STRINGSTRING
PMS2 PMS2 RPA2 RPA2 POLD2 POLD2 POLD1 POLD1 MLH1 MLH1 RFC3 RFC3 PCNA PCNA MSH3 MSH3 MSH2 MSH2 SSBP1 SSBP1 POLD4 POLD4 RPA3 RPA3 EXO1 EXO1 RPA1 RPA1 RFC2 RFC2 RFC4 RFC4 MSH6 MSH6 RFC1 RFC1 POLD3 POLD3 MLH3 MLH3 LIG1 LIG1 RFC5 RFC5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PMS2PMS1 homolog 2, mismatch repair system component. (771 aa)
RPA2Replication protein A2. (270 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
POLD1DNA polymerase. (1133 aa)
MLH1MutL homolog 1. (756 aa)
RFC3Replication factor C subunit 3. (356 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1113 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
SSBP1Single stranded DNA binding protein 1. (148 aa)
POLD4Uncharacterized protein. (107 aa)
RPA3Replication protein A3. (121 aa)
EXO1Exonuclease 1. (846 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
RFC2Replication factor C subunit 2. (320 aa)
RFC4Replication factor C subunit 4. (363 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1304 aa)
RFC1Replication factor C subunit 1. (1148 aa)
POLD3Uncharacterized protein. (459 aa)
MLH3MutL homolog 3. (1450 aa)
LIG1DNA ligase. (919 aa)
RFC5Replication factor C subunit 5. (354 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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