ribonuclease P/MRP subunit p40. (363 aa)
DKC1Dyskerin pseudouridine synthase 1. (514 aa)
SNU13Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (132 aa)
LOC100968762Tr-type G domain-containing protein. (484 aa)
RIOK2RIO kinase 2. (540 aa)
NOP56NOP56 ribonucleoprotein. (594 aa)
BMS1BMS1 ribosome biogenesis factor. (1260 aa)
UTP4UTP4 small subunit processome component. (686 aa)
NHP2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa)
IMP4IMP U3 small nucleolar ribonucleoprotein 4. (291 aa)
WDR3WD repeat domain 3. (943 aa)
LSG1Large 60S subunit nuclear export GTPase 1. (658 aa)
XPO1Exportin 1. (1071 aa)
NXT2Nuclear transport factor 2 like export factor 2. (197 aa)
NVLNuclear VCP like. (848 aa)
NXF3Nuclear RNA export factor 3. (531 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
UTP15UTP15 small subunit processome component. (503 aa)
MPHOSPH10U3 small nucleolar ribonucleoprotein protein MPP10; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing; Belongs to the MPP10 family. (681 aa)
CSNK2A3Casein kinase 2 alpha 1; Belongs to the protein kinase superfamily. (391 aa)
EMG1EMG1 N1-specific pseudouridine methyltransferase. (244 aa)
XRN25'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (950 aa)
UTP18UTP18 small subunit processome component. (554 aa)
GNL3LG protein nucleolar 3 like. (582 aa)
NOP10NOP10 ribonucleoprotein. (64 aa)
REXO5RNA exonuclease 5. (774 aa)
ENSPPAP00000025066Uncharacterized protein. (183 aa)
REXO1RNA exonuclease 1 homolog. (1207 aa)
ENSPPAP00000025320NTF2 domain-containing protein. (406 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1034 aa)
HEATR1HEAT repeat containing 1. (2144 aa)
NOP58NOP58 ribonucleoprotein. (539 aa)
PWP2Uncharacterized protein. (919 aa)
RCL1RNA terminal phosphate cyclase like 1. (373 aa)
UTP6UTP6 small subunit processome component. (597 aa)
EFL1Elongation factor like GTPase 1. (1091 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (323 aa)
UTP14CUTP14C small subunit processome component. (774 aa)
REXO2RNA exonuclease 2. (237 aa)
NOB1RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (412 aa)
POP4Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. (220 aa)
NOL6Nucleolar protein 6. (1155 aa)
NXF1Nuclear RNA export factor 1. (619 aa)
RPP38Ribonuclease P/MRP subunit p38. (311 aa)
RBM28RNA binding motif protein 28. (761 aa)
TBL3Transducin beta like 3. (808 aa)
WDR43WD repeat domain 43. (601 aa)
GTPBP4Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (634 aa)
FCF1FCF1 rRNA-processing protein. (200 aa)
UTP14AUTP14A small subunit processome component. (771 aa)
AK6Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (172 aa)
SPATA5Spermatogenesis associated 5. (744 aa)
POP5Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (163 aa)
RPP30Ribonuclease P/MRP subunit p30. (318 aa)
NMD360S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (529 aa)
SBDSUncharacterized protein. (250 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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