STRINGSTRING
BAD BAD EGF EGF MAPK8 MAPK8 RPS6KB2 RPS6KB2 PIK3R3 PIK3R3 ARAF ARAF CRKL CRKL PAK5 PAK5 MAPK1 MAPK1 MYC MYC SOS1 SOS1 MAP2K4 MAP2K4 GRB2 GRB2 PIK3R2 PIK3R2 PIK3CA PIK3CA RPS6KB1 RPS6KB1 SHC3 SHC3 MAP2K1 MAP2K1 AKT2 AKT2 HRAS HRAS NCK1 NCK1 MAP2K2 MAP2K2 NRG1 NRG1 CDKN1B CDKN1B CRK CRK SHC1 SHC1 PRKCA PRKCA PIK3CB PIK3CB CBLB CBLB BTC BTC NRG4 NRG4 NRG3 NRG3 PRKCB PRKCB NRG2 NRG2 RAF1 RAF1 ERBB3 ERBB3 AKT3 AKT3 PAK2 PAK2 BRAF BRAF ABL1 ABL1 MTOR MTOR EIF4EBP1 EIF4EBP1 PAK4 PAK4 CDKN1A CDKN1A NCK2 NCK2 NRAS NRAS MAPK9 MAPK9 CBL CBL MAP2K7 MAP2K7 GAB1 GAB1 HBEGF HBEGF PLCG2 PLCG2 STAT5B STAT5B AKT1 AKT1 SOS2 SOS2 SRC SRC GSK3B GSK3B ERBB2 ERBB2 ERBB4 ERBB4 SHC4 SHC4 PIK3R1 PIK3R1 STAT5A STAT5A CAMK2A CAMK2A AREG AREG EREG EREG MAPK10 MAPK10 TGFA TGFA ELK1 ELK1 SHC2 SHC2 PAK6 PAK6 ABL2 ABL2 EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BADBCL2 associated agonist of cell death. (168 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (371 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
SHC3SHC adaptor protein 3. (501 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
NCK1Cytoplasmic protein. (377 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (392 aa)
NRG1Neuregulin 1. (645 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
SHC1SHC adaptor protein 1. (584 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
CBLBCbl proto-oncogene B. (982 aa)
BTCBetacellulin. (178 aa)
NRG4Neuregulin 4. (117 aa)
NRG3Neuregulin 3. (719 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
NRG2Uncharacterized protein. (705 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1344 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (766 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
PAK4P21 (RAC1) activated kinase 4. (590 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
NCK2Cytoplasmic protein. (380 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CBLCbl proto-oncogene. (906 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (408 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
STAT5BSignal transducer and activator of transcription. (789 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1325 aa)
SRCTyrosine-protein kinase. (458 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
ERBB4Receptor protein-tyrosine kinase. (1386 aa)
SHC4SHC adaptor protein 4. (630 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
AREGEGF-like domain-containing protein. (274 aa)
EREGEpiregulin. (169 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
TGFATransforming growth factor alpha. (181 aa)
ELK1ETS transcription factor ELK1. (428 aa)
SHC2Uncharacterized protein. (539 aa)
PAK6Non-specific serine/threonine protein kinase. (680 aa)
ABL2Tyrosine-protein kinase. (1131 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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